| Project/Area Number |
23659984
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NAGATA Hideki 大阪大学, 歯学研究科(研究院), 准教授 (50260641)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OJIMA Miki 大阪大学, 歯学研究科(研究院), 助教 (20263303)
MAEDA Kazuhiko 大阪大学, 歯学研究科(研究院), 助教 (00346165)
TANAKA Muneo 大阪大学, 歯学部附属病院, 講師 (90263300)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 歯周病細菌 / 口腔常在菌 / 病原因子 / バイオフィルム |
|---|
| Research Abstract |
Interaction with oral predominant bacteria plays an important role in colonization of periodontopathic bacteria. Culture supernatant of Streptococcus oralis repressed growth of Porphyromonas gingivalis. S. oralisglyceraldehydes-3-phosphate dehydrogenase (GAPDH), which binds P. gingivalisfimbriae, affected expression of P. gingivalis gene related to biofilm formation.
|
