Development of new technology for controlling suture remodeling using magnetized liposome with liposome

• Project/Area Number: 23659963
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MORIYAMA Keiji 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20262206)
• Co-Investigator(Kenkyū-buntansha): KAWAMOTO Tatsuo 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (50323704) ; KOBAYASHI Yukiho 東京医科歯科大学, 硬組織疾患ゲノムセンター, 特任助教 (20596233)
• Research Collaborator: DUARTE Carolina 東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: リラキシン / リラキシンレセプター / 磁性リポソーム / 顎顔面頭蓋発生 / 骨代謝 / リポソーム / 骨芽細胞 / 骨縫合部 / ナノテクノロジー / 磁気制御 / 破骨細胞

Research Abstract

Relaxin is a pleiotropic hormone of the insulin like peptide hormonefamily.Rxfp1, Rxfp2 mRNA were expressed intensely in the developing mouse (E13.5~17.5)brain, bone, tongue muscle, dental lamina, tooth primordia. This finding indicated thatRelaxin and its receptor play an important role in the craniofacial development.Additionally, we determined the effect of Relaxin on the phenotypes of osteoblasts. Fromthe results of siRNA targeting experiments, Rxfp2 was probed to play important roles indifferentiation, mineralization, and matrix metabolism of the osteoblasts.

