Molecular Regulation of Bone Formation in Jaw

• Project/Area Number: 23659868
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NODA Masaki 東京医科歯科大学, 難治疾患研究所, 教授 (50231725)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯科薬理学 / TRPV4 / 副甲状腺ホルモン / 顎骨 / 骨芽細胞 / 骨粗鬆症

Research Abstract

Jaw bone is important for mastification. However, the mechanism underlying the maintenance of jaw bone has not been fully understood. We have examined the role of TRPV4 in the regulation of bone mass especially in jaw bone. In the presence of TRPV4, jaw bone is maintained, while the absence of TRPV4 suppressed the levels of bone mass in jaw bone specifically as it did not change the levels of bone mass in parietal bone. TRPV4 gene expression is enhanced by differentiation of osteoblasts as well as the treatment with BMP2. TRPV4 is activated not only by it’s agonist but also fluid flow as a mechanical stress. These data indicate that jaw bone is regulated by TRPV4 for its maintenance of the bone mass.

Research Products

• [Journal Article] Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force (2013)
  • Author(s): Takafumi Suzuki
  • Journal Title: Bone Volume: 54(1) Issue: 1 Pages: 172-8
  • DOI: 10.1016/j.bone.2013.01.001
  • Peer Reviewed
• [Journal Article] Nck1 Deficiency Accelerates Unloading-Induced Bone Loss (2013)
  • Author(s): Aryal A. C. S, Miyai K, Hayata T, Notomi T, Nnakamoto T, Pawson T, Ezura Y, Noda M.
  • Journal Title: Journal of Cellular Physiology Volume: 228 Issue: 7 Pages: 1397-403
  • DOI: 10.1002/jcp.24317
  • Peer Reviewed
• [Journal Article] Identification of two pore channel 2 as a novel regulator of osteoclastogenesis (2012)
  • Author(s): Takuya Notomi
  • Journal Title: Journal of Biological Chemistry Volume: 287(42) Issue: 42 Pages: 35057-64
  • DOI: 10.1074/jbc.m111.328930
  • Peer Reviewed
• [Journal Article] Profilin1 regulates sternum development and endochondral bone formation. (2012)
  • Author(s): Miyajima D, Noda M
  • Journal Title: Journal of Biological Chemistry Volume: 287(40) Pages: 33545-53
  • Peer Reviewed
• [Journal Article] Anabolic action of parathyroid hormone regulated by the beta2-adrenergic receptor (2012)
  • Author(s): Hanyu, R.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 109 Issue: 19 Pages: 7433-7438
  • DOI: 10.1073/pnas.1109036109
  • Peer Reviewed
• [Journal Article] CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells (2012)
  • Author(s): Sakuma, T., Nakamoto, T., Hemmi, H., Kitazawa, S., Kitazawa, R., Notomi, T., Hayata, T., Ezura, Y., Amagasa, T., and Noda, M
  • Journal Title: Journal of cellular physiology Volume: 227 Issue: 7 Pages: 2807-2812
  • DOI: 10.1002/jcp.24066
  • Peer Reviewed
• [Journal Article] Treml4, an Ig Superfamily Member, Mediates Presentation of Several Antigens to T Cells In Vivo, Including Protective Immunity to HER2 Protein (2012)
  • Author(s): Hiroaki Hemmi, Neeha Zaidi, Bei Wang, Ines Matos, Christopher Fiorese, Ashira Lubkin, Lori Zbytnuik, Koji Suda, Kenneth Zhang, Masaki Noda, Tsuneyasu Kaisho, Ralph M. Steinman, and Juliana Idoyaga
  • Journal Title: J Immunol Volume: 188 Issue: 3 Pages: 1147-1155
  • DOI: 10.4049/jimmunol.1102541
  • Peer Reviewed
• [Journal Article] Type VI collagen deficiency induces osteopenia with distortion of osteoblastic cell morphology (2012)
  • Author(s): Izu, Y., Ezura, Y., Mizoguchi, F., Kawamata, A., Nakamoto, T., Nakashima, K., Hayata, T., Hemmi, H., Bonaldo, P., and Noda, M
  • Journal Title: Tissue & cell Volume: 44 Issue: 1 Pages: 1-6
  • DOI: 10.1016/j.tice.2011.08.002
  • Peer Reviewed
• [Journal Article] Constitutively active PTH/PTHrP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation (2012)
  • Author(s): Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, Kronenberg HM, Noda M
