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Search for relevance and the mechanism of antioxidant system and the activation of system of cognitive brain function in the elderly by function therapy of eating and swallowing

Research Project

Project/Area Number 23660047
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Clinical nursing
Research InstitutionKanagawa Dental College

Principal Investigator

LEE Masaichi  神奈川歯科大学, 歯学研究科(研究院), 教授 (60220795)

Co-Investigator(Kenkyū-buntansha) ONOZUKA Minoru  神奈川歯科大学, 歯学部, 名誉教授 (90084780)
KOMATSU Tomoko  神奈川歯科大学, 歯学部, 講師 (20234875)
Co-Investigator(Renkei-kenkyūsha) KANEMATSU Masayuki  岐阜大学, 医学部付属病院, 准教授 (40252134)
ONO Yumie  明治大学, 理工学部, 准教授 (10360207)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords嚥下体操 / 唾液 / 抗酸化能 / 活性酸素種 / 酸化ストレス / 筋電図 / 電子スピン共鳴法 / 咀嚼筋 / 摂食嚥下体操 / fMRI / 光トポグラフィー / ESR / 光トポグラフィ
Research Abstract

We purposed that cognitive enhancement in the elderly by swallowing exercises, which was s eating and swallowing function training, would be essential on the mechanism due to oxidative stress using original developed-electromyography (EMG) and electron spin resonance (ESR). As a result of using the EMG, both young and the elderly may facilitate the muscle activity of swallowing-related muscle during performing swallowing exercises By performing swallowing exercises, it was also observed the enhancement of antioxidant system. From these results, swallowing exercises may prevent for aspiration pneumonia induced by Dysphagia, which is caused by cerebral vascular diseases due to oxidative stress.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (79 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 22 results,  Open Access: 3 results) Presentation (43 results) (of which Invited: 2 results) Book (10 results) Remarks (3 results)

  • [Journal Article] Passive ultrasonic irrigation in the presence of a low concentration of hydrogen peroxide enhances hydroxyl radical generation and bactericidal effect against <i>Enterococcus faecalis </i>2014

    • Author(s)
      Kobayashi Y, Hayashi M, Yoshino F, Tamura M, Yoshida A, Ibi H, Lee M-C, Ochiai K, Ogiso B
    • Journal Title

      Journal of Oral Science

      Volume: 56 Issue: 1 Pages: 35-39

    • DOI

      10.2334/josnusd.56.35

    • NAID

      130003393076

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bactericidal effect of hydroxyl radicals generated from a low concentration hydrogen peroxide with ultrasound in endodontic treatment2014

    • Author(s)
      Y. Kobayashi, M. Hayashi, F. Yoshino, M. Tamura, A. Yoshida, H. Ibi, MC. Lee, K. Ochiai and B. Ogiso
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 3 Pages: 161-165

    • DOI

      10.3164/jcbn.13-86

    • NAID

      130004466753

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of the redoxstate with reactive oxygen species for 5-fluorouracil- induced oral mucositis in hamsters2013

    • Author(s)
      Yoshino F, Yoshida A, Nakajima A, Wada-Takahashi S, Takahashi S-S, Lee M-C
    • Journal Title

      PLoS ONE

      Volume: 8(12) Issue: 12 Pages: 1-6

    • DOI

      10.1371/journal.pone.0082834

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of oxidative stress and antioxidant property using electron spin resonance (ESR) spectroscopy2013

    • Author(s)
      Lee M-C.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 1 Pages: 1-8

    • DOI

      10.3164/jcbn.12-58

    • NAID

      130004879307

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased oxidative stress biomarkers in saliva of down syndrome patients2013

    • Author(s)
      Komatsu T., Yoon D., Ito A., Kurosawa K., Maehata Y., Kubodera T., Ikeda M., Lee M-C
    • Journal Title

      Archives of Oral Biology

      Volume: Vol.58, No.9 Pages: 1246-1250

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Medical-grade collagen peptide in injectables provides antioxidant protection.2013

    • Author(s)
      Kobayashi K, Maehata Y, Okada Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Tokutomi F, Wada-Takahashi S, Komatsu T, Otsuka T, Takahashi SS, Lee MC
    • Journal Title

      Pharmaceutical Development and Technology

      Volume: online Issue: 2 Pages: 1-8

    • DOI

      10.3109/10837450.2013.860547

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased oxidative stress biomarkers in saliva of down syndrome patients2013

