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Identification of genes involved in biological crosstalk between cancer and bone

Research Project

Project/Area Number 23659870
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

YONEDA Toshiyuki  大阪大学, 歯学研究科, 招へい教員 (80142313)

Co-Investigator(Renkei-kenkyūsha) HATA Kenji  大阪大学, 歯学研究科, 准教授 (80444496)
TANAKA Soichi  大阪大学, 歯学研究科, 助教 (20548200)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨転移 / 乳癌細胞 / 骨微小環境 / 微小環境 / 乳がん
Research Abstract

Crosstalk between cancer cells and bone microenvironments is critical to the development and progression of bone metastases. To determine the molecular basis of bone metastasis, we attempted to uncover the molecules that are expressed in breast cancer cells under the influences of bone microenvironments. We have identified 154 genes by microarray analysis. We found that docking protein NEDD9 that is up-regulated by bone-derived TGF・・is critical to the development of bone metastasis. Further determination of the function of genes identified by this study may lead to design new molecular therapeutic approaches for the treatment of bone metastasis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (16 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases2012

    • Author(s)
      Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, Yoshikawa H, Rosen CJ, Mundy GR,Yoneda T
    • Journal Title

      Cancer Research

      Volume: 72 Pages: 4238-4249

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Iwaya K, Kikuchi R, Kobayashi T, Yoneda T, Nishikawa, Matsubara O, Kohno N.2012

    • Author(s)
      Stathmin is involved in the cooperative effect of zoledronic acid and gefitinib on bone homing breastcancer cells in vitro Oda M
    • Journal Title

      J Bone Oncol

      Volume: 1 Pages: 40-46

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases.2012

    • Author(s)
      Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, Yoshikawa H, Rosen CJ, Mundy GR, Yoneda T
    • Journal Title

      Cancer Research

      Volume: 72 Pages: 4238-4249

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stathmin is involved in the cooperative effect of zoledronic acid and gefitinib on bone homing breast cancer cells in vitro.2012

    • Author(s)
      Oda M, Iwaya K, Kikuchi R, Kobayashi T, Yoneda T, Nishikawa, Matsubara O, Kohno N.
    • Journal Title

      J Bone Oncol

      Volume: 1 Pages: 40-46

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nishisho T, Hata K, Nakanishi M, Morita Y, Sun-Wada GH, Wada Y, Yasui N, Yoneda T.2011

    • Author(s)
      The a3 isoform vacuolar type ATPase promotes distant metastasis in the mouse B16 melanoma cells
    • Journal Title

      Mol Cancer Res

      Volume: 9(7) Pages: 845-855

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells.2011

    • Author(s)
      Nishisho T, Hata K, Nakanishi M, Morita Y, Sun-Wada GH, Wada Y, Yasui N, Yoneda T.
    • Journal Title

      Mol Cancer Res

      Volume: 9(7) Pages: 845-855

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 骨内での癌細胞の上皮間葉転換EMTにおける脱ユビキチン化酵素USP45の役割2012

    • Author(s)
      田中宗一
    • Organizer
      第15回癌と骨病変研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨転移の分子メカニズム2012

    • Author(s)
      米田俊之
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨転移メカニズムとそのマネージメント2012

    • Author(s)
      米田俊之
    • Organizer
      第57回日本口腔外科学会総会・学術大会
    • Place of Presentation
      横浜(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] The De-ubiquitinating Enzyme USP45 Is Critical to Epithelial-mesenchymal Transition (EMT) in Breast Cancer Cells Colonized Bone2012

    • Author(s)
      Soichi Tanaka, Kenji Hata, Toshiyuki Yoneda
    • Organizer
      米国骨代謝学会
    • Place of Presentation
      ミネアポリス
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨微小環境と癌2012

    • Author(s)
      米田俊之
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨は癌の隠れ家2012

    • Author(s)
      米田俊之
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨転移メカニズムとそのマネージメント2012

    • Author(s)
      米田俊之
    • Organizer
      第57回日本口腔外科学会総会・学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨転移の分子メカニズム2012

    • Author(s)
      米田俊之
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨微小環境と癌2012

    • Author(s)
      米田俊之
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨は癌の隠れ家2012

    • Author(s)
      米田俊之
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The adaptor protein NEDD9 is a novel regulator of cancer and bone crosstalk in breast cancermetastasis to bone2011

    • Author(s)
      Kenji Hata, Yoshihiro Morita, Jin Mushiake,Masako Nakanishi, Toshihiko Nishisho, Toshiyuki Yoneda
    • Organizer
      2011 CIBD meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] NEDD9は乳がん細胞の上皮間葉転換を促進す2011

    • Author(s)
      波多賢二, 森田祥弘,中西雅子,西庄俊彦,虫明仁, 由良義明,米田俊之
    • Organizer
      る癌と骨病変研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨は癌細胞のチューター2011

    • Author(s)
      米田俊之
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] NEDD9は乳がん細胞の上皮間葉転換を促進する2011

    • Author(s)
      波多賢二, 森田祥弘,中西雅子,西庄俊彦,虫明 仁, 由良義明,米田俊之
    • Organizer
      癌と骨病変研究会
    • Place of Presentation
      東京千代田放送会館
    • Related Report
      2011 Research-status Report
  • [Presentation] The adaptor protein NEDD9 is a novel regulator of cancer and bone crosstalk in breast cancer metastasis to bone2011

    • Author(s)
      Kenji Hata, Yoshihiro Morita, Jin Mushiake, Masako Nakanishi, Toshihiko Nishisho, Toshiyuki Yoneda
    • Organizer
      2011 CIBD meeting
    • Place of Presentation
      シカゴ
    • Related Report
      2011 Research-status Report
  • [Presentation] 骨はがん細胞のチューター2011

    • Author(s)
      米田俊之
    • Organizer
      第29回日本骨代謝学会学術集会(招待講演)
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2011 Research-status Report
  • [Book] がん骨転移のバイオロジーとマネージメント2012

    • Author(s)
      米田俊之、田中宗一、波多賢二
    • Publisher
      医薬ジャーナル
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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