| Project/Area Number |
23659963
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MORIYAMA Keiji 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20262206)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMOTO Tatsuo 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (50323704)
KOBAYASHI Yukiho 東京医科歯科大学, 硬組織疾患ゲノムセンター, 特任助教 (20596233)
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| Research Collaborator |
DUARTE Carolina 東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リラキシン / リラキシンレセプター / 磁性リポソーム / 顎顔面頭蓋発生 / 骨代謝 / リポソーム / 骨芽細胞 / 骨縫合部 / ナノテクノロジー / 磁気制御 / 破骨細胞 |
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| Research Abstract |
Relaxin is a pleiotropic hormone of the insulin like peptide hormonefamily.Rxfp1, Rxfp2 mRNA were expressed intensely in the developing mouse (E13.5~17.5)brain, bone, tongue muscle, dental lamina, tooth primordia. This finding indicated thatRelaxin and its receptor play an important role in the craniofacial development.Additionally, we determined the effect of Relaxin on the phenotypes of osteoblasts. Fromthe results of siRNA targeting experiments, Rxfp2 was probed to play important roles indifferentiation, mineralization, and matrix metabolism of the osteoblasts.
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