Adbanced therapy for liver fibrosis and cirrhosis by adipose derived mesenchymal stem cell
Project/Area Number |
23659847
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Emergency medicine
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
AKAHOSHI Tomohiko 九州大学, 大学院医学研究院, 講師 (20336019)
富川 盛雅 九州大学, 大学病院, その他 (60325454)
村田 正治 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744)
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Co-Investigator(Renkei-kenkyūsha) |
MURATA Masaharu 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744)
TOMIKAWA Morimasa 九州大学, 病院先端医工学診療部, 准教授 (60325454)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 肝硬変 / 脂肪由来幹細胞 / HGF / 脂肪由来間葉系幹細胞 / 肝臓線維化 / 門脈圧亢進症 |
Research Abstract |
Liverfibrosis was introduced into rats by repeated carbon tetrachloride intraperitoneal injections. After 6 weeks ccl4 injection, rats received splenectomy operation, PKH26 labelled ADSCs were transplanted into hepatic cirrhosis rats through the caudal vein. PKH26 staining indicated migrated ADSCs existing at liver fibrotic area, with strong expression of hepatocyte growth factor (HGF) shown by anti-HGF antibodies. Three days after ADSCs transplantation, liver function and fibrosis had ameliorated, as compared to rats treated with CCl4 alone.Conclusions: This findings indicates ADSCs transplantation is a valuable method for the therapy of hepatic fibrosis.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation2013
Author(s)
Nagao Y, Akahoshi T, Uehara H, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y
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Journal Title
Related Report
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[Journal Article] Treatment of Bleeding Rectal Varices With Transumbilical Venous Obliteration of the Inferior Mesenteric Vein.2013
Author(s)
Hashimoto N, Akahoshi T, Kamori M, Tomikawa M, Yoshida D, Nagao Y, Morita K, Kayashima H, Ikegami T, Yoshizumi T, Taketomi A, Shirabe K, Maehara Y
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Journal Title
Surg Laparosc Endosc Percutan Tech.
Volume: Jun;23(3)
Related Report
Peer Reviewed
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[Journal Article] Kindlin-1 expression is involved in migration and invasion in pancreatic cancer.2013
Author(s)
Mahawithitwong P, Ohuchida K, Ikenaga N, Fujita H, Zhao M, Kozono S, Shindo K, Ohtsuka T, Aishima S, Mizumoto K, Tanaka M
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Journal Title
International Journal of Oncology.
Volume: Apr;42(4)
Pages: 1360-6
Related Report
Peer Reviewed
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[Journal Article] Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma.2013
Author(s)
Mahawithitwong P, Ohuchida K, Ikenaga N, Fujita H, Zhao M, Kozono S, Shindo K, Ohtsuka T, Aishima S, Mizumoto K, Tanaka M
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Journal Title
Pancreas.
Volume: May;42(4)
Pages: 663-9
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Peer Reviewed
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[Journal Article] Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak : AComparative Study Using Electrosurgical and Stapling Devices in Swine.2013
Author(s)
Tetsuo IKEDA, Tomohiko AKAHOSHI, Hirofumi KAWANAKA, Hideaki UCHIYAMA, Yo-ichi YAMASHITA, Masaru MORITA, Eiji OKI, Hiroshi SAEKI, Koshi SUGIMACHI, Toru IKEGAMI, Tomoharu Yoshizumi, Yuji Soejima, Ken SHIRABE, Koshi MIMORI, Masayuki WATANABE, Makoto HASHIZUME and Yoshihiko MAEHARA
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Journal Title
Fukuoka Acta Med
Volume: 104(12)
Pages: 507-514
Related Report
Peer Reviewed
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[Journal Article] Evaluation of a Transection Method for Distal Pancreatectomy : A Comparative Study on the Use of Electrosurgical and Stapling Devices in Swine.2013
Author(s)
Tetsuo IKEDA, Tomohiko AKAHOSHI, Hirofumi KAWANAKA, Hideaki UCHIYAMA, Yo-ichi YAMASHITA, Masaru MORITA, Eiji OKI, Hiroshi SAEKI, Koshi SUGIMACHI, Toru IKEGAMI, Tomoharu Yoshizumi, Yuji Soejima, Ken SHIRABE, Koshi MIMORI, Masayuki WATANABE, Makoto HASHIZUME and Yoshihiko MAEHARA
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Journal Title
Fukuoka Acta Med
Volume: 104(12)
Pages: 515-522
NAID
Related Report
Peer Reviewed
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[Journal Article] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation.2013
Author(s)
Nagao Y, Akahoshi T, Uehara H, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y.
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Journal Title
Surg Today
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Quality of life after laparoscopy-assisted pylorus-preserving gastrectomy : an evaluation using a questionnaire mailed to the patients2012
Author(s)
Tomikawa M, Korenaga D, Akahoshi T,Kohshi K, Sugimachi K, Nagao Y, Tsutsumi N, Takenaka K, Kakeji Y, Hashizume M, Maehara Y
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Journal Title
Surg Today
Volume: 42(7)
Pages: 625-32
NAID
Related Report
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[Journal Article] Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients.2012
Author(s)
Kinjo N, Nagao Y, Akahoshi T, Masahiro K, Hashimoto N, Uehara H, Kawanaka H, Tomikawa M, Shirabe K, Hashizume M, Maehara Y.
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Journal Title
Hepatol Res.
Volume: in press
Issue: 9
Pages: 933-941
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype.2012
Author(s)
Motomura T, Shirabe K, Furusyo N, Yoshizumi T, Ikegami T, Soejima Y, Akahoshi T, Tomikawa M, Fukuhara T, Hayashi J, Maehara Y.
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Journal Title
BMC Gastroenterol.
Volume: 2012 Nov 12;12:158
Issue: 1
DOI
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Peer Reviewed
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[Journal Article] Liver regeneration is promoted by increasing serotonin content in rat liver with secondary biliary cirrhosis2011
Author(s)
Nagao Y, Akahoshi T(Corresponding author), Kamori M, Uehara H, Hashimoto N, Kinjo N, Shirabe K, Taketomi A, Tomikawa M, Hashizume M, Maehara Y
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Journal Title
Hepatol Res
Volume: 41(8) (Epub)
Pages: 784-94
NAID
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[Presentation] 腹腔鏡下脾臓定期出術における合併症予防の工夫.2013
Author(s)
堤 敬文, 山口翔平, 富川盛雅, 赤星朋比古, 杉山雅彦, 太田光彦, 木村和恵, 坂口善久, 楠本哲也, 橋爪 誠, 前原喜彦, 池尻公二
Organizer
第20回日本門脈圧亢進症学会総会
Place of Presentation
名古屋
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