Novel oncogenic mechanism of oral cancer mediated by HPV
| Project/Area Number |
23659929
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SATOH Akira 北海道大学, 北海道大学病院, 講師 (90271684)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHINO Humihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
北村 哲也 北海道大学, 歯学研究科(研究院), 助教 (00451451)
樋田 京子 北海道大学, 歯学研究科(研究院), 特任准教授 (40399952)
進藤 正信 北海道大学, 歯学研究科(研究院), 教授 (20162802)
戸塚 靖則 北海道大学, 歯学研究科(研究院), 名誉教授 (00109456)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAMURA Tetuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
HIDA Kyouko 北海道大学, 大学院・歯学研究科, 特任准教 授 (40399952)
TOTSUKA Yasunori 北海道大学, 大学院・歯学研究科, 教授 (00109456)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔外科学一般 / HPV / ARE-mRNA / 口腔がん / E6 / E7 / 核外輸送 / 安定化 |
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| Research Abstract |
In this study, we examined the export and stabilization of ARE-mRNA in oral cancer cells, which is caused by HPV. ARE-mRNA such as c-fos was stabilized in cells mediated by HPV oncogene products E6 and E7. The stabilization of ARE-mRNA in HPV positive cancer cells was down-regulated by HuR knockdown. These findings suggest that ARE-mRNA has some effect on the oncogenesis of cancer cells mediated by HPV.
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Report
(3 results)
Research Products
(27 results)
