Development of the evaluation method without radiation for peri-implantitis
| Project/Area Number |
23659919
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MAKIHIRA SEICHO 九州大学, 歯学研究科(研究院), 准教授 (80304450)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Yoshihiro 九州大学, 歯学研究科(研究院), 教授 (30038898)
篠原 義憲 九州大学, 歯学研究科(研究院), 助教 (00423533)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOHARA Yoshinori (00423533)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | インプラント / インプラント周囲炎 / インプラント予後 / バイオマーカー / 検査法 |
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| Research Abstract |
It was important to develop the evaluation method for peri-implantitis. Mini pure titanium implants (mini-implant) were placed into palatine bone of rats, followed by that lipopolysaccharide derived from Porphyromonas gingivalis (P.g.-LPS) was intermittently injected into the gingival tissues around mini-implant. Inflamed tissues by P.g.-LPS (P.g.-LPS samples) were collected from around mini-implant. The expression patterns of RANKL and OPG in the tissues, which were known as the markers of bone resorption, were examined. P.g.-LPS enhanced the expressions of RANKL in the tissues around mini-implant, as compared with those of control samples without P.g.-LPS. On the other hand, the expressions of OPG in the P.g.-LPS samples were decreased.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin2011
Author(s)
Seicho Makihira, Hiroki Nikawa, Takahiro Shuto, Masahiro Nishimura, Yuichi Mine, Koichiro Tsuji, Keishi Okamoto, Yuhiro Sakai, Masanori Sakai, Naoya Imari, Satoshi Iwata, Mika Takeda, Fumio Suehiro
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Journal Title
Journal of Materials Science : Materials in Medicine
Volume: 22
Pages: 2765-2772
NAID
Related Report
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[Presentation] Inhibition of Cellular Fusion during RANKL-Dependent Osteoclastogenesis by NHE10-specific Monoclonal Antibody2013
Author(s)
Yuichi Mine, Seicho Makihira , Hiroki Nikawa, Toshihisa Kawai T, Masaru Ohara, Kazuko Kawahara, Koji Ohta, Takahiro Shuto, Toshio Kukita, Yoshihiro Terada
Organizer
2^<nd> Meeting of the International Association for Dental Research Asia Pacific Region
Place of Presentation
Bangkok, Thailand
Related Report
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[Presentation] Inhibition of Cellular Fusion during RANKL-Dependent Osteoclastogenesis by NHE10-specific Monoclonal Antibody2013
Author(s)
Yuichi Mine, Seicho Makihira , Hiroki Nikawa, Toshihisa Kawai T, Masaru Ohara, Kazuko Kawahara, Koji Ohta, Takahiro Shuto, Toshio Kukita, Yoshihiro Terada
Organizer
2nd Meeting of the International Association for Dental Research Asia Pacific Region
Place of Presentation
Bangkok, Thailand
Related Report
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[Presentation] 口腔インプラントに固定化した新規塩基性抗菌ペプチド(JH8194)の大型イヌでの骨結合促進効果2011
Author(s)
坂井将典, 竹田美佳, 牧平清超, 西村正宏, 坂井裕大, 首藤崇裕, 峯 裕一, 岩田慧, 今利直也, 末廣史雄, 二川浩樹, 辻 紘一郎
Organizer
第58回日本実験動物学会総会
Place of Presentation
東京
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