• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of micro-fluid-path type bio -chips using magnetic micro-beads for dental tissue re -generation medicine

Research Project

Project/Area Number 23659923
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionIwate Medical University

Principal Investigator

TAIRA Masayuki  岩手医科大学, 歯学部, 准教授 (60179398)

Co-Investigator(Renkei-kenkyūsha) NEZU Takashi  岩手医科大学, 歯学部, 講師 (40264056)
SASAKI Minoru  岩手医科大学, 歯学部, 准教授 (40187133)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯科医用工学 / マイクロ流路 / 微小ポンプ / 2液混合 / 幹細胞 / 細胞分画 / 混合チップ / 微小ビーズ / 磁性ビーズ / 再生歯学 / バイオチップ / 間葉系幹細胞
Research Abstract

We tried to produce trial micro-fluid-path type bio -chips using Micro Electro Mechanical Systems (MEMS) technology and magnetic micro-beads under development. We examined biding efficiencies between target cells labeled with biotin-conjugated antibodies a nd streptavidin-bound magnetic beads. We obtained partial success in collecting target cells after passing solutions containing antibody -biotin-labeled cells and streptavidin-bound magnetic mico -beads through micro-fluid-paths in trial bio-chips.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (16 results) Remarks (3 results)

  • [Journal Article] Subcutaneous tissue reactions against nano-apatite collagen composites2012

    • Author(s)
      Hatakeyama, W., Taira, M. , Kihara, H., Sasaki, M., Kimura, S. and Kondo, H.
    • Journal Title

      ano Biomedicine

      Volume: 4(2) Pages: 118-124

    • NAID

      130004679846

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analyses of osteogenic-differentiation -related gene expressions in human osteoblasts-like cells (SaOS-2) cultured on hydroxyapatite and titanium. J2012

    • Author(s)
      Taira, M., Hatakeyama, W., Kihara, H., Kondo, H., Ueda, K. and Narushima T.
    • Journal Title

      Oral Tissue Eng

      Volume: 10(1) Pages: 34-41

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analyses of osteogenic-differentiation-related gene expressions in human osteoblasts-like cells (SaOS-2) cultured on hydroxyapatite and titanium.2012

    • Author(s)
      Taira, M., Hatakeyama, W., Kihara, H., Kondo, H., Ueda, K. and Narushima T.
    • Journal Title

      J. Oral Tissue Eng.

      Volume: 10 Pages: 34-41

    • NAID

      130004941076

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous tissue reactions against nano-apatite collagen composites2012

    • Author(s)
      Hatakeyama, W., Taira, M., Kihara, H., Sasaki, M., Kimura, S. and Kondo, H.
    • Journal Title

      Nano Biomedicine

      Volume: 4 Pages: 118-124

    • NAID

      130004679846

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative real-time RT-PCR analyses of DNA-damage-recovery-related gene expressions of mouse macrophage-like cell line RAW264 when exposed to IC50 nickel ions2011

    • Author(s)
      Taira, M., Kagiya, T., Sasaki, M. and Kimura, S
    • Journal Title

      Nano-Biome

      Volume: 3(2) Pages: 294-299

    • NAID

      130004555811

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions2011

    • Author(s)
      Taira M, , Shimoyama Y ., Kagiya T ., Sasaki M., Nezu T., Harada H ., Kimura S.
    • Journal Title

      Dent Mater J

      Volume: 30(3) Pages: 293-299

    • NAID

      10029136627

    • URL

      http://dx.doi.org/10.4012/dmj.2010-088

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative real-time RT-PCR analyses of DNA-damage-recovery-related gene expressions of mouse macrophage-like cell line RAW264 when2011

    • Author(s)
      Taira, M.他3名
    • Journal Title

      Nano-Biomed.