  • Journal Title: Journal of Cellular Physiology Volume: 227 Issue: 2 Pages: 408-415
  • DOI: 10.1002/jcp.22986
  • Peer Reviewed
• [Journal Article] Profilin1 regulates sternum development and endochondral bone formation (2012)
  • Author(s): Daisuke Miyajima
  • Journal Title: Journal of Biological Chemistry Volume: 287(40) Pages: 33545-53
  • Peer Reviewed
• [Journal Article] Sympathetic control of bone mass regulated by osteopontin (2011)
  • Author(s): Nagao, M., Feinstein, T. N., Ezura, Y., Hayata, T., Notomi, T., Saita, Y., Hanyu, R., Hemmi, H., Izu, Y., Takeda, S., Wang, K., Rittling, S., Nakamoto, T., Kaneko, K., Kurosawa, H., Karsenty, G., Denhardt, D. T., Vilardaga, J. P., and Noda, M
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Issue: 43 Pages: 17767-17772
  • DOI: 10.1073/pnas.1109402108
  • Peer Reviewed
• [Journal Article] MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss (2011)
  • Author(s): Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M
  • Journal Title: J Cell Biochem Volume: 112(12) Issue: 12 Pages: 3525-30
  • DOI: 10.1002/jcb.23327
  • Peer Reviewed
• [Journal Article] Dok-1 and Dok-2 deficiency induces osteopenia via regulation of osteoclasts (2011)
  • Author(s): Aya Kawamata
  • Journal Title: J. Cell. Physiol. Volume: 226 Issue: 12 Pages: 3087-3093
  • DOI: 10.1002/jcp.22909
  • Peer Reviewed
• [Journal Article] Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology (2011)
  • Author(s): Morishita, M., Ono N., Miyai, K., Nakagawa, T., Hanyu, R., Nagao, M.,Kamolratanakul, P., Notomi, T., Rittling, S. R., Denhardt, D. T., Kronenberg, H. M., Ezura, Y., Hayata, T., Nakamoto, T., and Noda, M
  • Journal Title: Tissue & cell Volume: 43 Issue: 3 Pages: 196-200
  • DOI: 10.1016/j.tice.2011.02.003
  • Peer Reviewed
• [Journal Article] Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl (2011)
  • Author(s): 黒川峰夫, 他
  • Journal Title: Cancer Science Volume: 102 Issue: 12 Pages: 2109-2117
  • DOI: 10.1111/j.1349-7006.2011.02066.x
  • Peer Reviewed
• [Journal Article] Per-1 is a specific clock gene regulated byparathyroid hormone (PTH) signaling in osteoblasts and is functional for the transcriptional events induced by PTH (2011)
  • Author(s): Hanyu, R., Hayata, T., Nagao, M., Saita, Y., Hemmi, H., Notomi, T., Nakamoto, T., Schipani, E., Knonenbery, H., Kaneko, K., Kurosawa, H., Ezura, Y., Noda, M
  • Journal Title: J Cell Biochem Volume: 112 Issue: 2 Pages: 433-438
  • DOI: 10.1002/jcb.22957
  • Peer Reviewed
• [Journal Article] Nanogel-Based Scaffold Delivery of Prostaglandin E2 Receptor-Specific Agonist in Combination With a Low Dose of Growth Factor Heals Critical-Size Bone Defects in Mice (2011)
  • Author(s): P.Kamolratanakul, et al
  • Journal Title: Arthritis and Rheumatism Volume: 63 Issue: 4 Pages: 1021-1033
  • DOI: 10.1002/art.30151
  • Peer Reviewed
• [Journal Article] Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy (2011)
  • Author(s): Nagao, M., Saita, Y., Hanyu, R., Hemmi, H., Notomi, T., Hayata, T., Nakamoto, T., Nakashima, K., Kaneko, K., Kurosawa, H., Ishii, S., Ezura, Y., Noda, M
  • Journal Title: J Cell Physiol Volume: 226 Issue: 3 Pages: 573-538
  • DOI: 10.1002/jcp.22521
  • Peer Reviewed
• [Journal Article] Sympathetic control of bone mass regulated by osteopontin (2011)
  • Author(s): Masashi Nagao
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108(43) Pages: 17767-72
  • Peer Reviewed
• [Journal Article] Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy (2011)
  • Author(s): Masashi Nagao
  • Journal Title: Journal of Cellular Physiology Volume: 226 Pages: 573-578
  • Peer Reviewed
• [Journal Article] Osteopontin deficiency enhances parathyroid hormone/parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology (2011)
  • Author(s): Maki Morishita