Research Products

• [Journal Article] Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development (2012)
  • Author(s): Tsuji-Takechi K, Negishi-Koga T, Sumiya E, Kukita A, Kato S, Maeda T, Pandolfi PP, Moriyama K, Takayanagi H
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Issue: 7 Pages: 2561-6
  • DOI: 10.1073/pnas.1116042109
  • Peer Reviewed
• [Journal Article] Deletion at chromosome 10p11.23-p12.1 defines characteristic phenotypes with marked midface retrusion (2012)
  • Author(s): Okamoto N, Hayashi S, Masui A, Kosaki R, Oguri I, Hasegawa T, Imoto I, Makita Y, Hata A, Moriyama K, Inazawa J
  • Journal Title: J Hum Genet Volume: 57(3) Issue: 3 Pages: 191-196
  • DOI: 10.1038/jhg.2011.154
  • Peer Reviewed
• [Journal Article] Accuracy of orthodontic miniscrew implantation guided by stereolithographic surgical stent based on cone-beam CT-derived 3D images (2012)
  • Author(s): Qiu L, Haruyama N, Suzuki S, Yamada D, Obayashi N, Kurabayashi T, Moriyama K
  • Journal Title: Angle Orthod Volume: 82 Issue: 2 Pages: 284-93
  • DOI: 10.2319/033111-231.1
  • Peer Reviewed
• [Journal Article] Prevalence and gender comparison of malocclusion among Japanese adolescents: A population-based study. (2012)
  • Author(s): Komazaki Y, Fujiwara T, Ogawa T, Sato M, Suzuki K, Yamagata Z, Moriyama K.
  • Journal Title: J World Fed Orthod Volume: 1 Pages: 67-72
• [Journal Article] Orthognathic treatment for a patient with facial asymmetry associated with unilateral scissors-bite and a collapsed mandibular arch (2012)
  • Author(s): Suda N., et.al.
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: 141 Issue: 1 Pages: 94-104
  • DOI: 10.1016/j.ajodo.2010.02.042
  • Peer Reviewed
• [Journal Article] Differential articulatory movements during Japanese /s/ and /t/ as revealed by MR image sequences with tooth visualization (2012)
  • Author(s): Ng IW, et al
  • Journal Title: Arch Oral Biol Volume: (In press) Issue: 6 Pages: 749-59
  • DOI: 10.1016/j.archoralbio.2011.11.002
  • Peer Reviewed
• [Journal Article] Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2). (2012)
  • Author(s): Tanimoto Y., et al.
  • Journal Title: J Biol Chem. Volume: 287 Issue: 25 Pages: 21429-38
  • DOI: 10.1074/jbc.m112.362145
  • Peer Reviewed
• [Journal Article] Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture. (2012)
  • Author(s): Veistinen L, Takatalo M, Tanimoto Y, Kesper DA, Vortkamp A, Rice DP.
  • Journal Title: Front Physiol. Volume: 3 Pages: 121-121
  • DOI: 10.3389/fphys.2012.00121
• [Journal Article] Dental and maxillofacial characteristics in six Japanese individuals with ectrodactyly-ectodermal dysplasia-clefting(EEC) syndrome (2012)
  • Author(s): Okamura E, Suda N, Baba Y, Fukuoka H, Ogawa T, Ohkuma M, Ahiko N, Yasue A, Tengan T, Shiga M, Tsuji M, Moriyama K
  • Journal Title: Cleft Palate Craniofac J Volume: (印刷中) Issue: 2 Pages: 192-200
  • DOI: 10.1597/11-123
  • Peer Reviewed
• [Journal Article] ADAMTSL6ss rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly (2011)
  • Author(s): Saito M, Kurokawa M, Oda M, Oshima M, Tsutsui K, Kosaka K, Nakao K, Ogawa M, Manabe RI, Suda N, Ganjargal G, Hada Y, Noguchi T, Teranaka T, Sekiguchi K, Yoneda T, Tsuji T
  • Journal Title: J Biol Chem Volume: 286 Issue: 9 Pages: 38602-13
  • DOI: 10.1002/jcp.24021
  • Peer Reviewed
• [Journal Article] Systemic and maxillofacial characteristics of individuals affected by Beckwith-Wiedemann syndrome who have not received a glossectomy (2011)
  • Author(s): Kawafuji A, Suda N, Suzuki T, Ichikawa N, Kakara S, Baba Y, Ogawa T, Tsuji M, Moriyama K
  • Journal Title: Am J Orthod Dentfacial Orthop Volume: 139 Issue: 4 Pages: 517-25
  • DOI: 10.1016/j.ajodo.2009.07.021
  • Peer Reviewed
• [Journal Article] Application of MRI movie for observation of articulatory movement during africative /s/ and a plosive /t/ (2011)
  • Author(s): Ng IW, et al
  • Journal Title: Angle Orthod Volume: 81 Issue: 2 Pages: 237-244
  • DOI: 10.2319/060210-301.1
  • Peer Reviewed
• [Journal Article] Familial Non-syndromic Oligodontia with a Novel Frame Shift Mutation of PAX9 is Related to Impaired RNA Stability (2011)
  • Author(s): Suda N, Ogawa T, Kojima T, Saito C, Moriyama K
