Identification of cervical lymphatic drainage before and after chemoradiotherapy and detection of potential lymph node metastasis using ICG

• Project/Area Number: 23659954
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127)
• Co-Investigator(Kenkyū-buntansha): MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641) ; IWAI Toshinori 横浜市立大学, 附属病院, 助教 (00468191)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 口腔癌 / 頸部リンパ節転移 / 低侵襲手術 / リンパ流路 / センチネルリンパ節 / センチネルリンパ節生検 / 化学放射線療法 / リンパ流 / ICG

Research Abstract

We could identify cerivical lymph drainage in oral cancer patients without cervical lymph node metastasis using 3D-CT lymphography and perform preoperative mapping of sentinel lymph node. Furthermore, we could identify intraoperatively sentinel lymph node by use of indocyanine green (ICG) and HyperEye Medical System (HEMS) and establish minimally invasive sentinel lymph node biopsy with small skin incision

Research Products

• [Journal Article] Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a colour charged couple device camera for oral cancer (2013)
  • Author(s): Toshinori Iwai, Jiro Maegawa, Makoto Hirota, Iwai Tohnai
  • Journal Title: British Journal of Oral and Maxillofacial Surgery Volume: 51(2)
  • Peer Reviewed
• [Journal Article] Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a colour charged couple device camera for oral cancer (2012)
  • Author(s): Iwai T, Maegawa J, Hirota M, Tohnai I
  • Journal Title: Br J Oral Maxillofac Surg Volume: 51 Issue: 2 Pages: e26-e28
  • DOI: 10.1016/j.bjoms.2012.03.002
  • Peer Reviewed
• [Presentation] 口腔癌 N0 症例に対するインドシアニングリーンと近赤外蛍光カラーカメラシステムを用いた小切開によるセンチネルリンパ節生検 (2013)
  • Author(s): 岩井俊憲,馬場隼一,柴崎麻衣子,中島英行,小栗千里,來生 知,廣田 誠,光藤健司,藤内 祝
  • Organizer: 第31回日本口腔腫瘍学会総会・学術集会
  • Place of Presentation: 東京, 秋葉原コンベンションホール
  • Year and Date: 2013-01-24
• [Presentation] 口腔癌に対する3D-CT lymphography による術前 SLN mapping と ICGを用いた SLN biopsy (2012)
  • Author(s): 岩井俊憲,柴崎麻衣子,馬場隼一,中島英行,小栗千里,來生 知,廣田 誠,光藤健司,藤内 祝
  • Organizer: 第57回日本口腔外科学会総会
  • Place of Presentation: 神奈川,パシフィコ横浜
  • Year and Date: 2012-10-19
• [Presentation] Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a colour couple device camera for oral cancer (2012)
  • Author(s): Toshinori Iwai, Jiro Maegawa, Hideyuki Nakashima, Senri Oguri, Mitomu Kioi, Makoto Hirota, Kenji Mitsudo, Iwai Tohnai
  • Organizer: XXIth Congress of the European Association for Cranio-Maxillofacial Surgery
  • Place of Presentation: Dubrovnik, Croatia
• [Presentation] 口腔癌に対する3D-CT lymographyによる術前SLN mappingとICGを用いたSLN biopsy (2012)
  • Author(s): 岩井俊憲，柴崎麻衣子，馬場隼一，中島英行，小栗千里，來生 知，廣田 誠，光藤健司，藤内 祝
  • Organizer: 第57回日本口腔外科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県）