| Project/Area Number |
23659852
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
KOTANI Joji 兵庫医科大学, 医学部, 教授 (80360270)
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| Co-Investigator(Renkei-kenkyūsha) |
USAMI Makoto 神戸大学, 保健学研究科, 教授 (00193855)
AOYAMA Michiko 神戸大学, 保健学研究科, 保健学研究員 (40566121)
OKIMURA Yasuhiko 神戸女子大学, 家政学部, 教授 (30204100)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 集中治療医学 / IL-18 / 敗血症 / エンドトキシン / インスリン / 血糖値 / 性差 |
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| Research Abstract |
The purpose of this study was to evaluate the effects of endogenous IL-18 and its gender difference on inflammation-related insulin resistance. The endogenous IL-18 might inhibit hyperglycemia and hyperinsulinemia during acute inflammation. The plasma insulin concentration was higher in male than in female mice, however, the relation of IL-18 to this gender differencve has not been elucidated clearly yet. Further studies are needed to investigate the role ofendogenous IL-18 on the gender difference in inflammation-related insulin resistance.
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