Investigation for the bone clock development by bioluminescence and fluorescence imaging on brain and bone
| Project/Area Number |
23659855
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IIMURA Tadahiro 東京医科歯科大学, 歯と骨のGCOE拠点, 特任准教授 (20282775)
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| Co-Investigator(Renkei-kenkyūsha) |
NUMANO Rika 豊橋技術科学大学, 准教授 (30462716)
YAMAGUCHI Akira 東京医科歯科大学, 大学院, 教授 (00142430)
MIYAWAKI Atsushi 独立行政法人理化学研究所, チームリーダー (80251445)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨 / イメージング / 分子時計 / 概日リズム / 発達 / 発光 / 蛍光 |
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| Research Abstract |
Bone metabolism is regulated by circadian clock. On the other hand, the central clock system in brain is thought to regulate peripheral clocks including bone. We established a dual imaging system of bioluminescence and fluorescence, which enables us to monitor circadian oscillation from body to cell levels. By exploiting this system, inter-regulation between brain and bone well be further investigated.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Retention of bone strength by feeding of milk and dairy products in ovariectomized rats; involvement of changes in serum levels of 1alpha, 25(OH)2D3 and FGF23.2012
Author(s)
Tanabe R, Haraikawa M, Sogabe N, Sugimoto A, Kawamura Y, Takasugi S, Nagata M, Nakane A, Yamaguchi A, Iimura T, Masae Goseki-Sone
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Journal Title
J Nutr Biochem
Volume: in press
Issue: 6
Pages: 1000-7
DOI
Related Report
Peer Reviewed
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[Journal Article] CxCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction2012
Author(s)
Oue E, Lee Ji-Won, Sakamoto K, Iimura K, Aoki K, Kayamori K, Michi Y, Yamagshiro M, Harada K, Amagasa T, Yamaguchi A
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Journal Title
Biochem Biophys Res Commun
Volume: 424
Issue: 3
Pages: 456-461
DOI
Related Report
Peer Reviewed
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[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2011
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
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Journal Title
AMech Dev
Volume: (In press)
Issue: 1-4
Pages: 38-50
DOI
Related Report
Peer Reviewed
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