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Establishment of screening system for novel therapeutics for periodontal disease by using low molecule compound

Research Project

Project/Area Number 23659980
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionTokyo University of Science

Principal Investigator

SAITO Masahiro  東京理科大学, 基礎工学部, 准教授 (40215562)

Co-Investigator(Kenkyū-buntansha) TSUJI Takashi  東京理科大学, 総合研究機構, 准教授 (50339131)
YAMADA Satoru  大阪大学, 大学院・歯学研究科 (40359849)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯周免疫機能学 / 再生 / 歯根膜 / マイクロフィブリル / 創傷治癒誘導 / 低分子化合物 / 弾性線維 / 結合組織 / マルファン病症候群 / 創薬開発 / 弾性繊維 / マルファン病
Research Abstract

We have shown that regeneration of periodontal tissue is required for reorganization of microfibril. To develop a novel therapeutics for periodontal disease, we attempt to develop low molecular compoundto stimulate expression of ADAMTSL6・in which promotion of microfibril assembly. To achieve these purposes, we demonstrated that generation of cell possessing EGFP reporter under control by ADAMTSL6・promoter.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2013 2012 2011 2005 Other

All Journal Article (14 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Dpysl4 is involved in tooth germ morphogenesis through growth regulation, polarization and differentiation of dental epithelial cells.2013

    • Author(s)
      Yasukawa M, Ishida K, Yuge Y,Hanaoka M, Minami Y, Ogawa M, Sasaki T, Saito M, Tsuji T
    • Journal Title

      Int J Biol Sci

      Volume: 9(4) Pages: 382-90

    • Related Report
      2012 Final Research Report
  • [Journal Article] Roles of Heparan Sulfate Sulfation in Dentinogenesis2012

    • Author(s)
      Hayano, S., Kurosaka, H., Yanagita, T., Kalus , I. , Milz, F., Ishihara, Y., Nurul, Islam, M., Kawanabe, N., Saito, M.,Kamioki, H., Adachi, T., Dierks, T. and Yamashiro, T.*
    • Journal Title

      J Biol Chem

      Volume: 287(15) Pages: 12217-12229

    • Related Report
      2012 Final Research Report
  • [Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation.2012

    • Author(s)
      Arakaki, M., Ishikawa, M., Nakamura, T., Iwamoto, T., Yamada, A., Fukumoto, E., Saito, M., Otsu, K., Harada, H., Yamada, Y. and Fukumoto, S.*
    • Journal Title

      J Biol Chem

      Volume: 287(13) Pages: 10590-1060

    • Related Report
      2012 Final Research Report
  • [Journal Article] Roles of Heparan Sulfate Sulfation in Dentinogenesis2012

    • Author(s)
      Hayano S, Kurosaka H, Yanagita T, Kalus I, Milz F, Ishihara Y, et al
    • Journal Title

      J Biol Chem

      Volume: (印刷中) Issue: 15 Pages: 12217-12229

    • DOI

      10.1074/jbc.m111.332924

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation2012

    • Author(s)
      Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S
    • Journal Title

      J Biol Chem

      Volume: 287(13) Issue: 13 Pages: 10590-601

    • DOI

      10.1074/jbc.m111.285874

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular matrix administration as a potential therapeutic strategy for periodontal ligament regeneration2012

    • Author(s)
      M.Saito and T.Tsuji
    • Journal Title

      Expert Opin Biol Ther

      Volume: 12(3) Issue: 3 Pages: 299-309

    • DOI

      10.1517/14712598.2012.655267

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ADAMTSL6Lβrescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.2011

    • Author(s)
      Saito, M.,*Kurokawa, M., Oda, M., Oshima, M., Tsutsui, K., Kosaka, K., Nakao, K., Ogawa, M., Manabe, R., Suda, N., Ganjargal, G., Hada, Y., Noguchi, T., Teranaka, T., Sekiguchi, K., Yoneda, T. and Tsuji, T
    • Journal Title

      J Biol Chem

      Volume: 286(44) Pages: 38602-38613

    • Related Report
      2012 Final Research Report
  • [Journal Article] Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy2011

    • Author(s)
      M.Oshima, et al
    • Journal Title

      PLoS ONE

      Volume: 6(7) Issue: 7 Pages: 10590-10601

    • DOI

      10.1371/journal.pone.0021531

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of enamel matrix protein expression in an ameloblast cell line co-cultured with a mesenchymal cell line in vitro.2011

    • Author(s)
      Matsumoto, A., Harada, H., Saito, M. and Taniguchi, A.*
    • Journal Title