  • Journal Title: Tissue and Cell Volume: 43 Pages: 196-200
  • Peer Reviewed
• [Presentation] 骨粗鬆症とテリパラチド (2013)
  • Author(s): 野田政樹
  • Organizer: 栃木県骨粗鬆症フォーラム
  • Place of Presentation: 栃木日本
  • Year and Date: 2013-02-27
• [Presentation] 廃用性骨委縮のメカニズム (2012)
  • Author(s): 野田政樹
  • Organizer: 第18回埼玉県骨粗鬆症研究会
  • Place of Presentation: 埼玉日本
  • Year and Date: 2012-11-10
• [Presentation] 不動性骨粗鬆症のメカニズムOsteopontinBiology (2012)
  • Author(s): 野田政樹
  • Organizer: 第14回日本骨粗鬆症学会骨ドック・健診分科会
  • Place of Presentation: 新潟日本
  • Year and Date: 2012-09-27
• [Presentation] Limb-and sternum-specific inactivation of Dullard gene causes severe defects in skeletal development via alteration of TGF-s signaling (2012)
  • Author(s): Hayata T, Noda M
  • Organizer: 1st Asia-Pacific Bone and Mineral Research Meeting with the ANZBMS 22nd Annual Scientific Meeting
  • Place of Presentation: Perth, Australia
  • Year and Date: 2012-09-25
• [Presentation] Analysis of high turnover type bone loss due tohaploinsufficiency of Cnot3, a subunit of Ccr4-not complex(mRNA seadenylase) (2012)
  • Author(s): Watanabe C, Noda M
  • Organizer: 1st Asia-Pacific Bone and Mineral Research Meeting with the ANZBMS 22nd Annual Scientific Meeting
  • Place of Presentation: Perth, Australia
  • Year and Date: 2012-09-25
• [Presentation] Osteopontin Biology in Bone (2012)
  • Author(s): 野田政樹
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Saxtons River, VT, USA
  • Year and Date: 2012-08-05
• [Presentation] 骨の力学的刺激への応答性の制御機構 (2012)
  • Author(s): 野田政樹
  • Organizer: 昭和大学歯学部歯科矯正学教室
  • Place of Presentation: 東京日本
  • Year and Date: 2012-02-21
• [Presentation] Parathyroid hormone stimulates Tob1 expressionin osteoblastic cells in vitro and in vivo (2012)
  • Author(s): Moriya S, Noda M
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] PTH Enhances Mechanical Stress-iduced Osteoblast Proliferation in Calvarial Derived Osteoblasts via Up-regulation of CyclinD1 Expression (2012)
  • Author(s): Shirakawa J, Noda M
  • Organizer: The 34thAnnual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] The expression of Ift88 is dose-dependently decreased in cultured chondrocytes ATDC5 when treated with TGF-〓1 (2012)
  • Author(s): Kawasaki M, Noda M
  • Organizer: The 34th Annual Meeting of AmericanSociety for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Cnot3(Ccr4-not complex subunit3), a regulator of mRNA stability, regulates bone mass and gene expressionrelated to osteoclast formation (2012)
  • Author(s): Watanabe C, Noda M
  • Organizer: The34th Annual Meeting of AmericanSociety for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Nck, an actin cytoskeleton modulator, controls expression of osteocytic genes, phosphate homeostasis by regulating FGF 23 expression in bone and maintains bone mass (2012)
  • Author(s): Aryal S, Noda M
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Lysosomal calcium channel, TPC2, regulates osteoclastogenesis via generation of intracellular Ca2+ response and subsequent NFATc1 localization: a novel mechanism of osteoclastic Ca2+ signaling (2012)
  • Author(s): Notomi T, Noda M
  • Organizer: The 34th Annual Meeting of American Society for Bone andMineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Limb- and Sternum-Specific Inactivation of Dullard Gene Causes Severe Defects in Skeletal Development viaAlteration of TGF-s Signaling (2012)
  • Author(s): Hayata T, Noda M
  • Organizer: The34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Chondrocyte Metabolism in Inflammatory Arthritis is regulated by CIZ (2012)
  • Author(s): Nakamoto T, Noda M
  • Organizer: The 34th Annual Meeting of American Society for Bone andMineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Identification of Signature Genes Selectively Expressed in Mesenchymal Stem Cells Derived from Synovial Joint Tissues (2012)