    • Author(s)
      Komatsu T., Yoon D., Ito A., Kurosawa K., Maehata Y., Kubodera T., Ikeda M., Lee M-C.
    • Journal Title

      Archives of Oral Biology

      Volume: 58 Issue: 9 Pages: 1246-1250

    • DOI

      10.1016/j.archoralbio.2013.03.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive Oxygen Species Production in Mitochondria of Human Gingival Fibroblast Induced by Blue Light Irradiation2013

    • Author(s)
      Yoshida A, Yoshino F, Makita T, Maehata Y, Higashi K, Miyamoto C, Wada-Takahashi S, Takahashi S-S, Takahashi O, Lee M-C
    • Journal Title

      Journal of Photochemistry and Photobiology B: Biology

      Volume: 129 Pages: 1-5

    • DOI

      10.1016/j.jphotobiol.2013.09.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress and chewing affect blood flow and oxygen levels in the rat brain.2012

    • Author(s)
      Miyake S., Wada-Takahashi S., Honda H., Takahashi SS., Sasaguri K., Sato S., Lee M-C.
    • Journal Title

      Archives of Oral Biology

      Volume: 57(11) Issue: 11 Pages: 1491-1497

    • DOI

      10.1016/j.archoralbio.2012.06.008

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transplantation of side population cells restores the function of damaged exocrine glands through clusterin2012

    • Author(s)
      Mishima K., Inoue H., Nishiyama T., Mabuchi Y., Amano Y., Ide F., Matsui M., Yamada H., Yamamoto G., Tanaka J., Yasuhara R., Sakurai T., Lee M., Chiba K., Sumimoto H., Kawakami Y., Matsuzaki Y., Tsubota K., Saito I
    • Journal Title

      Stem Cells

      Volume: 30 Issue: 9 Pages: 1925-37

    • DOI

      10.1002/stem.1173

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy.2012

    • Author(s)
      Yoshino F., Yoshida A., Wada-Takahashi S., Sugiyama S., Tokutomi F., Maehata Y., Miyamoto C., Komatsu T., Takahashi S-S., Kobayashi K., Lee M-C.
    • Journal Title

      Archives of Oral Biology

      Volume: 57 (6) Issue: 6 Pages: 654-662

    • DOI

      10.1016/j.archoralbio.2011.12.009

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral characteristics of a patient with Ekman-Westborg-Julin trait : a case history2012

    • Author(s)
      Komatsu T., Kurihara T., Ito Y., Lee M-C., Miyagi A., Ikeda M
    • Journal Title

      Special Care Dentistry

      Volume: Vol.32, No.2 Issue: 2 Pages: 70-74

    • DOI

      10.1111/j.1754-4505.2012.00238.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soft-food diet induces oxidative stress in the rat brain2012

    • Author(s)
      Ohno A, Yoshino F, Yoshida A, Hori N, Ono Y, Kimoto K, Onozuka M, Lee M-C
    • Journal Title

      Neuroscience Letters

      Volume: 508 (1) Issue: 1 Pages: 42-46

    • DOI

      10.1016/j.neulet.2011.12.015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gingival vascular functions are altered in type 2 diabetes mellitus model and/or periodontitis model.2012

    • Author(s)
      Sugiyama S.,Lee M-C(12番中12番目).
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 51(2) Pages: 108-113

    • NAID

      130004571484

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of bite-raised condition on the hippocampal cholinergic system of aged SAMP8 mice2012

    • Author(s)
      Katayama T, Mori D, Miyake H, Fujiwara S, Ono Y, Takahashi T,Onozuka M, Kubo KY
    • Journal Title

      Neurosci Lett

      Volume: 520 Pages: 77-81

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: an fMRI approach.2012

    • Author(s)
      Tachibana A, Noah JA, Bronner S, Ono Y, Hirano Y, Niwa M, Watanabe K, Onozuka M
    • Journal Title

      Behav Brain Funct

      Volume: 28 Pages: 8-26

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Active coping with stress suppresses glucose metabolism in the rat hypothalamus2012

    • Author(s)
      Ono Y, Lin HC, Tzen KY, Chen HH, Yang PF, Lai WS, Chen JH, Onozuka M, Yen CT
    • Journal Title

