Diagnosis by microRNA in blood and saliva, and development of the new treatment method to oral cancer

Research Project

Project/Area Number	23659934
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	University of Tsukuba
Principal Investigator	BUKAWA Hiroki 筑波大学, 医学医療系, 教授 (80173558)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	口腔がん / micro RNA / 血液 / 唾液 / let-7 family / microRNA / 臨床腫瘍学
Research Abstract	Microarrays have been applied to determine the expression patterns of about 100 kinds of microRNA in the oral cancer derived cell lines, primary oral cancer tissues, blood and saliva. We have demonstrated that let-7 family was down-regulated in oral cancer derived cell lines and primary oral cancer tissues. We found the relationship to the characteristics of the expression in blood, salivaand tissue in oral cancer. In addition, we also observed microRNAs expression showing commonchanges in those.