Challenge to clarify the acquirement of osteonetwork
| Project/Area Number |
23659854
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAGUCHI Akira 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00142430)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨細胞 / 脊椎動物 / 力学的負荷 / 進化 / 骨 / カルシウム貯蔵庫 / 破骨細胞 / オステオネットワーク |
|---|
| Research Abstract |
We conducted various experiments to understand the mechanism of acquirement of osteonetwork in vertebrates. 1) Bones of zebrafish contained osteocytes (cellular bone) but with a poorly developed osteocyte lacunocanalicular system. Bones of Xenopus laevis, a freshwater species, and of other amphibians, reptiles, and mammals contained numerous osteocytes and a well-developed lacunocanalicular system. 2) Bone in rats acquired the function of mineral storage, but frog bones has not acquire such function.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Spatiotemporal disorder in endochondral ossification during axial skeleton development in the Mesp2-null mouse: A developmental etiology of spondylocostal dysostosis and spondylothoracic dysostosis.2013
Author(s)
Makino Y, Takahashi Y, Tanabe R, Tamamura Y, Watanabe T, Haraikawa M, Hamagaki M, Hata K, Kanno J, Yoneda T, Saga Y, Goseki-Sone M, Kaneko K, Yamaguchi A, Iimura T
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Journal Title
BONE
Volume: 53
Pages: 248-258
Related Report
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[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development.2012
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
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Journal Title
Mech Dev
Volume: 129
Pages: 38-50
Related Report
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[Journal Article] Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.2012
Author(s)
Nishimura R, Wakabayashi M, Hata K,Matsubara T, Honma H, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T
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Journal Title
J Biol Chem
Volume: 287
Pages: 33179-33190
Related Report
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[Journal Article] Retention of bone strength by feeding of milk and dairy products in ovariectomized rats; involvement of changes in serum levels of 1alpha, 25(OH)2D3 and FGF23.2012
Author(s)
Tanabe R, Haraikawa M, Sogabe N, Sugimoto A, Kawamura Y, Takasugi S, Nagata M, Nakane A, Yamaguchi A, Iimura T, Masae Goseki-Sone
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Journal Title
J Nutr Biochem
Volume: in press
Issue: 6
Pages: 1000-7
DOI
Related Report
Peer Reviewed
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