      Stress

      Volume: 15 Pages: 207-217

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain2011

    • Author(s)
      Yoshino F, Yoshida A., Umigai N., Kubo K., Lee M-C.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 3 Pages: 182-187

    • DOI

      10.3164/jcbn.11-01

    • NAID

      130004466653

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soft-food diet induces oxidative stress in the rat brain.2011

    • Author(s)
      Ohno A., Yoshino F., Yoshida A., Hori N., Ono Y., Kimoto K., Onozuka M., Lee M-C
    • Journal Title

      Neuroscience Letters

      Volume: 508 Pages: 42-46

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crocetin reduces the oxidative stress induced reactive oxygen species in the SHRSPs brain.2011

    • Author(s)
      Yoshino F., Yoshida A., Umigai N., Kubo K., Lee M-C.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Pages: 182-187

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects.2011

    • Author(s)
      Yoshino F., Yoshida A., Sugiyama S., Tokutomi F., Miyamoto C., Maehata Y., Kobayashi K., Wada-Takahashi S., Maetani T., Okada E., Okada Y., Komatsu T., Takahashi S-S., Wan J., Lee M-C
    • Journal Title

      Anti-Aging Medicine

      Volume: 8 Pages: 48-52

    • NAID

      130000968342

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Direct Assessment of the Antioxidant Properties of Midazolam by Electron Spin Resonance Spectroscopy.2011

    • Author(s)
      Hata M., Kobayashi K., Yoshino F., Yoshida A., Sugiyama S., Miyamoto C., Tokutomi F., Maehata Y., Wada-Takahashi S., Takahashi S-S., Komatsu T., Yoshida K., Lee M-C
    • Journal Title

      Journal of Anesthesia

      Volume: 25 Pages: 765-769

    • NAID

      10031137045

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy.2011

    • Author(s)
      Kobayashi K., Maehata Y., Kawamura Y., Kusubata M., Hattori S., Tanaka K., Miyamoto C., Yoshino F., Yoshida A., Wada-Takahashi S., Komatsu T., Takahashi S-S., Lee M-C
    • Journal Title

      Journal of Pharmacological Science

      Volume: 116 Pages: 97-106

    • NAID

      10029894130

    • Related Report
      2011 Research-status Report
  • [Presentation] 簡易なESR法による放射線被曝線量法測定法の確立のための基礎的研究とヒトへの応用第 2 報2014

    • Author(s)
      李 昌一,斉田牧子,小林 杏, 吉田彩佳,大塚剛郎,小松知子,櫻井 孝, 三宅 実, Harold M. Swartz,Ann B. Flood, 吉野文彦
    • Organizer
      第2回 災害医療歯科学研究報告会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] Down 症候群患者における口腔内Candida 菌と唾液中活性酸素種の関連性2013

    • Author(s)
      小松知子,植田郁子,大塚剛郎, 早野 愛,阪本貴史, 中村ミゲル, 村井朋代,井田侑子,池田正一,宮城 敦,浜田信城, 李 昌一
    • Organizer
      第30回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 若年ダウン症候群における唾液中ヒスタミン5含有量とCandida 菌分離頻度に関する検討2013

    • Author(s)
      李 昌一,小松知子,植田郁子,伊藤 愛,村井朋代,井田郁子,池田正一,宮城 敦,浜田信城
    • Organizer
      第6回日本口腔検査学会総会・学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] 嚥下体操の嚥下関連筋に対する効果-高齢者と若年者との比較-2013

    • Author(s)
      小松知子,植田晃弘,小野弓絵,宮城 敦,浜田信城, 李 昌一
    • Organizer
      第19回日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] Salivary histatin levels and fungal colonisation in Down syndrome2013

    • Author(s)
      Komatsu T, Kumada H, Helmerhorst, E J, Salih E, Oppenheim FG, Hamada N, Lee C-II
    • Organizer
      101th FDI 2013 World Dental congress
    • Place of Presentation
      Istanbul
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Down 症候群患者の唾液中活性酸素消去能と歯周病の関連性2013

    • Author(s)
      小松 知子,大塚剛郎,岡部愛子,小林杏,前谷崇志,宮城敦,池田正一,李 昌一
    • Organizer
      第13回日本抗加齢医学会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗酸化療法はどこまで進んでいるのか?-アンチエイジング医学臨床応用への可能性2013

