Interactionbetween salivary proteins andoral bacteria: determinants for bacterial adherence and aggregation

• Project/Area Number: 23659987
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Kagoshima University
• Principal Investigator: OHO Takahiko 鹿児島大学, 大学院・医歯学総合研究科, 教授 (50160940)
• Co-Investigator(Kenkyū-buntansha): NAGATA Emi 鹿児島大学, 医学部・歯学部附属病院, 助教 (00304816)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 歯学 / 細菌 / 唾液

Research Abstract

Bacterial aggregation in saliva is advantageous for oral health since bacteria are swallowed before adhering to oral tissues. The purpose of this study was to investigate mechanisms by which bacterial adherence to saliva-coated enamel surfaces or saliva-induced bacterial aggregation occur. The results indicate that SRCRP5 region in salivary agglutinin is useful for the clearance of Streptococcus mutans

Research Products

• [Journal Article] Staphylococcus aureus SasA is responsible for binding to salivary agglutinin, gp340 (2013)
  • Author(s): Kukita Kenji
  • Journal Title: Infection and Immunity Volume: in press
  • Peer Reviewed
• [Journal Article] Effect of saliva viscosity on the coaggregation between oral streptococci and Actinomyces naeslundii (2012)
  • Author(s): Kitada, K., and Oho, T.
  • Journal Title: Effect of saliva viscosity on the coaggregation between oral streptococci and Actinomyces naeslundii Volume: 29
• [Journal Article] Effect of saliva viscosity on the coaggregation between oral streptococci and Actinomyces naeslundii (2012)
  • Author(s): Kitada, K., and Oho, T.
  • Journal Title: Gerodontology Volume: in press Issue: 2
  • DOI: 10.1111/j.1741-2358.2011.00595.x
  • Peer Reviewed
• [Journal Article] Staphylococcus aureusSasA is responsible for binding to salivary agglutinin, gp340, derived from human saliva
  • Author(s): Kukita, K., Kawada-Matsuo, M., Oho, T., Nagatomo, M., Oogai, Y., Hashimoto, M., Suda, Y., Tanaka, T., and Komatsuzawa, H.
  • Journal Title: Staphylococcus aureusSasA is responsible for binding to salivary agglutinin, gp340, derived from human saliva Volume: (in press)
• [Presentation] Staphylococcus aureusSasA is responsible for the binding to salivary agglutinin, gp340 (2013)
  • Author(s): 久木田 賢司、松尾 美樹、小松澤 均、於保 孝彦、隅田 泰生、橋本 雅仁
  • Organizer: 第86回日本細菌学会
  • Place of Presentation: 千葉
  • Year and Date: 2013-03-18
• [Presentation] Fusobacterium nucleatumの唾液アミラーゼへの付着機構の解析 (2012)
  • Author(s): Zulfiqar Maria、山口 泰平、佐藤 節子、於保 孝彦
  • Organizer: 第34回九州口腔衛生学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2012-10-17
• [Presentation] Fusobacterium nucleatumの唾液アミラーゼへの付着機構の解析
  • Author(s): Zulfiqar Maria
  • Organizer: 第34回九州口腔衛生学会
  • Place of Presentation: 鹿児島市
• [Presentation] Staphylococcus aureus SasA is responsible for the binding to salivary agglutinin, gp340
  • Author(s): 久木田 賢司
  • Organizer: 第86回日本細菌学会
  • Place of Presentation: 千葉市
• [Remarks]
  • URL: http://www.hal.kagoshima-u.ac.jp/dental/Predent/index.html