Hematopoietic cells regulate bone metabolism
| Project/Area Number |
23659972
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Toshihide 松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯科矯正学 / 破骨細胞 / Wnt / 関節炎 / 脂肪細胞 / 骨髄 / Wnt5a / Sfrp5 |
|---|
| Research Abstract |
Adipose tissues in bone marrow are increased with aging. We therefore explored effects of adipose tissues in bone marrow on bone formation and resorption. The expressionof Wnt5a, which promotes osteoclast formation, was increased in arthritis model mice.The expression of Sfrp5, an inhibitor of Wnt5a, was decreased. Treatment with Sfrp5 inhibited the stimulatory effect of Wnt5a on osteoclast formation. Adipose tissues highly expressed Sfrp5. Enforced expression of Sfrp5 in arthritis mice abrogated bone destruction associated with arthritis.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts2012
Author(s)
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
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Journal Title
Advanced Materials
Volume: 24
Issue: 16
Pages: 2176-2185
DOI
Related Report
Peer Reviewed
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[Journal Article] Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.2012
Author(s)
Harada S, Mizoguchi T, Kobayashi Y, Nakamichi Y, Takeda S, Sakai S, Takahashi F, Saito H, Yasuda H, Udagawa N, Suda T, Takahashi N.
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Journal Title
J Bone Miner Res
Volume: 27
Pages: 461-473
Related Report
Peer Reviewed
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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