| Project/Area Number |
23659854
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAGUCHI Akira 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00142430)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨細胞 / 脊椎動物 / 力学的負荷 / 進化 / 骨 / カルシウム貯蔵庫 / 破骨細胞 / オステオネットワーク |
|---|
| Research Abstract |
We conducted various experiments to understand the mechanism of acquirement of osteonetwork in vertebrates. 1) Bones of zebrafish contained osteocytes (cellular bone) but with a poorly developed osteocyte lacunocanalicular system. Bones of Xenopus laevis, a freshwater species, and of other amphibians, reptiles, and mammals contained numerous osteocytes and a well-developed lacunocanalicular system. 2) Bone in rats acquired the function of mineral storage, but frog bones has not acquire such function.
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