Tailor-made bone regeneration as a pre-prosthodontic treatment based on the concept of tissue engineering triad

Research Project

Project/Area Number	23659902
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Prosthetic dentistry
Research Institution	Kyushu University
Principal Investigator	AYUKAWA Yasunori 九州大学, 大学病院, 講師 (50304697)
Co-Investigator(Kenkyū-buntansha)	KOYANO Kiyoshi 九州大学, 大学院・歯学研究院, 教授 (50195872)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	骨再生 / テーラーメイド医療 / ティッシュエンジニアリング / 補綴前処置
Research Abstract	According to the principle of tissue engineering triad, cells, bioactive molecules, and scaffold are thought to be essential for regeneration. From this point, it is supposed that not every site expected to augment bone tissue requires same element.From the results of our experiments, the local application of both osteoblast-differentiation factor and osteoblast-proliferation factor could induce bone formation. But the bone induced by the former represented more mineralized bone than that induced by the latter. In addition, osteoblast-differentiation factor stimulated the Smad-signaling pathway in the osteoblast-like cells.