| Project/Area Number |
23659943
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University |
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Principal Investigator |
MURATA TAKU 三重大学, 医学部附属病院, 講師 (80242965)
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| Co-Investigator(Kenkyū-buntansha) |
TAGAWA Toshio 三重大学, 医学(系)研究科(研究院), 名誉教授 (30046346)
SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 唾液腺 / 誤嚥性肺炎 |
|---|
| Research Abstract |
Causes of aspiration pneumonitis are oral bacteria et al. Saliva proteins reduce oral bacteria et al, and those expression and secretion are regulated by cAMP, and cAMP are controlled by phosphodiesterase (PDE).In rat submandibular gland main PDEs are PDE3 and PDE4. In isolated rat submandibular acini cells PDE3 was expressed, but not in duct cells. Myoepithelial cells were found in both cells. There were no change in submandibular gland of PDE3 knock out mouse. PDE4A and PDE7B were wxpressed in submandibular gland. It is suggested that each PDE regulated the expression and secretion of saliva protein.
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