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Evaluation of regions related to pain sensitization in the central nervous system for fibromyalgia patients using fMRI

Research Project

Project/Area Number 23659904
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionKyushu University

Principal Investigator

TSUKIYAMA Yoshihiro  九州大学, 大学院・歯学研究院, 准教授 (10236870)

Co-Investigator(Kenkyū-buntansha) YOSHUIUA Takashi  九州大学, 大学院・歯学研究院, 准教授 (40322747)
NAKAMURA Yasuhiko  九州大学, 大学病院, 診療放射線技師長 (00380494)
KOYANO Kiyoshi  九州大学, 大学院・歯学研究院, 教授 (50195872)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsfMRI / 線維筋痛症 / 筋筋膜痛 / 慢性疼痛 / 痛覚過敏 / 疼痛過敏
Research Abstract

Six fibromyalgia and seven sever myofascial pain patients, and six healthy volunteers participated in this study. Measurement of functional magnetic resonance imaging (fMRI)for the whole brain was carried out before and after the therapeutic intervention, i.e., insertion of oral splint device. The analysis of fMRI data revealed that some patients exhibited the increased brain activities in primary somatosensory area, secondary somatosensory area, cingulate gyrus, and midbrain regions.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (12 results) (of which Invited: 3 results) Book (4 results)

  • [Journal Article] Brain activation during oral exercises used for dysphagia rehabilitation in healthy human subjects: A functional magnetic resonance imaging study2012

    • Author(s)
      Ogura E, Matsuyama M, Goto KT, Nakamura Y, Koyano K
    • Journal Title

      Dysphagia

      Volume: 27 Pages: 353-360

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pain questionnaire development focusing on cross-cultural equivalence to the original questionnaire: The Japanese version of the Short-Form McGill Pain Questionnaire2012

    • Author(s)
      Arimura T, Hosoi M, Tsukiyama Y, et al
    • Journal Title

      Pain Med

      Volume: 13 Pages: 541-551

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rehabilitation of occlusion - science or art?2012

    • Author(s)
      Koyano K, Tsukiyama Y, Kuwatsuru R
    • Journal Title

      J Oral Rehabil

      Volume: 39 Pages: 513-521

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bio-psycho-social assessment of occlusal dysaesthesia patients2012

    • Author(s)
      Tsukiyama Y, Yamada A, Kuwatsuru R, Koyano K
    • Journal Title

      J Oral Rehabil

      Volume: 39 Pages: 623-629

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain activation during oral exercises used for dysphagia rehabilitation in healthy human subjects: A functional magnetic resonance imaging study.2012

    • Author(s)
      Ogura E, Matsuyama M, Goto KT, Nakamura Y, Koyano K
    • Journal Title

      Dysphagia

      Volume: 27 Issue: 3 Pages: 353-360

    • DOI

      10.1007/s00455-011-9374-9

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pain questionnaire development focusing on cross-cultural equivalence to original questionnaire : the Japanese version of the Short-Form McGill Pain Questionnaire2012

    • Author(s)
      Arimura T, Hosoi M, Tsukiyama Y, Yoshida T, Fujiwara D, Tanaka M, Tamura R, Nakashima Y, Sudo N, Kubo C
    • Journal Title

      Pain Medicine

      Volume: 13-4(Epub ahead of print) Issue: 4 Pages: 541-551

    • DOI

      10.1111/j.1526-4637.2012.01333.x

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rehabilitation of occlusion – science or art?2012

    • Author(s)
      Koyano K, Tsukiyama Y, Kuwatsuru R
    • Journal Title

      J Oral Rehabil

      Volume: 39 Issue: 7 Pages: 513-521

    • DOI

      10.1111/j.1365-2842.2012.02303.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bio-psycho-social assessment of occlusal dysaesthesia patients.2012

    • Author(s)
      Tsukiyama Y, Yamada A, Kuwatsuru R, Koyano K
    • Journal Title

      J Oral Rehabil

      Volume: 39 Issue: 8 Pages: 623-629

    • DOI

      10.1111/j.1365-2842.2012.02317.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines and recommendations for assessment of somatosensory function in orofacial pain conditions - a taskforce report2011

    • Author(s)
      Svensson P, Baad-Hansen L, Pigg M, List T, Eliav E, Ettlin D, Michelotti A, Tsukiyama Y, et al
    • Journal Title

      J Oral Rehabil

      Volume: 38 Pages: 366-394

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines and recommendations for assessment of somatosensory function in orofacial pain conditions - a taskforce report.2011

    • Author(s)
      Svensson P, Baad-Hansen L, Pigg M, List T, Eliav E, Ettlin D, Michelotti A, Tsukiyama Y, ほか5名
    • Journal Title

