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Immobilization of collagen using adhesive monomer and guided formation of highly mineralized hybrid "Super Dentin"

Research Project

Project/Area Number 23659886
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAGAMI Jyunji  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50171567)

Co-Investigator(Kenkyū-buntansha) SHIMADA Yasushi  東京医科歯科大学, 助教 (60282761)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords保存修復学 / 接着性モノマー / コラーゲン / POs-Ca / ICP発光分光分析 / 光干渉断層計 / 歯質接着モノマー
Research Abstract

The objectives of this study were to examine the capacity of the dental adhesive monomer to react with type I collagen and evaluate the potential on the mineralization.10-MDP (10-methacryloxydecyl dihydrogen phosphate) ethanol solution and a self-etch dental adhesive primer that contains 10-MDP (Calerfil SE Bond Primer) wereemployed in this study, either of which was applied to type I collagen sponge derived from porcine dermis. The samples including control were divided into 4 groups in compliance with the pH of the liquid (pH 5-5.5 or pH 8-8.5) and experimental period (1 day or 10 days), and immersed into the mineralization solution. After the immersion, mineral density of type I collagen was measured quantitatively using inductively coupled plasma atomic emission spectroscopy (ICP-AES). X-ray diffraction (XRD) was used for the qualitative analysis on the mineral deposition. TEM observation wasadditionally performed on the mineralized collagen morphologically. The results indicated that when MDP processing is applied to type I collagen, first calcium is adsorbed by MDP, an amorphous salt is then produced, and after a length of time depending on the pH of the mineralization fluid, this salt is converted to DCPD and hydroxyapatite.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Monitoring remineralization of enamel subsurface lesions by optical coherence tomography.2013

    • Author(s)
      Mandurah MM, Sadr A, Shimada Y, Kitasako Y, Nakashima S, Bakhsh TA, Tagami J, Sumi Y.
    • Journal Title

      Journal of Biomedical Optics

      Volume: 18(4) Pages: 46006-46006

    • Related Report
      2012 Final Research Report
  • [Journal Article] Monitering remineralization of enamel subsurface lesions by optical coherence tomography2013

    • Author(s)
      Mandurah MM
    • Journal Title

      Journal of Biomedical Optics

      Volume: 18 Pages: 1-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enamel lesion remineralization evaluated by nanoindentation and optical coherence tomography2013

    • Author(s)
      Mandurah M, Sadr A, Nakashima S, Bakhsh T, Shimada Y, Tagami J, Sumi Y.
    • Organizer
      IADR general session
    • Place of Presentation
      Seattle
    • Related Report
      2012 Final Research Report
  • [Presentation] Non-destructive evaluation of internal cavity adaptation in class II resin composite2013

    • Author(s)
      Bakhsh TA, Sadr A, Shimada Y, Mandurah M, Alsayed EZ, Tagami J, Sumi Y.
    • Organizer
      IADR general session
    • Place of Presentation
      Seattle
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of several subpopulations of DCs in rodent dental pulp2013

    • Author(s)
      Aramaki O, Kawashima N, Shimada Y, Suzuki N, Otsuki M, SudaH, Tagami J.
    • Organizer
      IADR general session
    • Place of Presentation
      Seattle
    • Related Report
      2012 Final Research Report
  • [Presentation] Enamel lesion remineralization evaluated by nanoindentation and optical coherence tomography2013

    • Author(s)
      Mandurah M
    • Organizer
      IADR general session
    • Place of Presentation
      シアトル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Non-destructive evaluation of internal cavity adaptation in class II resin composite2013

    • Author(s)
      Bakhsh TA
    • Organizer
      IADR general session
    • Place of Presentation
      シアトル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of several subpopulations of DCs in rodent dental pulp2013

    • Author(s)
      Aramaki O
    • Organizer
      IADR general session
    • Place of Presentation
      シアトル
    • Related Report
      2012 Annual Research Report
  • [Presentation] エナメル質表層部の POs-Ca ならびに POs-Ca+F による再石灰化:ナノインデンテーション及び SS-OCT による評価2012

    • Author(s)
      マンドウラモナ、サダルアリレザ、北迫勇一、中嶋省志、島田康史、田上順次、角保徳、田中智子.
    • Organizer
      日本歯科保存学会春季学術大
    • Related Report
      2012 Final Research Report
  • [Presentation] エナメル質表層部のPos-CaならびにPOs-Ca+Fによる再石灰化:ナノインデンテーション及びSS-OCTによる評価2012

    • Author(s)
      マンドウラモナ
    • Organizer
      第136回日本歯科保存学会春季学術大会
    • Place of Presentation
      宜野湾市
    • Related Report
      2012 Annual Research Report
  • [Presentation] I型コラーゲンの接着モノマー修飾と石灰化ハイブリッドの誘導形成2011

    • Author(s)
      島田康史、市野瀬志津子、Sadr Alireza、Nazari Amir、中川寿一、田上順次、Eidelman Naomi、高木章三、Chow C Laurence.
    • Organizer
      日本歯科保存学会 2011年度春季学術大会
    • Related Report
      2012 Final Research Report
  • [Presentation] I型コラーゲンの接着モノマー修飾と石灰化ハイブリッドの誘導形成2011

    • Author(s)
      島田康史、市ノ瀬志津子、SadrAlireza、NazariAmir、中川寿一、田上順次、Eidelman Naomi、高木章三、Chow C Laurence
    • Organizer
      日本歯科保存学会2011年度春季学術大会(第134回)
    • Place of Presentation
      浦安市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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