| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Boron neutron capture therapy (BNCT) is a selective radiotherapy, using 10B compounds such as boronophenylalanine (BPA) and boronocaptate sodium (BSH). Sonoporation that enables extracellular materials to enter into cells was used to increase intratumoral 10B concentration. In oral squamous cell carcinoma (SCC) cells and tumors in nude mice, the 10B concentration was increased by sonoporation and tumor growth was suppressed remarkably. This suggests that sonoporation enhances the efficiency of BPA-mediated BNCT for oral SCC.
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