  • Author(s): Ezura Y, Noda M
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Cnot3 (Ccr4-not complex subunit 3) controls bone mass via regulating expression of genes including those related to osteoclastic activity (2012)
  • Author(s): Watanabe C, Noda M
  • Organizer: The 2ndTri-University Consortium on Oral Science and Education
  • Place of Presentation: Beijing, China
• [Presentation] 他β2アドレナリン受容体によるPTH受容体シグナル制御の解析 (2012)
  • Author(s): 平林恭子、野田政樹
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪日本
• [Presentation] 他骨芽細胞におけるGタンパク質共役型受容体(GPCR)によるRANKL制御の検討GPC Rcontrol of RANKL expression in osteoblasts (2012)
  • Author(s): 守屋秀一、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他PTH及びメカニカルストレスによる骨芽細胞におけるサイクリンD1発現の検討Expression of cyclin D1 in osteoblasts by PTH and mechanical stress (2012)
  • Author(s): 白川純平、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他一次繊毛タ ンパクBbs3は骨代謝に関与するCiliary protein Bbs3 is involved in bone metabolism (2012)
  • Author(s): 川崎真希理、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他骨芽細胞におけるアクチン細胞骨格調整因子、Nckの欠損は骨芽細胞の遊走と骨形 成を阻害す Deficiency of Nck, an Actin Cytoskeleton Modulator in the Osteoblast Inhibits Osteoblast Migration and Suppresses Bone Formation (2012)
  • Author(s): Smriti Aryal A.C、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他骨量制御の新転写後性分子機構:mRNA deadenylase である Ccr4-not complex 構成因子Cnot3 の欠失による高回転型の骨量減 少の解析 Molecular mechanisms underlying mRNA stability in bone metabolism:Role of Ccr4-not complex subnuit3(Cnot3) (2012)
  • Author(s): 渡辺千穂、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他Two PoreChannel 2 を介したリソソーム由来Ca2+による新たな破骨細胞分化制御機構 Lysosomal calcium channel, TPC2, regulates osteoclastogenesis via regulation of intracellular calcium response (2012)
  • Author(s): 納富拓也、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他PTH の骨形成促進作用はシャトリングタンパク質CIZによって抑制される Anabolic Action of PTH/PTHrP Receptor Signaling in Bone is Suppressed by a Nucleocytoplasmic Shuttling ProteinCIZ (2012)
  • Author(s): 中元哲也、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他四肢及び胸骨特異的Dullard遺伝子欠損マウスは骨化遅延を示すLimb- andSternum-Specific Inactivation of Dullard Gene Causes Retardation of Ossification (2012)
  • Author(s): 早田匡芳、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] 他ヒト骨髄および滑膜由来間葉系細胞において異なるCpGメチル化を示す遺伝子群の探索 と骨軟骨細胞分化の制御に関わる転写 因子群の抽出:RUNX2 および RUNX3,DLX5, ALX4 遺伝子 Identification of Differentially Methylated Transcription Factor Genes in theHuman Synovium and Bone Marrow Derived Mesenchymal Cells: RUNX2, RUNX3, DLX5, and ALX4Genes (2012)
  • Author(s): 江面陽一、野田政樹
  • Organizer: 第30回日本骨代謝学会
• [Presentation] Cnot3 (Ccr4-not complex subunit 3) controls bone mass via regulating expression of genes including those related to osteoclastic activity (2012)
  • Author(s): Chiho Watanabe
  • Organizer: The 2nd Tri-University Consortium on Oral Science and Education
  • Place of Presentation: Beijing, China
• [Presentation] Analysis of high turnover type bone loss due to haploinsufficiency of Cnot3, a subunit of Ccr4-not complex(mRNA seadenylase) (2012)
  • Author(s): Chiho Watanabe
  • Organizer: 1st Asia-Pacific Bone and Mineral Research Meeting with the ANZBMS 22nd Annual Scientific Meeting
  • Place of Presentation: Perth, Australia
• [Presentation] Limb- and sternum-specific inactivation of Dullard gene causes severe defects in skeletal development via alteration of TGF-ß signaling (2012)
  • Author(s): Tadayoshi Hayata
  • Organizer: 1st Asia-Pacific Bone and Mineral Research Meeting with the ANZBMS 22nd Annual Scientific Meeting
  • Place of Presentation: Perth, Australia
• [Presentation] Chondrocyte Metabolism in Inflammatory Arthritis is regulated by CIZ (2012)
  • Author(s): Tetsuya Nakomoto
