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A study of a synthetic construct for bone development

Research Project

Project/Area Number 23659909
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

SUZUKI Osamu  東北大学, 大学院・歯学研究科, 教授 (60374948)

Co-Investigator(Kenkyū-buntansha) SHIMAUCHI Hidetoshi  東北大学, 大学院・歯学研究科, 教授 (70187425)
KAMAKURA Shinji  東北大学, 大学院・医工学研究科, 教授 (80224640)
ANADA Takahisa  東北大学, 大学院・歯学研究科, 准教授 (30398466)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords石灰化球 / タンパク質 / 骨再生
Research Abstract

Synthetic calcium phosphates, having a higher adsorption affinity with non-collagenous proteins, such as albumin, were prepared as a source material for an implantable construct. Fluoride-containing calcium phosphates, showing a relatively higher solubility and a higher protein adsorption affinity, were developed. Natural polymer, such as alginate, was used to study for the preparation of the implantable gel form.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Structural, morphological and surface characteristics of two types of octacalcium phosphate-derived fluoride-containing apatitic calcium phosphates2012

    • Author(s)
      Yukari Shiwaku, Takahisa Anada, Hajime Yamazaki, Yoshitomo Honda, Shinji Morimoto, Keiichi Sasaki, Osamu Suzuki
    • Journal Title

      Acta Biomaterialia

      Volume: 8 Issue: 12 Pages: 4417-4425

    • DOI

      10.1016/j.actbio.2012.07.041

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteome analysis of rat serum proteins adsorbed onto synthetic octacalcium phosphate crystals2011

    • Author(s)
      Kaneko H, Kamiie J, Kawakami H, Anada T, Honda Y, Shiraishi N, Kamakura S, Terasaki T, Shimauchi H, Suzuki O
    • Journal Title

      Anal Biochem

      Volume: 418 Issue: 2 Pages: 276-285

    • DOI

      10.1016/j.ab.2011.07.022

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 注入可能なリン酸オクタカルシウム/ヒアルロン酸複合体材料の皮質骨造成効2013

    • Author(s)
      鈴木堅太郎,穴田貴久,今泉秀樹,宮武尚央,井樋栄二,鈴木治
    • Organizer
      第34回東北骨代謝・骨粗鬆症研究会
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report
  • [Presentation] 注入可能なリン酸オクタカルシウム/ヒアルロン酸複合体材料の皮質骨造成効果.2013

    • Author(s)
      鈴木堅太郎, 穴田貴久, 今泉秀樹, 宮武尚央, 井樋栄二, 鈴木治
    • Organizer
      第34回東北骨代謝・骨粗鬆症研究会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] MSCの分化条件の検討とOCP/Colと組み合わせた担体の骨再生能の検討2012

    • Author(s)
      川井忠,穴田貴久,益田泰輔,本田義知,坂井裕大,加藤幸夫,鎌倉慎治,越後成志,鈴木治
    • Organizer
      第33回東北骨代謝研究会
    • Place of Presentation
      仙台
    • Year and Date
      2012-02-04
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] リン酸オクタカルシウム(OCP)のin vitro生体適合性評2012

    • Author(s)
      森元慎二,穴田貴久,本田義知,鈴木治
    • Organizer
      平成24年度秋期第60回日本歯科理工学会学術講演会
    • Place of Presentation
      九州大学(福岡)
    • Related Report
      2012 Final Research Report
  • [Presentation] リン酸オクタカルシウム(OCP)のin vitro生体適合性評価.2012

    • Author(s)
      森元慎二,穴田貴久,本田義知,鈴木治
    • Organizer
      平成24年度秋期第60回日本歯科理工学会学術講演会
    • Place of Presentation
      九州大学(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨ナノミネラル形成環境が調節する骨芽細胞分化2011

    • Author(s)
      鈴木治
    • Organizer
      新世紀世界の成長焦点に築くナノ医工学拠点:第61回グローバルCOE「ナノ医工学シリーズセミナー」(招待講演)
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2011-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨ナノミネラル形成環境が調節する骨芽細胞分化2011

    • Author(s)
      鈴木 治
    • Organizer
      新世紀世界の成長焦点に築くナノ医工学拠点:第61回グローバルCOE「ナノ医工学シリーズセミナー」(招待講演)
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2011 Research-status Report
  • [Book] Interface Oral Health Science 2011. Edits: Sasaki K, Suzuki O, Takahashi N "Hydroxyapatite film for dental treatment by powder jet deposition; A review".2012

    • Author(s)
      Akatsuka R,, Ishihata H, Noji M, Matsumura K, Anada T, Kuriyagawa T,Suzuki O, Sasaki K
    • Publisher
      Springer, Tokyo
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.cfe.dent.tohoku.ac.jp

    • Related Report
      2012 Final Research Report
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野 HP

    • URL

      http://www.cfe.dent.tohoku.ac.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.cfe.dent.tohoku.ac.jp

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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