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Tailor-made bone regeneration as a pre-prosthodontic treatment based on the concept of tissue engineering triad

Research Project

Project/Area Number 23659902
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionKyushu University

Principal Investigator

AYUKAWA Yasunori  九州大学, 大学病院, 講師 (50304697)

Co-Investigator(Kenkyū-buntansha) KOYANO Kiyoshi  九州大学, 大学院・歯学研究院, 教授 (50195872)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords骨再生 / テーラーメイド医療 / ティッシュエンジニアリング / 補綴前処置
Research Abstract

According to the principle of tissue engineering triad, cells, bioactive molecules, and scaffold are thought to be essential for regeneration. From this point, it is supposed that not every site expected to augment bone tissue requires same element.From the results of our experiments, the local application of both osteoblast-differentiation factor and osteoblast-proliferation factor could induce bone formation. But the bone induced by the former represented more mineralized bone than that induced by the latter. In addition, osteoblast-differentiation factor stimulated the Smad-signaling pathway in the osteoblast-like cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013 2011

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] Bone regeneration of rat tibia defects with enzymatically hydrogelation of gelatin derivative and recombinant human platelet-derived growth factor-BB complex2013

    • Author(s)
      Kondo D, Ogino Y, Ayukaya Y, Sakai S, Kawakami K, Koyano K
    • Journal Title

      Int J Oral Maxillofac Implants

    • Related Report
      2012 Final Research Report
  • [Presentation] 酵素硬化型ゼラチン-血小板由来増殖因子複合体のインジェクション投与は低侵襲な骨増生に有効である2011

    • Author(s)
      近藤大介、荻野洋一郎、鮎川保則、古谷野潔
    • Organizer
      第41回日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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