Research Project
Grant-in-Aid for Challenging Exploratory Research
Adipose tissues in bone marrow are increased with aging. We therefore explored effects of adipose tissues in bone marrow on bone formation and resorption. The expressionof Wnt5a, which promotes osteoclast formation, was increased in arthritis model mice.The expression of Sfrp5, an inhibitor of Wnt5a, was decreased. Treatment with Sfrp5 inhibited the stimulatory effect of Wnt5a on osteoclast formation. Adipose tissues highly expressed Sfrp5. Enforced expression of Sfrp5 in arthritis mice abrogated bone destruction associated with arthritis.
All 2013 2012 Other
All Journal Article (16 results) (of which Peer Reviewed: 11 results, Open Access: 2 results) Presentation (7 results) (of which Invited: 3 results)
Endocrinology
Volume: 190 Issue: 2 Pages: 773-782
10.1210/en.2012-1928
J Mol Med (Berl)
Volume: 91 Issue: 1 Pages: 15-23
10.1007/s00109-012-0974-0
Proc Natl Acad Sci USA
Volume: 109 Issue: 25 Pages: 10006-10011
10.1073/pnas.1207361109
J Cell Sci
Volume: 125 Pages: 2910-2917
Advanced Materials
Volume: 24 Issue: 16 Pages: 2176-2185
10.1002/adma.201103832
Nat Med
Volume: 18 Pages: 405-412
J Immunol
Volume: 188 Issue: 4 Pages: 1772-1781
10.4049/jimmunol.1101174
J Bone Miner Res
Volume: 27 Pages: 461-473
TheBone
Volume: 26 Pages: 151-159
実験医学
Volume: 30 Pages: 1933-1936
日本抗加齢医学会雑誌
Volume: 8 Pages: 719-725
ケミカルエンジニアリング
Volume: 57 Pages: 921-925
Clinical Calcium.
Volume: 22 Pages: 1701-1706
Journal of Molecular Medicine
Volume: 91 Pages: 15-23
Nat.Med.
Volume: (印刷中) Issue: 3 Pages: 405-12
10.1038/nm.2653
Volume: 27 Issue: 2 Pages: 461-473
10.1002/jbmr.555