Study of the delivery system of nucleic acid medicines targeting cell adhesion molecules controlling the metastasis of oral cancer
| Project/Area Number |
23659945
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
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|---|
| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 医歯薬保健学研究院, 教授 (00169153)
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|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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|---|
| Keywords | 口腔癌 / 細胞接着 / インテグリン / 浸潤 / 転移 |
|---|
| Research Abstract |
Transfection of squamous cell carcinoma (SCC) cells with a mammalian expression vector containing the cDNA for integrin alpha V in the antisense orientation reduced alpha V expression in SCC cells. Transfection with antisense oligonucleotides targeting integrin beta 8 reduced beta 8 expression in SCC cells. Suppression of integrin alpha V or beta 8 by transfection with antisense cDNA plasmid or antisense oligonucleotides led to a decrease in the proliferation and invasiveness of SCC cells. In addition, the downregulation of integrin alpha V or beta8 significantly reduced the tumorigenicity of oral SCC.
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Report
(4 results)
Research Products
(27 results)
