| Project/Area Number |
23659967
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZA Haruyoshi 九州大学, 歯学研究院, 講師 (30336151)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 小児歯科学 / 乳歯 / 幹細胞 / アンチエイジング |
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| Research Abstract |
We isolated mesenchymal stem cells from human exfoliated deciduous teeth (SHED). SHED owned stem cell properties including clonogenicity, self-renew, stem cell marker expression, multipotency, in vivo tissue regenerative capacity and in vitro immunomodulatory function. To examine the therapeutic efficacy of SHED on immune diseases, SHED were intravenously transplanted into systemic lupus erythematosus (SLE) model MRL/lpr mice. Systemic SHED transplantation improved SLE-like disorders including short lifespan, elevated autoantibody levels and nephritis-like renal dysfunction. SHED transplantation was also able to recover osteoporosis bone reduction in long bones of MRL/lpr mice. Furthermore, SHED -mediated tissue engineering induced bone regeneration in critical calvarial bone-defect sites of immunocompromised mice. These data suggest SHED is source of the stem cell-based immune therapy and tissue engineering in regenerative medicine
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