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Development of new therapeutic method of aspiration pneumonitis on saliva protein promoting by PDE

Research Project

Project/Area Number 23659943
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionMie University

Principal Investigator

MURATA TAKU  三重大学, 医学部附属病院, 講師 (80242965)

Co-Investigator(Kenkyū-buntansha) TAGAWA Toshio  三重大学, 医学(系)研究科(研究院), 名誉教授 (30046346)
SHIMIZU Kasumi  三重大学, 医学部附属病院, 助教 (20378368)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords唾液腺 / 誤嚥性肺炎
Research Abstract

Causes of aspiration pneumonitis are oral bacteria et al. Saliva proteins reduce oral bacteria et al, and those expression and secretion are regulated by cAMP, and cAMP are controlled by phosphodiesterase (PDE).In rat submandibular gland main PDEs are PDE3 and PDE4. In isolated rat submandibular acini cells PDE3 was expressed, but not in duct cells. Myoepithelial cells were found in both cells. There were no change in submandibular gland of PDE3 knock out mouse. PDE4A and PDE7B were wxpressed in submandibular gland. It is suggested that each PDE regulated the expression and secretion of saliva protein.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] Expression of phosphodiesterase3 in isolated rat submandibular cells2012

    • Author(s)
      関田 素子、清水 香澄、村田 琢、田川俊郎, 他
    • Organizer
      日中歯科医学大会
    • Place of Presentation
      錦江賓館(中国・成都市)
    • Related Report
      2013 Final Research Report
  • [Presentation] EXPRESSION OF PHOSPHODIESTERASE3 IN ISOLATED RAT SUBMANDIBULAR CELLS2012

    • Author(s)
      M. Sekida, K. Shimizu, T. Murata, Y. Watanabe, J. Nomura, T. Tagawa
    • Organizer
      日中歯科医学大会
    • Place of Presentation
      中国 成都
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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