      J Oral Rehabil

      Volume: 38 Pages: 366-394

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 顎関節症の原因,結果,それとも併存症(comorbidity)?2012

    • Author(s)
      築山能大
    • Organizer
      日本顎関節学会第32回学術講演会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2012-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎関節症に関する最先端の臨床研究2012

    • Author(s)
      築山能大
    • Organizer
      日本線維筋痛症学会第4回学術集会
    • Place of Presentation
      長崎市(シンポジウム)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎関節症の症状を呈する他の疼痛性疾患との鑑別2012

    • Author(s)
      築山能大
    • Organizer
      第25回日本顎関節学会学術大会
    • Place of Presentation
      札幌市(教育講演)
    • Year and Date
      2012-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎関節症の症状を呈する他の疼痛性疾患との鑑別2012

    • Author(s)
      築山能大
    • Organizer
      第25回日本顎関節学会学術大会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 顎関節症に関する最先端の臨床研究2012

    • Author(s)
      築山能大
    • Organizer
      日本線維筋痛症学会第4回学術集会
    • Place of Presentation
      長崎市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 顎関節症の原因,結果,それとも併存症(comorbidity)?2012

    • Author(s)
      築山能大
    • Organizer
      日本顎関節学会第32回学術講演会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 咬合感覚異常症の特徴と補綴学的対応2011

    • Author(s)
      築山能大
    • Organizer
      平成23年度日本補綴歯科学会九州支部学術大会
    • Place of Presentation
      長崎市(招待講演)
    • Year and Date
      2011-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] DFNS-QSTの口腔領域への応用2011

    • Author(s)
      松香芳三,築山能大
    • Organizer
      2011年度日本口腔顔面痛学会第2回セミナー神経傷害時の定量感覚検査(QST)に関する研究会(第1報)
    • Place of Presentation
      吹田市(シンポジウム)
    • Year and Date
      2011-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparison of brain activity during gum and paraffin- chewing2011

    • Author(s)
      Ogura E, Matsuyama M, Shimada T, Tsukiyama Y, Koyano K
    • Organizer
      14th Meeting of the International College of Prosthodontists
    • Place of Presentation
      Hawaii (Poster presentation)
    • Year and Date
      2011-09-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 咬合感覚異常症の特徴と補綴学的対応2011

    • Author(s)
      築山能大
    • Organizer
      平成23年度日本補綴歯科学会九州支部学術大会(招待講演)(招待講演)
    • Place of Presentation
      長崎県歯科医師会館(長崎市)
    • Related Report
      2011 Research-status Report
  • [Presentation] DFNS-QSTの口腔領域への応用2011

    • Author(s)
      松香芳三,築山能大
    • Organizer
      2011年度日本口腔顔面痛学会第2回セミナー神経傷害時の定量感覚検査(QST)に関する研究会(第1報)(シンポジウム)(招待講演)
    • Place of Presentation
      大阪大学(吹田市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Ogura E, Matsuyama M, Shimada T, Tsukiyama Y, Koyano K2011

    • Author(s)
      Ogura E, Matsuyama M, Shimada T, Tsukiyama Y, Koyano K
    • Organizer
      14th Meeting of the International College of Prosthodontists
    • Place of Presentation
      Hilton Waikoloa Village(Hawaii)
    • Related Report
      2011 Research-status Report
  • [Book] AADR のTMD Policy Statement(TMDに関する基本声明)からTMDの基本を読み解くIn TMD YEAR BOOK 2012 アゴの痛みに対処するAADRの基本声明から現代のTMD臨床を読み解く2012

    • Author(s)
      古谷野潔,築山能大,桑鶴利香
    • Publisher
      クインテッセンス出版
    • Related Report
      2012 Final Research Report
  • [Book] TMD YEAR BOOK 2012 アゴの痛みに対処する AADRの基本声明から現代のTMD臨床を読み解く2012

    • Author(s)
      古谷野潔,桑鶴利香,築山能大
    • Total Pages
      207
    • Publisher
      クインテッセンス出版
    • Related Report
      2012 Annual Research Report
  • [Book] TMDとその周辺にある疾病を理解する.In TMD YEAR BOOK 2011 アゴの痛みに対処する その原因,検査・鑑別診断,歴史と患者説明2011

    • Author(s)
      古谷野潔,桑鶴利香,築山能大
    • Publisher
      クインテッセンス出版
    • Related Report
      2012 Final Research Report
  • [Book] TMD YEAR BOOK 2001 アゴの痛みに対処する その原因,検査・鑑別診断,歴史と患者説明2011

    • Author(s)
      古谷野潔,桑鶴利香,築山能大
    • Total Pages
      186
    • Publisher
      クインテッセンス出版
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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