Targeting tumor metastasis by normalization of tumor blood vessels
Project/Area Number |
23659930
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
HIDA Kyoko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
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Co-Investigator(Kenkyū-buntansha) |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIDA Yasuhiro 北海道大学, 北海道大学病院, 講師 (30399919)
OHGA Noritaka 北海道大学, 大学院・歯学研究科, 特任助教 (40548202)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 腫瘍血管 / がん / 転移 / 血管新生 |
Research Abstract |
We have isolated two different type of TECs (HM-TEC; isolated from highly metastatic tumor, and LM-TEC; isolated from low metastatic tumor) and found they are different in many aspects. Tumor cells were more attracted and adhesive to HM-TEC in vitro assay. They migrated through the HM-TEC monolayer most among all ECs. To address the question whether TECs contribute to tumor metastasis, low metastatic tumor cells were co-xenografted with each different type of EC (HM-TEC /LM-TEC/NEC) into nude mice. These results suggested that TECs in tumor microenvironment may activelyinduce tumor metastasis.
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Report
(3 results)
Research Products
(71 results)
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[Journal Article] The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma2013
Author(s)
Akiyama K., Ohga N., Maishi N., Hida Y., Kitayama K., Kawamoto T., Osawa T., Suzuki Y., Shinohara N., Nonomura K., Shindoh M., Hida K.
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Journal Title
Pathol. Int.
Volume: 63(1)
Issue: 1
Pages: 37-44
DOI
Related Report
Peer Reviewed
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[Journal Article] Prostacyclin receptor in tumorendothelial cells promotes angiogenesis inan autocrine manner2012
Author(s)
Osawa T., Ohga N., Hida Y ., Kitayama K.,Akiyama K., Onodera Y ., Fujie M.,Shinohara N., Nonomura K., Shindoh M., Hida K.
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Journal Title
Cancer Sci
Volume: 103(6)
Pages: 1038-1044
Related Report
Peer Reviewed
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[Journal Article] Tumor-derivedmicrovesicles induce proangiogenicphenotype in endothelial cells viaendocytosis2012
Author(s)
Kawamoto T., Ohga N., Akiyama K., HirataN., Kitahara S, Maishi N., Osawa T.,Yamamoto K., Kondoh M., Shindoh M.,Hida Y., Hida K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Biglycan is a specific marker and anautocrine angiogenic factor of tumourendothelial cells2012
Author(s)
Y amamoto K., Ohga N., Hida Y ., Maishi N.,Kawamoto T., Kitayama K., Akiyama K.,Osawa T., Kondoh M., Matsuda K.,Onodera Y ., Fujie M., Kaga K., Hirano S,Shinohara N., Shindoh M., Hida K.
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Journal Title
Br J Cancer
Volume: 106
Pages: 1214-1223
Related Report
Peer Reviewed
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[Journal Article] Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner2012
Author(s)
Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Shindoh M, Nonomura K, Hida K
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Journal Title
Cancer Sci
Volume: 103(6)
Issue: 6
Pages: 1038-1044
DOI
Related Report
Peer Reviewed
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[Journal Article] Biglycan is a aspecific marker and an autocrine angiogenic factor of tumour endothelial cells2012
Author(s)
Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, Onodera Y, Fujie M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K.
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Journal Title
Br J Cancer
Volume: 106(6)
Issue: 6
Pages: 1214-23
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis2012
Author(s)
Kawamoto T., Ohga N., Akiyama K., Hirata N., Kitahara S, Maishi N., Osawa T., Yamamoto K., Kondoh M., Shindoh M., Hida Y., *Hida K
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Journal Title
NAID
Related Report
Peer Reviewed
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[Patent(Industrial Property Rights)] トロポニン T と結合する DNA, これを用いた腫瘍組織における血管新生および/または脈管形成抑制剤ならびにこれを用いた細胞内へ目的物質が取り込まれることを促進する剤2012
Inventor(s)
アラナズニン, 兵藤守, 畠山浩人, 樋田京子, 大賀則孝, 原島秀吉
Industrial Property Rights Holder
アラナズニン, 兵藤守, 畠山浩人, 樋田京子, 大賀則孝, 原島秀吉
Filing Date
2012-06-21
Related Report
Overseas
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