| Project/Area Number |
23659952
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ASAHINA Izumi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30221039)
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| Co-Investigator(Kenkyū-buntansha) |
SUMITA Yoshinori 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (50456654)
OHBA Seigo 長崎大学, 大学病院, 講師 (80363456)
MINAMIZATO Tokutaro 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50529807)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔粘膜炎 / 細胞治療 / 骨髄由来細胞 / 放射線障害 / 唾液腺萎縮 / 口腔癌 / 放射線 |
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| Research Abstract |
Salivary gland atrophy or osteonecrosis are serious side effects for patients with head and neck cancer who received radiation- and/or chemo-therapy. It causes the harmful effects on the quality of life after cancer treatment. However, current clinical strategies cannot efficiently prevent the occurrence of these side effects. Therefore, effectivetherapy should be developed urgently. Recently, we have shown that cell therapy with bone marrow derived cells (BMDCs) displays the preventive effects to the radiation-induced salivary gland hypofunction. Therefore, to develop this strategy, we examined the detailed condition of cell transplantation in mouse model that has radiation-induced salivary gland atrophy and osteonecrosis. As results, both intra-grandular or intra-venous injections of BMDCs, and both young and older mouse donors were as effective in repairing irradiated salivary gland. However, though the cultured mesenchymal stem cells (MSCs) were also effective to rescue the salivary hypofunction by its injection via tail vein, the survival rate of mice was seriously decreased. Cultured MSCs seemed to cause the acute pulmonary embolism after injection.
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