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Applying the regenerative medicine to cure the side-effects causing by the chemo/radiation therapy such as oral mucositis

Research Project

Project/Area Number 23659921
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionNagasaki University

Principal Investigator

OKUMURA Teruhito  長崎大学, 大学院・医歯薬学総合研究科, 客員研究員 (50585396)

Co-Investigator(Kenkyū-buntansha) OHBA Seigo  長崎大学, 大学病院, 講師 (80363456)
IKEDA Hisazumi  長崎大学, 大学病院, 講師 (00244088)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords唾液腺再生 / 神経堤細胞 / 相互作用 / 放射線性舌炎 / 細胞治療 / 骨髄由来細胞
Research Abstract

Oral mucositis is a serious and painful side effect for patients with head and neck cancer who received radiation- and/or chemo-therapy. It causes not only the limitation on the ability of patients to tolerate cancer therapies in some cases but also the harmful effects on the quality of life. However, current clinical strategies cannot efficiently prevent the occurrence of oral mucositis. Therefore, effectivetherapy should be developed urgently. BMDCs isolated from male C3H mice were transplanted to the female mice just after the irradiation through the tail vein. After 2, 5, 7 and 11 days of irradiation, the tongues were harvested, and the macroscopic, histological and immunological analyses were performed to clarify the effects of BMDC transplantation. After 2 days of irradiation, the tongues of non-treated mice (IR) showed significant apoptosis of the cells throughout the basal cell layer while few cells were observed in that of BMDCs-treated mice (BM). After 7 days of irradiation, while the ulcer area became maximum in the tongues of IR, the area of ulcers formed in BM specimens was approximately 60% of IR and preserved the epithelial thickness. Consistent with this appearance, histological analysis shows that tongues of BM demonstrated an increased level of tissue regenerative activity such as blood vessel formation and cell proliferation. Finally, after 11 days of irradiation, the area of ulcers in BM decreased remarkably compared with that in IR. Our data suggests that cell therapy with BMDCs can prevent the maximum ulceration caused by head and neck irradiation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2012 2011 Other

All Journal Article (3 results) Presentation (2 results)

  • [Journal Article] Marginal mandibulectomy for lower gingical carcinoma with a cheek-splitting transbuccal approach and reconstruction by buccal fat pad flap: a case report2013

    • Author(s)
      Ohba S, Yamashita H, Takashi I, Asahina I
    • Journal Title

      J Oral Maxillofac Surg

      Volume: vol. 71(2)

    • Related Report
      2012 Final Research Report
  • [Journal Article] In vivo comparison of the bone regeneration capability of human bone marrow concentrates vs platelet-rich plasma2012

    • Author(s)
      fZhong W, Sumita Y, Ohba S, Kawasaki T, Nagai K, Ma G, Asahina I
    • Journal Title

      Plos One

      Volume: vol. 7(7)

    • NAID

      120006985697

    • Related Report
      2012 Final Research Report
  • [Journal Article] Predictive factor for photodynamic therapy effects on oral squamous cell carcinoma and oral epithelial dysplasia2011

    • Author(s)
      Uehara H, Ikeda H, Nonaka M, Sumita Y, Nanashima A, Nonaka T, Asahina I
    • Journal Title

      Arch Oral Biol

      Volume: vol. 56(11) Pages: 1366-72

    • Related Report
      2012 Final Research Report
  • [Presentation] 放射線性の口腔内障害に対する骨髄由来幹細胞治療応用の検討2012

    • Author(s)
      井隆司、住田吉慶、大場誠悟、南里篤太郎、朝比奈泉
    • Organizer
      第57回日本口腔外科学会総会・学 術 大 会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 放射線性口腔粘膜炎に対する骨髄由来細胞治療の可能性について

    • Author(s)
      井隆司
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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