| Project/Area Number |
23659919
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MAKIHIRA SEICHO 九州大学, 歯学研究科(研究院), 准教授 (80304450)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
TERADA Yoshihiro 九州大学, 歯学研究科(研究院), 教授 (30038898)
篠原 義憲 九州大学, 歯学研究科(研究院), 助教 (00423533)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOHARA Yoshinori (00423533)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | インプラント / インプラント周囲炎 / インプラント予後 / バイオマーカー / 検査法 |
|---|
| Research Abstract |
It was important to develop the evaluation method for peri-implantitis. Mini pure titanium implants (mini-implant) were placed into palatine bone of rats, followed by that lipopolysaccharide derived from Porphyromonas gingivalis (P.g.-LPS) was intermittently injected into the gingival tissues around mini-implant. Inflamed tissues by P.g.-LPS (P.g.-LPS samples) were collected from around mini-implant. The expression patterns of RANKL and OPG in the tissues, which were known as the markers of bone resorption, were examined. P.g.-LPS enhanced the expressions of RANKL in the tissues around mini-implant, as compared with those of control samples without P.g.-LPS. On the other hand, the expressions of OPG in the P.g.-LPS samples were decreased.
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