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Limb- and Sternum-Specific Inactivation of Dullard Gene Causes Severe Defects in Skeletal Development via Alteration of TGF-ß Signaling (2012)
  • Author(s): Tadayoshi Hayata
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Lysosomal calcium channel, TPC2, regulates osteoclastogenesis via generation of intracellular Ca2+ response and subsequent NFATc1 localization: a novel mechanism of osteoclastic Ca2+ signaling (2012)
  • Author(s): Takuya Notomi
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Cnot3(Ccr4-not complex subunit3), a regulator of mRNA stability, regulates bone mass and gene expression related to osteoclast formation (2012)
  • Author(s): Chiho Watanabe
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] The expression of Ift88 is dose-dependently decreased in cultured chondrocytes ATDC5 when treated with TGF-β1 (2012)
  • Author(s): Makiri Kawasaki
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] PTH Enhances Mechanical Stress-iduced Osteoblast Proliferation in Calvarial Derived Osteoblasts via Up-regulation of CyclinD1 Expression (2012)
  • Author(s): Jumpei Shirakawa
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] Parathyroid hormone stimulates Tob1 expression in osteoblastic cells in vitro and in vivo (2012)
  • Author(s): Shuichi Moriya
  • Organizer: The 34th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, MN, USA
• [Presentation] ヒト骨髄および滑膜由来間葉系細胞において異なるＣｐＧメチル化を示す遺伝子群の探索と骨軟骨細胞分化の制御に関わる転写因子群の抽出：RUNX2 およびRUNX3, DLX5, ALX4遺伝子 (2012)
  • Author(s): 江面陽一
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] 四肢及び胸骨特異的Dullard遺伝子欠損マウスは骨化遅延を示す (2012)
  • Author(s): 早田匡芳
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] PTHの骨形成促進作用はシャトリングタンパク質CIZによって抑制される (2012)
  • Author(s): 中元哲也
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] Two Pore Channel 2を介したリソソーム由来Ca2+による新たな破骨細胞分化制御機構 (2012)
  • Author(s): 納富拓也
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] 骨量制御の新転写後性分子機構：mRNA deadenylaseである Ccr4-not complex構成因子Cnot3の欠失による高回転型の骨量減少の解析 (2012)
  • Author(s): 渡辺千穂
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] 骨芽細胞におけるアクチン細胞骨格調整因子、Nckの欠損は骨芽細胞の遊走と骨形成を阻害す (2012)
  • Author(s): Smriti Aryal A.C
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] 一次繊毛タンパクBbs3は骨代謝に関与する (2012)
  • Author(s): 川崎真希理
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] PTH及びメカニカルストレスによる骨芽細胞におけるサイクリンD1発現の検討 (2012)
  • Author(s): 白川純平
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] 骨芽細胞におけるGタンパク質共役型受容体(GPCR)によるRANKL制御の検討 (2012)
  • Author(s): 守屋秀一
  • Organizer: 第30回日本骨代謝学会
  • Place of Presentation: 東京 日本
• [Presentation] β2アドレナリン受容体によるPTH受容体シグナル制御の解析 (2012)
  • Author(s): 平林恭子
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪 日本
• [Presentation] 骨の力学的刺激への応答性の制御機構 (2012)
  • Author(s): 野田政樹
  • Organizer: 昭和大学 歯学部歯科矯正学教室 特別講義 (招待講演）(招待講演)
  • Place of Presentation: 東京 日本
• [Presentation] Control of OsteoblasticFunction via Local and Central Mechanisms (2011)
  • Author(s): 野田政樹
  • Organizer: The American Society for Cell Biology Annual Meeting
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2011-12-03
• [Presentation] 骨のメカニカルストレス応答の細胞生物学 (2011)
  • Author(s): 野田政樹
  • Organizer: 第19回顎顔面バイオメカニクス学会大会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-11-13
• [Presentation] BMPにおける骨形成とEP4 (2011)
  • Author(s): 野田政樹
  • Organizer: 第18回BMP研究会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-07-31
• [Presentation] 骨粗鬆症の新しい治療 (2011)
  • Author(s): 野田政樹
  • Organizer: 並区医師会整形外科医会講演会
  • Place of Presentation: 東京日本
  • Year and Date: 2011-05-23
• [Presentation] Anabolic action of PTH signaling on bone activated expression of a clock gene, Per-1 (2011)
  • Author(s): Hanyu R, Noda M
  • Organizer: The 1st International Academyof Sportology
