| Project/Area Number |
23659974
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|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Periodontal dentistry
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|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Tomoyuki 新潟大学, 医歯学総合病院, 医員 (30447635)
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|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周免疫機能学 / 歯周炎 / 小胞体ストレス / 加齢 / マウス実験的歯周炎 / porphyromonas gingivalis / BiP / ATF-4 / CHOP / XBP-1 |
|---|
| Research Abstract |
Endoplasmic reticulum stress was induced in gingival tissue of orally periodontopathic bacterium infected mice. Administration of chemical chaperone,4-phenylbutyric acid, significantly inhibited alveolar bone resorption in the infected mice. In addition, 4-phenylbutyric acid inhibited osteoclastogenesis in vitro. Our findings suggest that endoplasmic reticulum stress involves osteoclastogenesis during alveolar bone resorption in the progression of periodontal disease.
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