| Project/Area Number |
23659883
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
HIRAGA TORU 松本歯科大学, 歯学部, 准教授 (70322170)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOYA Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌 / 骨転移 / 前転移ニッチ |
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| Research Abstract |
In the present study, we examined whether the changes in bone marrow cell population in tumor-bearing mice affect the development of bone metastases. Both in the bone marrow in the tumor-bearing mice and in the bone marrow with tumor metastases, the ratio of Gr-1+/CD11b+ cells was markedly increased. Furthermore, the inoculation of tumor cells with Gr-1+/CD11b+ cells isolated from tumor-bearing mice enhanced the formation of subcutaneous tumors. However, bone metastases were not increased in the presence of subcutaneous tumors. Further studies are required to fully define the relationship between bone marrow Gr-1+/CD11b+ cells and the development of bone metastases.
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