Eftective detection of extranodal spread-positive squamous cellcarcinoma nodes using hypoxia tracer

• Project/Area Number: 23659881
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nagasaki University
• Principal Investigator: NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
• Co-Investigator(Kenkyū-buntansha): SUMI Misa 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (90284702) ; HOTOKEZAKA Yuka 長崎大学, 大学病院, 講師 (10244089) ; KATAYAMA Ikuo 長崎大学, 大学病院, 助教 (80295089) ; TAGAWA Kazuo 長崎大学, 大学病院, 診療放射線技師 (00380931) ; SASAKI Miho 長崎大学, 大学病院, 助教 (10437874) ; EIDA Sato 長崎大学, 大学院・医歯薬学総合研究科, 助教 (80325662) ; ICHIKAWA Yoko 長崎大学, 大学病院, 助教 (90380857) ; 角 忠輝 長崎大学, 医歯(薬)学総合研究科, 助教 (80284701)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: HYPOXIA / リンパ節転移節外進展

Research Abstract

US and MR imaging was retrospectively evaluated for differentiating ENS-positive (n = 28) from ENS-negative (n = 26) SCC nodes (>10 mm short-axis diameter) in 50 patients with head and neck SCCs. The nodal sizes of ENS-positive nodes (21 ± 9 mm) were significantly larger than those of ENS-negative SCC nodes (14 ± 4 mm) (p =22 mm) and imaging criteria (irregular margin or flare sign) best discriminated ENS-positive SCC nodes with 82% sensitivity, 89% specificity, and 85% accuracy for US and 89% sensitivity, 81% specificity, and 85% accuracy for MR imaging. We conclude that US and MR imaging is useful for the effective detection of ENS-positive nodes in the neck of patients with head and neck SCCs.

Research Products

• [Journal Article] Comparison between ultrasonography and MR imaging for discriminating squamous cell carcinomanodes with extranodal spread in the neck (2012)
  • Author(s): Katayama I, Sasaki M, Kimura Y,Hotokezaka Y,Eida S, Tashiro S, Sumi M, Nakamura T
  • Journal Title: Eur J Radiol Volume: 81巻 Pages: 3326-3331
  • Peer Reviewed
• [Journal Article] Comparison between ultrasonography and MR imaging for discriminating squamous cell carcinoma nodes with extranodal spread in the neck. (2012)
  • Author(s): Katayama I, Sasaki M, Kimura Y, Hotokezaka Y, Eida S, Tashiro S, Sumi M, Nakamura T
  • Journal Title: European Journal of Radiology Volume: 81 Issue: 11 Pages: 3326-3331
  • DOI: 10.1016/j.ejrad.2012.06.018
  • Peer Reviewed
• [Journal Article] Extranodal spread in the neck : MR imaging detection on the basis of pixel-based time-sienal intensity curve analysis (2011)
  • Author(s): Sumi M, Nakamura T
  • Journal Title: J Magn Reson Imaging Volume: 33 Issue: 4 Pages: 830-838
  • DOI: 10.1002/jmri.22454
  • Peer Reviewed
• [Presentation] 胞性病変・膿瘍のADC (2011)
  • Author(s): 中村 卓
  • Organizer: 日本歯科放射線学会 第31回関西・九州合同地方会
  • Place of Presentation: 今池ガスビル7階B会議室
  • Year and Date: 2011-12-10
• [Presentation] cPLA2 コンディショナル・ノックアウトマウスの作成 (2011)
  • Author(s): 中村 卓
  • Organizer: 日本歯科放射線学会 第31回関西・九州合同地方会
  • Place of Presentation: 今池ガスビル7階B会議室
  • Year and Date: 2011-12-10
• [Presentation] 頸部囊胞性病変・膿瘍のADC (2011)
  • Author(s): 中村 卓
  • Organizer: 日本歯科放射線学会 第31回関西・九州合同地方会
  • Place of Presentation: 今池ガスビル7階Ｂ会議室
• [Presentation] ｃPLA2 コンディショナル・ノックアウトマウスの作成 (2011)
  • Author(s): 中村 卓
  • Organizer: 日本歯科放射線学会 第31回関西・九州合同地方会
  • Place of Presentation: 今池ガスビル7階Ｂ会議室