| Project/Area Number |
23659872
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TAKIGAWA Masaharu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
HATTORI Takako 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)
NISHIDA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
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| Co-Investigator(Renkei-kenkyūsha) |
AOYAMA Eriko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | LRP-1 / protein transport / transcytosis / CCN family / CCN2/CTGF / cartilage / トランスサートーシス / 軟骨 / タンパク質輸送 / 変異動物 / 骨格異常 / CTGF?CCN2 / トランスサイトーシス / 輸送 |
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| Research Abstract |
Protein transportation in cartilage has been believed to be due to diffusion because there is no blood vessel in cartilage. In the present study, we revealed that low-density lipoprotein receptor-related protein-1(LRP-1) transports connective tissue growth factor/CCN family 2 (CTGF/CCN2/CCN2)in cartilage by transcytosis, indicating that this mechanism is a new protein transport system in cartilage. We also uncovered that cartilage-specific defect of LRP-1 resulted in skeletal disorders.
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