      Volume: 3 Pages: 293-299

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] マイクロ流路チップを用いた細胞と磁性ビーズ溶液の混合に関する研究2013

    • Author(s)
      平 雅之,畠山 航,鬼原 英道,近藤 尚知
    • Organizer
      第61回日本歯科理工学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2013-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔バイオフィルム構成多糖の凝集状態のQCMによる解析2012

    • Author(s)
      根津尚史,佐々木かおり,齋藤設雄,平雅之
    • Organizer
      第60回日本歯科理工学会学術講演会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 多孔質アパタイト粒子コラーゲン複合体によるラット頭蓋骨クリティカルサイズ骨欠損部における骨再生の試み2012

    • Author(s)
      畠山 航,平 雅之,鬼原 英道,近藤 尚知
    • Organizer
      第60回日本歯科理工学会学術講演会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノアパタイト(nano -SHAp)の材料学的評価並びに生体反応評価2012

    • Author(s)
      畠山 航,平 雅之,鬼原 英道,近藤 尚知
    • Organizer
      第59回日本歯科理工学会学術講演会
    • Place of Presentation
      徳島市
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] THP -1細胞を用いたチタン微粒子、銅イオンとTEGDMAモノマーの細胞障害性の評価2011

    • Author(s)
      平 雅之
    • Organizer
      日本動物実験代替法学会 第24回大会
    • Place of Presentation
      Sendai
    • Year and Date
      2011-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオフィルム関連高分子マトリックス中の薬剤透過性の定量評価の試み2011

    • Author(s)
      根津尚史,佐々木かおり,齋藤設雄
    • Organizer
      第58回日本歯科理工学会学術講演会
    • Place of Presentation
      郡山
    • Year and Date
      2011-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] チタンへの金蒸着がチオール化合物の付着に及ぼす影響2011

    • Author(s)
      齋藤設雄,佐々木かおり,根津尚史,平雅之
    • Organizer
      第58回日本歯科理工学会学術講演会
    • Place of Presentation
      郡山
    • Year and Date
      2011-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] TEGDMAに曝された時のTHP -1単球の異物代謝並びに炎症性サイトカイン関連遺伝子の発現評価2011

    • Author(s)
      平 雅之
    • Organizer
      第58回日本歯科理工学会学術講演会
    • Place of Presentation
      郡山
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 剤徐放性コラーゲン基材の調製-架橋法による架橋効率の比較-2011

    • Author(s)
      佐々木かおり,齋藤設雄,根津尚史,平雅之
    • Organizer
      第58回日本歯科理工学会学術講演会
    • Place of Presentation
      郡山
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] マクロファージが銅イオンに暴露された時のmicroRNAの発現について2011

    • Author(s)
      鍵谷忠慶,平 雅之,安藤禎紀,藤村朗
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Histological and TEM observation of subcutaneous tissues exposed to particulate pure metals2011

    • Author(s)
      Saitoh, S., Sasaki, K., Nezu, T. and Taira, M.
    • Organizer
      International Dental Materials Congress 2011 (IDMC2011)
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Diffusion of an antimicrobial acriflavine through a concentrated solution of hyaluronic acid as a matrix component of biofilms2011

    • Author(s)
      Nezu, T., Sasaki, K., Saitoh, S. and Taira, M.
    • Organizer
      International Dental Materials Congress 2011 (IDMC2011)
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] THP-1細胞を用いたチタン微粒子、銅イオンとTEGDMAモノマーの細胞障害性の評価2011

    • Author(s)
      平 雅之
    • Organizer
      日本動物実験代替法学会 第24回大会(招待講演)
    • Place of Presentation
      仙台市
    • Related Report
      2011 Research-status Report
  • [Presentation] マイクロ流路チップを用いた細胞と磁性ビーズ溶液の混合に関する研究

    • Author(s)
      平 雅之,畠山 航,鬼原 英道,近藤 尚知
    • Organizer
      第61回日本歯科理工学会学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 多孔質アパタイト粒子コラーゲン複合体によるラット頭蓋骨クリティカルサイズ骨欠損部における骨再生の試み

    • Author(s)
      畠山 航,平 雅之,鬼原 英道,近藤 尚知
    • Organizer
      第60回日本歯科理工学会学術講演会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノアパタイト(nano-SHAp)の材料学的評価並びに生体反応評価

    • Author(s)
      畠山 航,平 雅之,鬼原 英道,近藤 尚知
    • Organizer
      第59回日本歯科理工学会学術講演会
    • Place of Presentation
      徳島市
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://hitech-d.iwate-med.ac.jp/dmst/index-j.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] 岩手医科大学 医療工学講座のホームページにようこそ

    • URL

      http://hitech-d.iwate-med.ac.jp/dmst/index-j.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://hitech-d.iwate-med.ac.jp/dmst/index-j.htm

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi