Chimeric PLAG-immunoglobulin protein-induced anti-tumor immune response
| Project/Area Number |
23659884
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Yukinari 東北大学, 医学部, 教授 (00571811)
TANIGUCHI Kunihisa 福岡歯科大学, 歯学部, 教授 (90105685)
TSURUGA Eichi 福岡歯科大学, 歯学部, 教授 (30295901)
HATAKEYAMA Yuji 福岡歯科大学, 歯学部, 講師 (40302161)
OKA Kyoko 福岡歯科大学, 歯学部, 講師 (60452778)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 実験腫瘍学 / 免疫療法 / 口腔扁平上皮癌 / ポドプラニン / 抗体 / 口腔癌 |
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| Research Abstract |
We developed novel rat antibodies specific for human and mouse podoplanin (NZ-1.2, PMab-1) sold by MBL, Imgenex, Sigma, and Millipore. The antibodies suppressed the growth of podoplanin positive tumor cells transplanted under mouse buccal mucosa and the effect enhanced in mice immunized with podoplanin peptide. Podoplanin may useful molecule for immunotherapy of cancer.
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Report
(3 results)
Research Products
(63 results)
