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The involvement and their molecular mechanism of microRNAs in the invasion of oral cancer

Research Project

Project/Area Number 23659858
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionThe University of Tokushima (2012)
Hiroshima University (2011)

Principal Investigator

KUDO Yasusei  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (50314753)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔病理学 / microRNA / 口腔癌 / 浸潤 / 上皮間葉移行(EMT) / EMT
Research Abstract

We identified miR-203 as an invasion related microRNA (miRNA) by comparing miRNA expression profile between oral cancer cell line and its highly invasive clone. Moreover, we identified NUAK and SNAI2 as a target mRNA of miR-203.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (7 results)

  • [Journal Article] Matrix metalloproteinase-13 directly and indirectly promotes tumor angiogenesis2012

    • Author(s)
      Kudo, Y.*, Iizuka, S., Yoshida, M., Tsunematsu, T., Subarnbhesaj, A., Siriwardena, S.B.S.M., Tahara, H., Ogawa, I., Takata, T
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 38716-38728

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer2012

    • Author(s)
      Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena SB, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, Koizumi K, Maeda M, Ishimaru N, Ogawa I, Takata T
    • Journal Title

      PLoS One

      Volume: 7(8) Issue: 8 Pages: e44488-e44488

    • DOI

      10.1371/journal.pone.0044488

    • NAID

      120006714446

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma2012

    • Author(s)
      Desrochers, T.M., Shamis, Y., Alt-Holland, A., Kudo, Y., Takata, T., Wang, G., Jackson-Grusby, L., Garlick, J.A
    • Journal Title

      Epigenetics

      Volume: 7 Pages: 34-46

    • Related Report
      2012 Final Research Report
  • [Journal Article] Matrix metalloproteinase-13 directly and indirectly promotes tumor angiogenesis.2012

    • Author(s)
      Kudo, Y., et al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Pages: 38716-38728

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periostin promotes tumor lymphangiogenesis in a direct and an indirect manner.2012

    • Author(s)
      Kudo, Y., , et al.
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma.2012

    • Author(s)
      Desrochers, T.M., , et al.
    • Journal Title

      Epigenetics

      Volume: 7 Pages: 34-46

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MMP10/stromelysin-2 promotes invasion of head and neck cancer2011

    • Author(s)
      Deraz EM, Kudo Y, Yoshida M, Tani H, Tsunematsu T, et al
    • Journal Title

      PLos ONE

      Volume: (電子媒体) Issue: 10 Pages: e25438-e25438

    • DOI

      10.1371/journal.pone.0025438

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] miR-22 represses cancer progression by inducing celular senescence2011

    • Author(s)
      Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., Tamaki, A., Takata, T., Shimamoto, A., Ochiya, T., Tahara, H
    • Journal Title

      J Cell Biol

      Volume: 193(2) Pages: 409-424

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MMP-10/stromelysin-2 promotes invasion of head and neck cancer.2011

    • Author(s)
      Deraz EM, Kudo Y, Yoshida M, Obayashi M, Tsunematsu T, Tani H, Siriwardena SB, Keikhaee MR, Qi G, Iizuka S, Ogawa I, Campisi G, Lo Muzio L, Abiko Y, Kikuchi A, Takata T.
    • Journal Title

      PLoS ONE

      Volume: 6

    • NAID

      120005300499

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] miR-22 represses cancer progression by inducing cellular senescence.2011

    • Author(s)
      Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A, Ochiya T, Tahara H.
    • Journal Title

      J Cell Biol.

      Volume: 193 Pages: 409-424

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma2012

    • Author(s)
      Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T
    • Organizer
      第23回日本臨床口腔病理学会・学術大会
    • Place of Presentation
      東京都(東京医科歯科大学)
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203 の同定2012

    • Author(s)
      大林真理子,吉田真希,工藤 保誠, 高田 隆
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市(ロイトン札幌)
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203の同定2012

    • Author(s)
      大林真理子,他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌ロイトンホテル(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma.2012

    • Author(s)
      Nguyen PT, , et al.
    • Organizer
      第23回日本臨床口腔病理学会・学術大会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of microRNA-203 as an inhibitor of invasion in oral cancer2011

    • Author(s)
      Obayashi M, Kudo Y, Yoshida M, Hino Y, Fukunaga S, Tahara H, Takata T
    • Organizer
      59thJADR Annual Meeting
    • Place of Presentation
      広島市(広島国際会議場)
    • Year and Date
      2011-08-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203 の同定2011

    • Author(s)
      大林真理子,工藤保誠,吉田真希,日野由美子,福永早央里,田原栄俊,高田 隆
    • Organizer
      第3回 RNAi 研究会
    • Place of Presentation
      広島市(広島プリンスホテル)
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203 の同定2011

    • Author(s)
      大林真理子,工藤保誠,吉田真希,日野由美子,福永早央里,田原栄俊,高田 隆
    • Organizer
      第30回分子病理学研究会
    • Place of Presentation
      倉敷市(下電ホテル)
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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