  • Journal Title: J Dent Res Volume: 90 Issue: 3 Pages: 382-6
  • DOI: 10.1177/0022034510390042
  • Peer Reviewed
• [Journal Article] Association between intraoral pressure and molar position and inclination in subjects with facial asymmetry (2011)
  • Author(s): Jun-ichi Takada
  • Journal Title: European Journal of Orthodontics Volume: 33 Issue: 3 Pages: 243-249
  • DOI: 10.1093/ejo/cjq060
  • Peer Reviewed
• [Journal Article] Long-term stability of LeFort III distraction osteogenesis with a rigid external distraction device in a patient with Crouzon syndrome (2011)
  • Author(s): Kuroda S., et.al.
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: 140 Issue: 4 Pages: 550-561
  • DOI: 10.1016/j.ajodo.2009.12.038
  • Peer Reviewed
• [Presentation] Expression Pattern of Relaxin Receptors During Mouse Craniofacial Development (2012)
  • Author(s): Duarte C, Kobayashi Y, Kawamoto T, Moriyama K.
  • Organizer: 90th General Session & Exhibition of the IADR
  • Place of Presentation: Foz do Iguacu,Brazil
• [Presentation] マウス頭蓋顎顔面領域の発生過程におけるリラクシン受容体遺伝子発現様相の解析 (2012)
  • Author(s): ドゥアルテ カロリーナ,小林起穂,川元龍夫,森山啓司
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Presentation] Expression Pattern of Relaxin Receptors During Mouse Craniofacial Development. (2012)
  • Author(s): Duarte C, Kobayashi Y, Kawamoto T, Moriyama K.
  • Organizer: 90th General Session & Exhibition of the IADR
  • Place of Presentation: イグアス、ブラジル
• [Presentation] New biological insights of tooth movement in response to mechanical stress. (2011)
  • Author(s): Moriyama K
  • Organizer: The 23rd annual conference of the Taiwan Association of Orthodontists(招待講演)
  • Place of Presentation: Taichung, Taiwan
• [Presentation] "An orthodontic perspective of long-term care for cleft patients" (2011)
  • Author(s): Moriyama K
  • Organizer: The 15th Congress of Korean Cleft Lip and Palate Association (KCLPA 2011)(招待講演)
  • Place of Presentation: Seoul
• [Presentation] "Some considerations on dentofacial growth in cleft patients" (2011)
  • Author(s): Moriyama K
  • Organizer: The 15th Congress of Korean Cleft Lip and Palate Association (KCLPA 2011)(招待講演)
  • Place of Presentation: Seoul
• [Presentation] "Growth and Development of Cleft Patients" (2011)
  • Author(s): Moriyama K
  • Organizer: The 15th Congress of Korean Cleft Lip and Palate Association (KCLPA 2011)(招待講演)
  • Place of Presentation: Seoul
• [Presentation] Osteocyte is a key modulator for orthodontic tooth movement induced by mechanical stress.
  • Author(s): Keiji Moriyama
  • Organizer: The 112th American Association of Orthodontists
  • Place of Presentation: ホノルル、アメリカ
  • Invited
• [Presentation] Outcome and stability of surgical orthodontic treatment for mandibular prognathism with open bite.
  • Author(s): Keiji Moriyama
  • Organizer: The 14th International Symposium on Dentofacial Development and Function.
  • Place of Presentation: 北京、中国
  • Invited
• [Presentation] Outcome and stability of surgical treatment for mandibular prognathism with long face.
  • Author(s): Keiji Moriyama:
  • Organizer: The 8th Asian Pacific Orthodontic Conference
  • Place of Presentation: ニューデリー、インド
  • Invited
• [Book] Moriyama K. Atlas of orthodontictreatment for patients with birth defect. (2012)
  • Author(s): Kuroda T, Ohyama K, Motohashi N
  • Publisher: Needham Press
• [Book] Clinical correlate: cleidocranial dysplasia. (2012)
  • Author(s): Takeda S, Haga N, Moriyama K.
  • Publisher: WILEY-BLACKWELL
• [Book] Atlas of orthodontic treatment for patients with birth defect. (2012)
  • Author(s): Kuroda T., et al.
  • Total Pages: 207
  • Publisher: Needham Press
• [Book] Mineralized tissues in oral and craniofacial science (2012)
  • Author(s): McCauley LK., et al.
  • Total Pages: 370
  • Publisher: WILEY-BLACKWELL
• [Remarks]
  • URL: http://www.tmd.ac.jp/grad/mort/mort-J.htm
• [Remarks] 骨との結合が3倍速くなるコーティング法を開発 矯正歯科用骨膜下デバイスなどで患者の負担軽減を目指す
  • URL: http://www.nims.go.jp/news/press/2013/04/p201304080.html
• [Patent(Industrial Property Rights)] HAp/Col複合体によって被覆された生体材料 (2012)
  • Inventor(s): 菊池正紀、高久田和夫、森山啓司、鈴木聖一、上園将慶
  • Industrial Property Rights Holder: 菊池正紀、高久田和夫、森山啓司、鈴木聖一、上園将慶
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-096056
  • Filing Date: 2012-04-19