Fundamental study about the cancer-of-the-mouth stem cell andmolecular target drug under low oxygen environment

Research Project

Project/Area Number	23659950
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Nagasaki University
Principal Investigator	NARUSE Tomofumi 長崎大学, 大学病院, 助教 (70549609)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	臨床腫瘍学 / mTOR阻害薬 / リンパ節転移 / 癌幹細胞 / 低酸素 / 低酸素領域 / 分子標的治療薬
Research Abstract	By the result obtained until now, a mTOR inhibitory drug Proliferation potency control of oral squamous cell carcinoma, Also to the control of a gene which participates not only in ruining maintenance of a cancer stem cell function but in lymph node metastasis, it is effective and the possibility that the application to the cancer of the mouth of a mTOR inhibitory drug was useful as future new molecular target medical treatment was suggested.