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Development of caries prevention of elemental-substitution type targeted magnesium

Research Project

Project/Area Number 23659960
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

FUKUMOTO Emiko  東北大学, 大学病院, 助教 (10264251)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsう蝕予防 / エナメル質 / マグネシウム
Research Abstract

Fluoride has been applied for caries prevention. Apatites included Magnesium also exist in Enamel and are easy to dissolve by acid. We developed the technique for improvement of acid resistance by replace magnesium with other chemical element.
As a result of applying thin film releasing fluoride and strontium for early caries, we observed that remineralization of early caries was promoted and the color was improved. Moreover, all forty-eight deciduous teeth applied the film did not occur the caries. From these results, the ion replace technique of enamel using fluoride and strontium is considered the pivotal method for caries prevention.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2014 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Establishment of ex vivo mucocele model using salivaly gland organ culture2014

    • Author(s)
      Hino R, Furagi M, Yamada A, Arakaki M, Saito K, Sugawara Y, Ono M, Fukumoto E, Nakamura T, Fukumoto S
    • Journal Title

      Pediatric Dental Journal

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New insight into the functions of enamel matrices in calcified tissues2014

    • Author(s)
      Fukumoto S, Nakamura T, Yamada A, Arakaki M, Saito K, Xu J, Fukumoto E, Yamada Y
    • Journal Title

      Japanease Dental Science Review

      Volume: (in press)

    • NAID

      50009117196

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation2012

    • Author(s)
      Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S
    • Journal Title

      J Biol Chem

      Volume: 287(13) Issue: 13 Pages: 10590-601

    • DOI

      10.1074/jbc.m111.285874

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells2011

    • Author(s)
      Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
    • Journal Title

      Calcif Tissue Int

      Volume: 89 Issue: 1 Pages: 65-73

    • DOI

      10.1007/s00223-011-9494-0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 新規エナメル質コート材(PRG バリアコート)のイオン徐放性による再石灰化促進について2011

    • Author(s)
      菅原優、山田亜矢、福本恵美子、相澤志津子,岩本勉、福本敏
    • Organizer
      第49回日本小児歯科学会
    • Place of Presentation
      いわて県民情報交流センターアイーナ 盛岡市
    • Year and Date
      2011-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] NF-kB 経路を介した歯の形態形成分子制御機構2011

    • Author(s)
      福本敏、岩本勉、福島秀文、山田亜矢、新垣真紀子、福本恵美子、中村卓史、自見英治郎
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館 京都市
    • Year and Date
      2011-09-23
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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