| Project/Area Number |
23659906
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMOTO Tetsuji 九州歯科大学, 歯学部, 准教授 (30514989)
MASAKI Chihiro 九州歯科大学, 歯学部, 助教 (60397940)
KONDO Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | インクレチン / 咀嚼機能的評価 / 血糖値コントロール / 糖尿病 / 補綴治療介入 / インスリン / 咀嚼障害 / GLP-1 / 義歯 / インプラント |
|---|
| Research Abstract |
Glucagon-like peptide 1(GLP-1) is secreted from the small intestine to the blood in response to glucose intake during a meal, and it stimulates pancreatic insulin secretion. To investigate the relationship between chewing and postprandial blood glucose related to incretin secretion, we compared the levels following usual eating with the changes of blood glucose, serum insulin, and plasma active GLP-1 concentrations after young healthy volunteers ate a test meal in one of three specified ways : 1.unilateral chewing, 2.quick eating, 3.30 times chewing per one bite. Ten volunteers participated in each group. There were no differences in the blood glucose or insulin concentrations between usual eating and the three specified ways of eating. Plasma active GLP-1 concentration did not change by unilateral chewing or quick eating, but it increased significantly by 30 times chewing per one bite compared with usual eating at 30 minutes after a meal.
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