Innovative research on pathophysiology of dysphagia in Dementia: Investigation of association between primitive reflexes and brain activity, and development of therapy

• Project/Area Number: 23659991
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: HAMURA Akira 日本歯科大学, 生命歯学部, 教授 (60162921)
• Co-Investigator(Kenkyū-buntansha): KIKUTANI Takrshi 日本歯科大学, 生命歯学部, 教授 (20214744)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 歯学 / 社会系歯学 / 老年歯学 / 社会歯学 / 老年歯科学

Research Abstract

In 2011 study, there was a significantly relationship between feeding/swallowing function and risk of oral care, and primitive reflexes. In 2012 study, sight and verbal information improved the cognition in the healthy adults. In 2013 study, verbal information improved the brain activation regardless of sight in healthy elderly people. Moreover in elderly dementia patients, influence from outside improved the brain activation.
The results of these studies showed that sight and verbal information made differences for the brain activation. It has been suggested that changing way to feeding and surrounding of eating is important for food intake in safety.

Research Products

• [Journal Article] Effects of the reappearance of primitive reflexes on eating function and prognosis. (2014)
  • Author(s): Hobo K, Kawase J, Tamura F, Groher M, Kikutani T, Sunakawa H.
  • Journal Title: Geriatr Gerontol Int. Volume: 14(1) Issue: 1 Pages: 190-197
  • DOI: 10.1111/ggi.12078
  • Peer Reviewed
• [Journal Article] Interrelationship of oral health status, swallowing function, nutritional status, and cognitive ability with activities of daily living in Japanese elderly people receiving home care services due to physical disabilities (2013)
  • Author(s): Furuta M, Komiya-Nonaka M, Akifusa S, Shimazaki Y, Adachi M, Kinoshita T, Kikutani T, Yamashita Y
  • Journal Title: Community Dent Oral Epidemiol Volume: 41(2) Issue: 2 Pages: 173-181
  • DOI: 10.1111/cdoe.12000
  • Peer Reviewed
• [Presentation] Effect of cognition during anticipatory stage on brain activation (2012)
  • Author(s): Genkai S, Tamura F, Kikutani T, Kawase J, Hamura A, Yaegaki K
  • Organizer: 60th Annual Meeting of the Japanese Association for Dental Research, Program and abstracts of papers
  • Place of Presentation: 新潟国際会議場
• [Presentation] 先行期の食物認知が脳の活性に与える影響 (2012)
  • Author(s): 元開早絵,川瀬順子,田村文誉,須田牧夫,菊谷武,羽村章
  • Organizer: 第29回日本障害者歯科学会総会および学術大会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 先行期の食物認知が脳活性に与える影響
  • Author(s): 元開早絵, 川瀬順子, 田村文誉, 須田牧夫, 羽村章, 菊谷武
  • Organizer: 第29回日本障害者歯科学会総会および学術大会
  • Place of Presentation: 北海道(札幌コンベンションセンター)
• [Presentation] Effects of Cognition During Anticupatory Stage on Brain Activation
  • Author(s): Genkai S, Tamura F, Kikutani T, Kawase J, Hamura A, Yaegaki K
  • Organizer: 60th Annual Meeting of the Japanese Association for Dental Research, Program and abstracts of papers
  • Place of Presentation: 新潟(新潟コンベンションセンター)