| Project/Area Number |
23659949
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAMURA Seiji 九州大学, 歯学研究科(研究院), 教授 (60189040)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHIDA Jun-nosuke 九州大学, 歯学研究科(研究院), 助教 (80432920)
MORIYAMA Masafumi 九州大学, 歯学研究科(研究院), 助教 (20452774)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ドライマウス / 唾液 / サイトカイン / シェーグレン症候群 |
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| Research Abstract |
Th1 and Th2 cytokines from Sjogren's syndrome (SS) patients were significantly higher than controls. Furthermore, Th2 cytokines were closely associated with strong lymphocytic accumulation in salivary glands from SS patients, while Th1 and Th17 cytokines were negatively associated. Secretory IgA (SIgA) levels were not significantly different between all patient groups and controls. Chromogranin A (CgA) levels from XND patients were significantly higher than controls.
These results suggest that the measurement of cytokines, CgA, and SIgA in saliva might be useful for the diagnosis of xerostomia and also to reveal disease status.
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