• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a sophisticated dental implant based on biomimetic engineering

Research Project

Project/Area Number 23659910
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

SHIMAUCHI Hidetoshi  東北大学, 大学院・歯学研究科, 教授 (70187425)

Co-Investigator(Kenkyū-buntansha) ISHIHATA Hiroshi  東北大学, 病院, 助教 (40261523)
NEMOTO Eiji  東北大学, 大学院・歯学研究科, 准教授 (40292221)
KANAYA Sousuke  東北大学, 大学院・歯学研究科, 助教 (80375097)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯科インプラント / 生体模倣(biomimetics) / スキャフォールド / 生体模倣 / デンタルインプラント / チタン表面処理 / ハニカムフィルム
Research Abstract

This study was aimed to develop the new fabrication method that can fabricate an ideal surface structure on implant fixture to control the microscopic surface topography suitable for osseointegration and bone regeneration. For this purpose, we used “micro-dimple imprint method" by applying honeycomb films. We fabricated the regularly arrayed micro-dimple structure on the mirror-like finished surface of Type 1 Ti plate masked with honeycomb film by wet-etching. After the etching, we obtained the regularly arrayed dimples on Ti surface with identical diameter and pitch as a honeycomb mesh structure of the mask. Human periodontal ligament (hPDL) or STRO-1^+dental follicle (STRO-1^+DF) cells were seeded and culture on the honeycomb-fabricated and control Ti. hPDL/ STRO-1^+DF cells showed stimulated proliferation and a unique forms on the fabricated Ti, that is completely different from the uniformed pattern of cell behavior on control Ti surface, suggesting that our newly developed micro-dimple imprint method is useful for the processing of implant fixture surface and fabrication the surface topography at a μm order.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2012 2011 Other

All Presentation (9 results) (of which Invited: 1 results) Book (2 results)

  • [Presentation] development of 20mm micro-pored full titanium membrane for bone augmentation2012

    • Author(s)
      Ishihata H, Nagamine M, Yoshikawa K, Sasaki K, Shimauchi H
    • Organizer
      日本機械学会第24回バイオエンジニアリング 講演会"Japan-Korea joint symposium bioceramics and biomaterials for hard tissue"
    • Place of Presentation
      大阪
    • Year and Date
      2012-01-12
    • Related Report
      2012 Final Research Report
  • [Presentation] チタンメッシュを用いたヒト智歯歯胚由来細胞の培養2012

    • Author(s)
      小林洋子、遠藤直樹、石幡浩志、岩間張良、島内英俊
    • Organizer
      日本歯科保存学会平成24年度秋季学術大会(第137回)
    • Place of Presentation
      広島市
    • Related Report
      2012 Final Research Report
  • [Presentation] Φ0.02mm純チタンマイクロメッシュを用いた歯槽骨再生誘導(GBR)の試み2012

    • Author(s)
      石幡浩志、小林洋子、下西充、遠藤耕生、神田佳明、生宏、高橋健太、宇塚理紗、小泉俊郎、長峰勝、吉川研一、大森整、佐々木啓一、島内英俊
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 歯周組織再生~医療としての現状と課題2012

    • Author(s)
      島内英俊
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台市
    • Related Report
      2012 Final Research Report
  • [Presentation] Micro-pierce Fabricated Titanium Mesh as a New Cell- Interactive Barrier Membrane2012

    • Author(s)
      Shimauchi H, Ishihata H, Yoshikawa K, Nagamine M, Ohmori H, Komatsu M, Sasaki K
    • Organizer
      第98回アメリカ歯周病学会総会
    • Place of Presentation
      ロサンゼ ルス市、アメリカ合衆国
    • Related Report
      2012 Final Research Report
  • [Presentation] Micro-pierce Fabricated Titanium Mesh as a New Cell-Interactive Barrier Membrane2012

    • Author(s)
      SHIMAUCHI H, ISHIHATA H, YOSHIKAWA K, NAGAMINE M, OHMORI H, KOMATSU M, SASAKI K
    • Organizer
      98th Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      ロサンゼルス市、アメリカ合衆国
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯周組織再生 医療としての現状と課題2012

    • Author(s)
      島内英俊
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] チタンメッシュを用いたヒト智歯歯胚由来細胞の培養2012

    • Author(s)
      小林洋子、遠藤直樹、石幡浩志、岩間張良、島内英俊
    • Organizer
      日本歯科保存学会平成24年度秋季学術大会(第137回)
    • Place of Presentation
      広島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of 20 um Micro-pored Full-Titanium Membrane for Bone Argumentation

    • Author(s)
      Ishihata H, Shimauchi H et al
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会 Japan-Korea Joint Symposium"Biomechanics and biomaterials for hard tissue"
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Book] 機械と工具、チタンのマイクロピアース加工-再生医療をリードするものづくり-2011

    • Author(s)
      石幡浩志、長峰勝、島内英俊
    • Publisher
      日本工業出版
    • Related Report
      2012 Final Research Report
  • [Book] 機械と工具、チタンのマイクロピアス加工―再生医療をリードするものづくり―2011

    • Author(s)
      石幡浩志、長峰 勝、島内英俊
    • Publisher
      日本工業出版
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi