Development of caries prevention of elemental-substitution type targeted magnesium

• Project/Area Number: 23659960
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: FUKUMOTO Emiko 東北大学, 大学病院, 助教 (10264251)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: う蝕予防 / エナメル質 / マグネシウム

Research Abstract

Fluoride has been applied for caries prevention. Apatites included Magnesium also exist in Enamel and are easy to dissolve by acid. We developed the technique for improvement of acid resistance by replace magnesium with other chemical element.
As a result of applying thin film releasing fluoride and strontium for early caries, we observed that remineralization of early caries was promoted and the color was improved. Moreover, all forty-eight deciduous teeth applied the film did not occur the caries. From these results, the ion replace technique of enamel using fluoride and strontium is considered the pivotal method for caries prevention.

Research Products

• [Journal Article] Establishment of ex vivo mucocele model using salivaly gland organ culture (2014)
  • Author(s): Hino R, Furagi M, Yamada A, Arakaki M, Saito K, Sugawara Y, Ono M, Fukumoto E, Nakamura T, Fukumoto S
  • Journal Title: Pediatric Dental Journal Volume: (in press)
  • Peer Reviewed
• [Journal Article] New insight into the functions of enamel matrices in calcified tissues (2014)
  • Author(s): Fukumoto S, Nakamura T, Yamada A, Arakaki M, Saito K, Xu J, Fukumoto E, Yamada Y
  • Journal Title: Japanease Dental Science Review Volume: (in press)
  • NAID: 50009117196
  • Peer Reviewed
• [Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation (2012)
  • Author(s): Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S
  • Journal Title: J Biol Chem Volume: 287(13) Issue: 13 Pages: 10590-601
  • DOI: 10.1074/jbc.m111.285874
  • Peer Reviewed
• [Journal Article] IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
  • Journal Title: Calcif Tissue Int Volume: 89 Issue: 1 Pages: 65-73
  • DOI: 10.1007/s00223-011-9494-0
  • Peer Reviewed
• [Presentation] 新規エナメル質コート材(PRG バリアコート)のイオン徐放性による再石灰化促進について (2011)
  • Author(s): 菅原優、山田亜矢、福本恵美子、相澤志津子,岩本勉、福本敏
  • Organizer: 第49回日本小児歯科学会
  • Place of Presentation: いわて県民情報交流センターアイーナ 盛岡市
  • Year and Date: 2011-11-29
• [Presentation] NF-kB 経路を介した歯の形態形成分子制御機構 (2011)
  • Author(s): 福本敏、岩本勉、福島秀文、山田亜矢、新垣真紀子、福本恵美子、中村卓史、自見英治郎
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館 京都市
  • Year and Date: 2011-09-23