    • Author(s)
      李 昌一
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 嚥下体操は飲水に必要な筋活動を軽減する2013

    • Author(s)
      植田晃弘,小野弓絵,小松知子,李昌一
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病における唾液中活性酸素の作用 -Down 症候群患者における検討-2013

    • Author(s)
      小松知子、大塚剛郎、高野知子、宮城敦、李昌一
    • Organizer
      日本老年歯科医学会第24回学術大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 「In vivo ESRの発展とその医学応用 -故横山秀克先生メモリアルシンポジウム-」2013

    • Author(s)
      李 昌一
    • Organizer
      第52回電子スピンサイエンス学会年会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Annual Research Report
  • [Presentation] Down症候群患者における口腔内Candida菌と唾液中活性酸素種の関連性2013

    • Author(s)
      小松知子,植田郁子,大塚剛郎, 早野 愛,阪本貴史, 中村ミゲル, 村井朋代,井田侑子,池田正一,宮城 敦,浜田信城, 李 昌一
    • Organizer
      第30回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 嚥下体操の嚥下関連筋に対する効果−高齢者と若年者との比較−2013

    • Author(s)
      小松知子,植田晃弘,小野弓絵,宮城 敦,浜田信城, 李 昌一
    • Organizer
      第19回日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化ストレスの診断と対処法, 歯周病治療・検査法開発に向けた酸化ストレス測定技術の応用2013

    • Author(s)
      李 昌一
    • Organizer
      第6回日本口腔検査学会総会・学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 薬物療法上の問題点2013

    • Author(s)
      李 昌一
    • Organizer
      神経障害性疼痛関連歯科学会合同シンポジウム企画
    • Place of Presentation
      埼玉
    • Related Report
      2013 Annual Research Report
  • [Presentation] Porphyomonas gingivalis感染による口腔内微小循環血流量の変調に対するAOB研究2013

    • Author(s)
      高橋聡子,徳富文彬,杉山秀太,宮本千央,吉田彩佳,小林 杏,前畑洋次郎,遠山歳三,吉野文彦,浜田信城,高橋俊介,李 昌一
    • Organizer
      第13回AOB研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯科治療に用いられる青色光照射が血管平滑筋へおよぼす影響2013

    • Author(s)
      吉田彩佳,吉野文彦,前畑洋次郎,宮本千央,高橋聡子,高橋俊介,李 昌一
    • Organizer
      第13回AOB研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Down 症候群患者の唾液中活性酸素消去能と歯周病の関連性2013

    • Author(s)
      小松 知子,大塚剛郎,岡部愛子,小林杏,前谷崇志,宮城敦,池田正一,李昌一
    • Organizer
      第13回日本抗加齢医学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗酸化療法はどこまで進んでいるのか?-アンチエイジング医学臨床応用への可能性2013

    • Author(s)
      李 昌一
    • Organizer
      第13回日本抗加齢医学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 嚥下体操は飲水に必要な筋活動を軽減する2013

    • Author(s)
      植田晃弘,小野弓絵,小松知子,李昌一
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] いつまでも若々しく2013

    • Author(s)
      李 昌一
    • Organizer
      窓梅会総会
    • Place of Presentation
      神奈川県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「活性酸素・活性窒素計測」2013

    • Author(s)
      李 昌一
    • Organizer
      第66回日本酸化ストレス学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周病における唾液中活性酸素の作用 -Down症候群患者における検討-2013

    • Author(s)
      小松知子、大塚剛郎、高野知子、宮城敦、李昌一
    • Organizer
      日本老年歯科医学会第24回学術大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電子スピン共鳴法を応用した唾液抗酸化作用による歯周病評価法の可能性2012

    • Author(s)
      吉野 文彦,吉田 彩佳,李 昌一
    • Organizer
      日本歯科保存学会 2012年度 春季学術大会(第136回)
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔機能を活かすことで活性酸素を減らすアンチエイジングライフの実現-幸福な人生は歯の健康から-2012

    • Author(s)
      李 昌一
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢 Down症候群患者の日常生活動作 (ADL) と歯科的所見との関連性2012

    • Author(s)
      小松知子, 植田郁子,坂本貴史,熊田秀文,伊藤 愛,高野知子,岡部愛子,鶴屋俊輔,小林 杏,前谷崇志,浜田信城,宮城 敦,池田正一,李 昌一
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] 唾液抗酸化能を用いた客観的歯周病評価法の検討2012