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-03-05
• [Presentation] Expression of Ift88, a Cilia Component Gene, is Under Temporal Regulation Along with the Differentiation ofChondrocytic Cell Line ATDC5 (2011)
  • Author(s): Kawasaki M, Noda M
  • Organizer: The33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Cnot3, aCrucial Factor of mRNA Stability, Controls Osteoblastic Differentiation (2011)
  • Author(s): Watanabe C, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] TRPV4Deficiency Suppresses Fluid Flow Induced Activation of Calcium Oscillation in a Manner Dependent on Osteoblastic Differentiation (2011)
  • Author(s): Suzuki T, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: SanDiego, CA, USA
• [Presentation] Conditional Profilin1 Deficiency inMultiple Cell Linages of Mesenchyme Origin Based on Prx1-Cre System Severely Disrupts Axial and Appendicular Skeletal Development (2011)
  • Author(s): Miyajima D, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Nck Actin Cytoskeleton Protein, Supports Osteoblastic Bone Increment and Suppresses Osteoclastic Bone Loss (2011)
  • Author(s): Aryal S, Noda M
  • Organizer: The 33rd Annual Meeting of AmericanSociety for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Role of CIZ in Melanoma Activity for Metastasis (2011)
  • Author(s): Sakuma T, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Sympathetic Control of Bone Mass Regulated By Osteopontin (2011)
  • Author(s): Nagao M, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Boneand Mineral Research
  • Place of Presentation: San Diego, CA,USA
• [Presentation] Opto-Functional Control of Intracellular RANKl Transport/Secretion in Osteoblasts to Enhance Coupling With Osteoclasts Based on Photo-Energy Conversion of Molecularly-EngineeredChannel-Rhodopsin (2011)
  • Author(s): Notomi T, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Dullard Is aNovel Common Negative Regulator ofBMP Signaling in Osteoblasts and Chondrocytes Acting at Smad1 Level Independently ofCaveolae-Proteasome Pathway (2011)
  • Author(s): Hayata T, Noda M
  • Organizer: The33rd Annual Meeting of AmericanSociety for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Molecular Mechanism of CIZ Actions to Exacerbate Inflammation inSerum-induced Arthritis Based onFormation of Positive Feedback Loop with IL-1 Beta (2011)
  • Author(s): Nakamoto T, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Identification of the Differentially Methylated Promoter and Intronic CpG Sites in the Human Synovium and Bone Marrow Derived Mesenchymal Stem Cells (2011)
  • Author(s): Ezura Y, Noda M
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Inactivation of Dullard in the mouse limb and sternum displays reatrdatio of ossification in sdeletogenesis (2011)
  • Author(s): Hayata T, Noda M
  • Organizer: KEY Forum in Developmental Biology and Regenerative Medicine-Supported by Global COE and IMEG
  • Place of Presentation: Kumamoto University, Kumamoto, Japan
• [Presentation] Sympathetic control of bone mass regulated by osteopontin (2011)
  • Author(s): Nagao M, Noda M
  • Organizer: The 93rd Annual Meeting& Expo
  • Place of Presentation: Boston, MA, USA
• [Presentation] 他四肢-胸郭間葉系細胞における Profilin1欠失マウスは重度骨格形成不全を示すProfilin1-deficient mice inlimb-thoracis mesenchyme exhibit severe defects in skeletal development (2011)
  • Author(s): 宮嶋大輔、野田政樹
  • Organizer: 第56回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 大阪日本
• [Presentation] 他悪性黒色腫細胞の転移におけるCIZの促進的作用 (2011)
  • Author(s): 佐久間朋美、野田政樹
  • Organizer: 第65回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 東京、日本
• [Presentation] Control of Osteoblastic Function via Local and Central Mechanisms (2011)
  • Author(s): Masaki Noda
  • Organizer: The American Society for Cell Biology Annual Meeting (招待講演）(招待講演)
