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Investigation of mechanism on obstruction of osseointegration caused by micro movement by occlusion

Research Project

Project/Area Number 23659893
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionHokkaido University

Principal Investigator

ATSURO Yokoyama  北海道大学, 歯学研究科(研究院), 教授 (20210627)

Co-Investigator(Kenkyū-buntansha) YASUDA Motoaki  北海道大学, 大学院歯学研究科, 准教授 (90239765)
YAMAMOTO Satoru  北海道大学, 大学院歯学研究科, 助教 (10344524)
AMIZUKA Norio  北海道大学, 大学院歯学研究科, 教授 (30242431)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsオッセオインテグレーション / インプラント / 咬合負荷 / 即時埋入 / 組織化学 / マイクロアレイ / デンタルインプラント / 遺伝子発現 / 咬合 / リモデリング / 即時インプラント / 免疫組織化学 / 骨関連タンパク / 骨改造
Outline of Final Research Achievements

The purpose of this study is to investigate effects of micro movement by occlusion on osseointegration. Left first molars of maxillae in rats were extracted, and then, titanium screws were immediately inserted into the sockets. After 1 week of the implantation, occlusal loading was provided for 1 or 2 weeks in the experimental groups. Histochemical and histomorphometric assessment and analysis of gene expression by microarray were carried out. Trabecular thickness of the experimental group was thicker than the control group. The index of sclerostin-positive osteocytes located close to the implants bearing 2 weeks’ loading was significantly attenuated compared with the control group, indicating undisturbed activities of osteoblasts. Microarray analysis showed that gene expression for bone formation and BMP were higher in the experimental group. It was suggested that the early occlusal loading for immediate implant accelerate osseointegration.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 2013

All Presentation (4 results)

  • [Presentation] ラット上顎の抜歯即時埋入後に早期荷重を行ったチタンインプラント周囲骨の組織学的検索2015

    • Author(s)
      池田欣希、長谷川智香、山内貴紀子、網塚憲生、横山敦郎
    • Organizer
      第124回日本補綴歯科学会学術大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2015-05-30 – 2015-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抜歯即時埋入後の早期荷重がチタンインプラント周囲骨組織に与える影響2014

    • Author(s)
      池田欣希、山内貴紀子、横山敦郎
    • Organizer
      第44回日本口腔インプラント学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biologic effects of early occlusal loading on bone tissue around titanium implants immediately placed into extraction sockets2014

    • Author(s)
      Ikeda Y, Hasegawa T, Amizuka N, Yokoyama A.
    • Organizer
      The 9th Scientific Meeting of the Asian Academy of Osseointegration
    • Place of Presentation
      札幌市教育文化会館(北海道札幌市)
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 咬合負荷が抜歯即時埋入チタンインプラント周囲の骨組織に与える影響について2013

    • Author(s)
      池田欣希、長谷川智香、網塚憲正、横山敦郎
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岡山市コンベンションセンター(岡山市)
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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