    • Author(s)
      吉野 文彦,吉田 彩佳,高橋 聡子,徳富 文彬,李 昌一
    • Organizer
      第65回酸化ストレス学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of Salivary Antioxidant Activity Involved in Periodontitis2012

    • Author(s)
      Yoshino F., Yoshida A., Wada-Takahashi S., Tokutomi F., Lee M-C
    • Organizer
      2012 FDI Annual World Dental Congress
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔機能を活かすことで活性酸素を減らすアンチエイジングライフの実現 -幸福な人生は歯の健康から-,2012

    • Author(s)
      李 昌一
    • Organizer
      第 12 回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 嚥下体操による飲み込みやすさの変化:筋電図による検討Upper-body exercise changes electromyographic patterns with swallowing.2012

    • Author(s)
      植田晃弘,峯岸祐子,小野弓絵,小松知子,李昌一
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 嚥下体操の嚥下関連筋に対する効果‐表面筋電図による検討‐Effects of Upper-body exercise on swallowing - related muscles -Evaluation in surface electromyographic patterns-.2012

    • Author(s)
      小松知子,植田晃弘,峯岸祐子,小野弓絵,宮城 敦,李昌一
    • Organizer
      第17回・18回共催 日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 電子スピン共鳴 (ESR) 法の生物医学応用 -活性酸素による酸化ストレスの足跡を求めて-.2011

    • Author(s)
      李 昌一
    • Organizer
      第 64 回日本酸化ストレス学会学術集会(招待講演)
    • Place of Presentation
      虻田郡、北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] 電子スピン共鳴(ESR)法による抗酸化能評価技術の基礎と臨床応用2011

    • Author(s)
      李 昌一
    • Organizer
      4回AAASOM口腔先端応用医科学会議(招待講演)
    • Place of Presentation
      御茶ノ水
    • Related Report
      2011 Research-status Report
  • [Presentation] 抗酸化歯科治療の基礎と臨床の実際

    • Author(s)
      李 昌一
    • Organizer
      第3回抗酸化歯科研究会学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 表面筋電図による嚥下体操における嚥下関連筋に対する効果の検討

    • Author(s)
      小松知子,植田晃弘,峯岸祐子,小野弓絵,宮城 敦,李昌一
    • Organizer
      神奈川県地域歯科医療研修会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 病態における酸化ストレスマーカーの現状と新展開

    • Author(s)
      李 昌一
    • Organizer
      第15回日本心血管内分泌代謝学会学術総会(招待講演)
    • Place of Presentation
      2011. 11. 25-26
    • Related Report
      2011 Research-status Report
  • [Presentation] ESR で抗酸化能を計る

    • Author(s)
      李 昌一
    • Organizer
      食品開発展(招待講演)
    • Place of Presentation
      2011. 10. 7.
    • Related Report
      2011 Research-status Report
  • [Presentation] 唾液を用いた抗酸化能評価の基礎的研究と臨床応用.

    • Author(s)
      李 昌一
    • Organizer
      第53回歯科基礎医学会学術大会・総会(招待講演)
    • Place of Presentation
      2011. 9. 30.
    • Related Report
      2011 Research-status Report
  • [Presentation] チタンインプラントのオッセオインテグレーションに関与する活性酸素の役割.

    • Author(s)
      李 昌一
    • Organizer
      第41回 公益社団法人日本口腔インプラント学会・学術大会(招待講演)
    • Place of Presentation
      2011. 9. 18.
    • Related Report
      2011 Research-status Report
  • [Presentation] 歯科疾患・歯科臨床における酸化ストレスの病態生理学的意義と臨床展開.

    • Author(s)
      李 昌一:
    • Organizer
      第 64 回日本酸化ストレス学会学術集会
    • Place of Presentation
      2011. 7. 2-3.
    • Related Report
      2011 Research-status Report
  • [Presentation] 唾液を用いた抗酸化能評価技術の最前線.

    • Author(s)
      李 昌一
    • Organizer
      第 10 回国際バイオ EXPO 国際バイオフォーラム
    • Place of Presentation
      2011. 6. 29-7.1.
    • Related Report
      2011 Research-status Report
  • [Presentation] ESR で抗酸化能を計る.

