The effect of IL-18 and gender difference on inflammation-related insulin resistance.

• Project/Area Number: 23659852
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: KOTANI Joji 兵庫医科大学, 医学部, 教授 (80360270)
• Co-Investigator(Renkei-kenkyūsha): USAMI Makoto 神戸大学, 保健学研究科, 教授 (00193855) ; AOYAMA Michiko 神戸大学, 保健学研究科, 保健学研究員 (40566121) ; OKIMURA Yasuhiko 神戸女子大学, 家政学部, 教授 (30204100)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 集中治療医学 / IL-18 / 敗血症 / エンドトキシン / インスリン / 血糖値 / 性差

Research Abstract

The purpose of this study was to evaluate the effects of endogenous IL-18 and its gender difference on inflammation-related insulin resistance. The endogenous IL-18 might inhibit hyperglycemia and hyperinsulinemia during acute inflammation. The plasma insulin concentration was higher in male than in female mice, however, the relation of IL-18 to this gender differencve has not been elucidated clearly yet. Further studies are needed to investigate the role ofendogenous IL-18 on the gender difference in inflammation-related insulin resistance.

Research Products

• [Journal Article] 血糖管理による生体反応の制御はどこまで可能か (2013)
  • Author(s): 石川(青山)倫子、小谷穣治
  • Journal Title: 侵襲と免疫 Volume: 22巻 Pages: 48-50
• [Journal Article] 血糖管理による生体反応の制御はどこまで可能か？ (2013)
  • Author(s): 石川（青山） 倫子, 小谷 穣治
  • Journal Title: 侵襲と免疫 Volume: 22巻
• [Presentation] IL-18 supresed hyperglycemia in hyperacute phase of endotoxemia (2013)
  • Author(s): Hayato Yamashita, Michiko Aoyama-Ishikawa, Taketo Inoue, Makoto Miyoshi, Noriaki Maeshige, Yasuhiko Okimura, Makoto Usami, Joji Kotani.
  • Organizer: The 35 th Congress of the European Society of Parenteral and Enteral Nutrition.
  • Place of Presentation: Germany
  • Year and Date: 2013-09-14
• [Presentation] マウス急性エンドトキシン血症下の高血糖へ及ぼすIL-18の関与の検討 (2013)
  • Author(s): 山下勇人、青山倫子、高原美樹、山内千里、岡伸樹、井上岳人、前重伯壮、三好真琴、置村康彦、宇佐美眞、小谷穣治
  • Organizer: 第28回日本Shock学会
  • Place of Presentation: 東京
• [Presentation] 急性炎症下における血糖変動へのIL-18の関与 (2012)
  • Author(s): 山下勇人,青山倫子,高原美樹,山内千里,置村康彦,宇佐美眞,小谷穣治
  • Organizer: 第19回外科侵襲とサイトカイン研究会
  • Place of Presentation: 神戸
  • Year and Date: 2012-01-28
• [Presentation] エンドトキシン血症下の血糖変動とインスリンシグナルへのIL-18の役割 (2012)
  • Author(s): 青山倫子,高原美樹,山内千里,宇佐美眞,小谷穣治
  • Organizer: 第27回日本Shock学会
  • Place of Presentation: 東京
• [Presentation] Gender differences in neutrophil apoptosis, blood corticosterone, insulin and glucose levels (2011)
  • Author(s): Chisato Yamauchi, Michiko Aoyama, MikiTakahara, Noriaki Maeshige, Makoto Miyoshi, Yasuhiko Okimura, Joji Kotani, Makoto Usami.
  • Organizer: The 33th Congress of the European Society of Parenteral and Enteral Nutrition.
  • Place of Presentation: Sweden, Goteborgs