| Project/Area Number |
23659855
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IIMURA Tadahiro 東京医科歯科大学, 歯と骨のGCOE拠点, 特任准教授 (20282775)
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| Co-Investigator(Renkei-kenkyūsha) |
NUMANO Rika 豊橋技術科学大学, 准教授 (30462716)
YAMAGUCHI Akira 東京医科歯科大学, 大学院, 教授 (00142430)
MIYAWAKI Atsushi 独立行政法人理化学研究所, チームリーダー (80251445)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨 / イメージング / 分子時計 / 概日リズム / 発達 / 発光 / 蛍光 |
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| Research Abstract |
Bone metabolism is regulated by circadian clock. On the other hand, the central clock system in brain is thought to regulate peripheral clocks including bone. We established a dual imaging system of bioluminescence and fluorescence, which enables us to monitor circadian oscillation from body to cell levels. By exploiting this system, inter-regulation between brain and bone well be further investigated.
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