    • Author(s)
      李 昌一
    • Organizer
      第 11 回日本抗加齢医学会総会(招待講演)
    • Place of Presentation
      2011. 5. 27-29.
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規生活習慣病検査を目指した口腔酸化ストレス・抗酸化能評価.

    • Author(s)
      李 昌一
    • Organizer
      第 11 回日本抗加齢医学会総会
    • Place of Presentation
      2011. 5. 27-29
    • Related Report
      2011 Research-status Report
  • [Presentation] 電子スピン共鳴 (ESR) 法による食品機能性評価の最前線.

    • Author(s)
      李 昌一
    • Organizer
      第 15 回国際食品素材/添加物展会議
    • Place of Presentation
      2011.5.19.
    • Related Report
      2011 Research-status Report
  • [Book] 第4章 抗酸化機能の基準化に向けた取り組み, 抗酸化素材の開発と市場2014

    • Author(s)
      李 昌一, (編者) シーエムシー出版
    • Publisher
      シーエムシー出版, 東京
    • Related Report
      2013 Final Research Report
  • [Book] 唾液を用いた抗酸化能測定の新規口腔検査への可能性,食品と開発, Vol.49, No.12014

    • Author(s)
      李 昌一
    • Publisher
      食品と開発
    • Related Report
      2013 Final Research Report
  • [Book] (編者)鈴木敬一郎,活性酸素の本当の姿,「目からウロコのヘルスサイエンスシリーズ」第2巻『活性酸素の本当の姿』第4章活性酸素はどう計るか2013

    • Author(s)
      李 昌一
    • Publisher
      ナップ社
    • Related Report
      2013 Final Research Report
  • [Book] Role of Oxidative stress and Antioxidant system on Periodontal disease. Studies on Gingivitis and Periodontal Disesase,Series : Oxidative Stress in Applied Basic Research and Clinical Practice2013

    • Author(s)
      Lee M-C., (Eds.) Ekuni D
    • Publisher
      Human Press, c/o Springer Science+Business Media
    • Related Report
      2013 Final Research Report
  • [Book] Oxidative stress and Periodontal disease in Down syndrome. Studies on Gingivitis and Periodontal Disesase, Series : Oxidative Stress in Applied Basic Research and Clinical Practice, Series : Oxidative Stress in Applied Basic Research and Clinical Practice2013

    • Author(s)
      Komatsu T., Lee M-C., (Eds.) Ekuni D
    • Publisher
      Human Press, c/o Springer Science+Business Media
    • Related Report
      2013 Final Research Report
  • [Book] Oxidative Stress in Applied Basic Research and Clinical Practice2013

    • Author(s)
      Komatsu T., Lee M-C., (Eds.) Ekuni D.
    • Total Pages
      13
    • Publisher
      Human Press, c/o Springer Science+Business Media
    • Related Report
      2013 Annual Research Report
  • [Book] Oxidative Stress in Applied Basic Research and Clinical Practice2013

    • Author(s)
      Lee M-C., (Eds.) Ekuni D
    • Total Pages
      12
    • Publisher
      Human Press, c/o Springer Science+Business Media
    • Related Report
      2013 Annual Research Report
  • [Book] 「目からウロコのヘルスサイエンスシリーズ」2013

    • Author(s)
      李 昌一, (編者)鈴木敬一郎
    • Total Pages
      19
    • Publisher
      ナップ社
    • Related Report
      2013 Annual Research Report
  • [Book] Assessment of Oxidative Stress in the Brain of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat Using by Electron Spin Resonance Spectroscopy. Studies on Experimental Models, Series : Oxidative Stress in Applied Basic Research and Clinical Practice2011

    • Author(s)
      Yoshino F., Kobayashi K., Lee M-C., (Eds.) Basu Samar., Wiklund Lars
    • Publisher
      Human Press, c/o Springer Science+Business Media
    • Related Report
      2013 Final Research Report
  • [Book] 皮膚における UV 照射による酸化ストレスと抗酸化剤による UV 防御作用,食品と開発2011

    • Author(s)
      吉田彩佳, 吉野文彦, 李 昌一
    • Publisher
      UBM メディア株式会社
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.labs.kdu.ac.jp/yakuri/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.aoxdent.org/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.graduate.kdu.ac.jp/saigai/research/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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