      In Vitro Cell Dev Biol Anim

      Volume: 47(1) Pages: 39-44

    • Related Report
      2012 Final Research Report
  • [Journal Article] ADAMTSL6&β rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly2011

    • Author(s)
      M.Saito et, al
    • Journal Title

      J Biol Chem

      Volume: 286(44) Issue: 44 Pages: 38602-38613

    • DOI

      10.1074/jbc.m111.243451

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of immortalized mouse dental follicle cell2005

    • Author(s)
      Yokoi, T., Saito, M.,* Nishida, E., Kosaka, K, Tsubakimoto, T. and Teranaka, T
    • Journal Title

      Bull Kanagawa Dent Col

      Volume: 33(1) Pages: 136-140

    • Related Report
      2012 Final Research Report
  • [Journal Article] Molecular mechanisms of Periodontal development, and its prospect of regenerative medicine for periodontium2005

    • Author(s)
      Saito, M.,* Tsunoda, A., Yokoi, T., Hattori, S., Tsubakimoto, T., Nishida, E., Kousaka, K., Toyoda, M., Sato, S., Noguchi, T. and Teranaka, T
    • Journal Title

      Bull Kanagawa Dent Col

      Volume: 33(1) Pages: 31-35

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immortalization of cementoblast progenitor cells with Bmi-1 and TERT.2005

    • Author(s)
      Saito, M.,* Handa, K., Kiyono, T., Hattori, S., Yokoi, T., Tsubakimoto, T., Harada, H., Noguchi, T., Toyoda, M., Sato, S. and Teranaka, T
    • Journal Title

      J Bone Miner Res

      Volume: 20(1) Pages: 50-57

    • Related Report
      2012 Final Research Report
  • [Journal Article] Alveolar Bone Marrow as a Cell Source for Regenerative Medicine: Differences between Alveolar and Iliac Bone Marrow Stromal Cells2005

    • Author(s)
      Matsubara, T., Suardita, K., Ishii, M., Sugiyama, M., Igarashi, A., Oda, R., Nishimura, M., Saito, M., Nakagawa, K., Yamanaka, K., Miyazaki, K., Shimizu, M., Tsuji, K., Nakamura, K. and Kato, Y.*
    • Journal Title

      J Bone Miner Res

      Volume: 20(3) Pages: 399-409

    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞外マトリックス補充療法による新規歯周病治療技術の開発2012

    • Author(s)
      齋藤正寛
    • Organizer
      第12回日本外傷歯学会総会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 細胞外マトリックス補充療法による新規歯周病治療技術の開発2012

    • Author(s)
      齋藤正寛
    • Organizer
      第6回日本再生歯科医学会シンポジウム
    • Place of Presentation
      帯広
    • Year and Date
      2012-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Forefront of periodontal regeneration therapy2011

    • Author(s)
      Saito,M.and Tsuji,T
    • Organizer
      ISBB meeting Taipei
    • Place of Presentation
      Taiwan
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗加齢医学における歯の再生の役割2011

    • Author(s)
      齋藤正寛、辻 孝
    • Organizer
      第11回抗加齢学会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Forefront of periodontal regeneration therapy2011

    • Author(s)
      Masahiro Saito
    • Organizer
      ISBB
    • Place of Presentation
      Taipei
    • Related Report
      2011 Research-status Report
  • [Presentation] ADAMTSL6βによるTGF-βシグナル抑制効果に関する研究2011

    • Author(s)
      黒河みさ紀、荻野光明、大島正充、辻 孝、齋藤正寛
    • Organizer
      第135回日本保存学会秋期学術大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] Present State and Progression of Periodontal Regeneration Therapy

    • Author(s)
      Masahiro Saito
    • Organizer
      IADR general session
    • Place of Presentation
      Seattle USA
    • Related Report
      2012 Annual Research Report
  • [Book] "Tooth regeneration therapy" as a next generation of regenerative medicine., Hiromasa Yoshie, At the forefront. Illustrated Topics in dental research and clinical practice2012

    • Author(s)
      M.Saito.,and T. Tsuji
    • Publisher
      Quintessence Publishing Co, Inc., Hanover Park
    • Related Report
      2012 Final Research Report
  • [Book] AT THE FOREFRONT ILLUSTRATED TOPICS IN DENTAL RESEARCH AND CLINICAL PRACTICE2012

    • Author(s)
      Saito, M
    • Total Pages
      108
    • Publisher
      Quintessence. Publishing Co, Inc
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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