  • Place of Presentation: Denver, CO, USA
• [Presentation] 骨のメカニカルストレス応答の細胞生物学 (2011)
  • Author(s): 野田政樹
  • Organizer: 第19回顎顔面バイオメカニクス学会大会 特別講演(招待講演)
  • Place of Presentation: 大阪 日本
• [Presentation] BMPにおける骨形成とEP4 (2011)
  • Author(s): 野田政樹
  • Organizer: 第18回BMP研究会 特別講演(招待講演)
  • Place of Presentation: 大阪 日本
• [Presentation] 骨粗鬆症の新しい治療 (2011)
  • Author(s): 野田政樹
  • Organizer: 杉並区医師会整形外科医会 講演会(招待講演)
  • Place of Presentation: 東京 日本
• [Presentation] Sympathetic control of bone mass regulated by osteopontin (2011)
  • Author(s): Masashi Nagao
  • Organizer: The 93rd Annual Meeting & Expo
  • Place of Presentation: Boston, MA, USA
• [Presentation] Molecular Mechanism of CIZ Actions to Exacerbate Inflammation in Serum-induced Arthritis Based on Formation of Positive Feedback Loop with IL-1 Beta (2011)
  • Author(s): Tetsuya Nakamoto
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Dullard Is a Novel Common Negative Regulator of BMP Signaling in Osteoblasts and Chondrocytes Acting at Smad1 Level Independently of Caveolae-Proteasome Pathway (2011)
  • Author(s): Tadayoshi Hayata
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Opto-Functional Control of Intracellular RANKl Transport/Secretion in Osteoblasts to Enhance Coupling With Osteoclasts Based on Photo-Energy Conversion of Molecularly-Engineered Channel-Rhodopsin (2011)
  • Author(s): Takuya Notomi
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Sympathetic Control of Bone Mass Regulated By Osteopontin (2011)
  • Author(s): Masashi Nagao
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Nck, Actin Cytoskeleton Protein, Supports Osteoblastic Bone Increment and Suppresses Osteoclastic Bone Loss (2011)
  • Author(s): Aryal Smriti
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Conditional Profilin1 Deficiency in Multiple Cell Linages of Mesenchyme Origin Based on Prx1-Cre System Severely Disrupts Axial and Appendicular Skeletal Development (2011)
  • Author(s): Daisuke Miyajima
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] TRPV4 Deficiency Suppresses Fluid Flow Induced Activation of Calcium Oscillation in a Manner Dependent on Osteoblastic Differentiation (2011)
  • Author(s): Takafumi Suzuki
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Cnot3, a Crucial Factor of mRNA Stability, Controls Osteoblastic Differentiation (2011)
  • Author(s): Chiho Watanabe
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Expression of Ift88, a Cilia Component Gene, is Under Temporal Regulation Along with the Differentiation of Chondrocytic Cell Line ATDC5 (2011)
  • Author(s): Makiri Kawasaki
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, CA, USA
• [Presentation] 悪性黒色腫細胞の転移におけるCIZの促進的作用 (2011)
  • Author(s): 佐久間 朋美
  • Organizer: 第65回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 東京 日本
• [Presentation] 四肢-胸郭間葉系細胞におけるProfilin1欠失マウスは重度骨格形成不全を示す (2011)
  • Author(s): 宮嶋 大輔
  • Organizer: 第56回（社）日本口腔外科学会総会・学術大会
  • Place of Presentation: 大阪 日本
• [Presentation] Osteopontin Biology in Bone
  • Author(s): Masaki Noda
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Saxtons River, VT, USA
  • Invited
• [Presentation] 不動性骨粗鬆症のメカニズムOsteopontin Biology
  • Author(s): 野田政樹
  • Organizer: 第14回日本骨粗鬆症学会 骨ドック・健診分科会 特別講演
  • Place of Presentation: 新潟 日本
  • Invited
• [Presentation] 廃用性骨委縮のメカニズム
  • Author(s): 野田政樹
  • Organizer: 第18回埼玉県骨粗鬆症研究会 特別講演
  • Place of Presentation: 埼玉 日本
  • Invited
• [Presentation] 骨粗鬆症とテリパラチド
  • Author(s): 野田政樹
  • Organizer: 栃木県骨粗鬆症フォーラム 特別講演
  • Place of Presentation: 栃木 日本
  • Invited
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/section/advanced/mp/index.html
• [Remarks] 骨粗鬆症の為の骨を作るメカニズムの発見2012年4月24日東京医科歯科大学プレスリリース
  • URL: http://www.tmd.ac.jp/press-release/20120419/index.html