| Project/Area Number |
23659930
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
HIDA Kyoko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIDA Yasuhiro 北海道大学, 北海道大学病院, 講師 (30399919)
OHGA Noritaka 北海道大学, 大学院・歯学研究科, 特任助教 (40548202)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 腫瘍血管 / がん / 転移 / 血管新生 |
|---|
| Research Abstract |
We have isolated two different type of TECs (HM-TEC; isolated from highly metastatic tumor, and LM-TEC; isolated from low metastatic tumor) and found they are different in many aspects. Tumor cells were more attracted and adhesive to HM-TEC in vitro assay. They migrated through the HM-TEC monolayer most among all ECs. To address the question whether TECs contribute to tumor metastasis, low metastatic tumor cells were co-xenografted with each different type of EC (HM-TEC /LM-TEC/NEC) into nude mice. These results suggested that TECs in tumor microenvironment may activelyinduce tumor metastasis.
|
