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Psychological stress evaluation using biochemical substances derived from human intercellular-fluid, nail, and hair samples

Research Project

Project/Area Number 23680023
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sensitivity informatics/Soft computing
Research InstitutionNagaoka University of Technology

Principal Investigator

NOMURA SHUSAKU  長岡技術科学大学, 工学(系)研究科(研究院), 准教授 (80362911)

Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsストレス / 感性生理学 / 感性情報学 / 実験系心理学 / 精神神経内分泌学 / 精神神経免疫学
Outline of Final Research Achievements

Psychological stress on human leads to hypersecretion of hippocampus-pituitary-adrenal (HPA) hormones as typified by cortisol. Thus these hormones are called as “stress hormone.” The objective of this study is: (1) to develop the technique to determine such stress hormones from human intercellular fluid, hair, and nail sample and (2) to test the feasibility of these hormones as an objective stress measure. As a result of this project, the variety of stress hormones, including sexual hormones such as testosterone, were successfully determined with the subject’s intercellular fluid, hair, and nail sample. The efficacy of these hormones as the stress measure was illustrated with the subjects who engaged in a long term on-the-job-training.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (60 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (47 results) (of which Invited: 4 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 就寝中のラベンダー呈示が起床後の唾液中コルチゾール分泌に及ぼす影響2014

    • Author(s)
      大平雅子, 高原円, 佐藤誠也, 藤川豊成, 伊藤兼敏, 野村収作
    • Journal Title

      生体医工学

      Volume: 52(6) Pages: 282-287

    • NAID

      130005084156

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 青色のストレス反応抑制効果-唾液コルチゾールによる検証2014

    • Author(s)
      野村収作
    • Journal Title

      映像メディア学会誌

      Volume: 68(12) Pages: 537-539

    • NAID

      130004705961

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 就寝中の香り呈示が起床後の唾液中コルチゾールに及ぼす影響に関する予備的検討2014

    • Author(s)
      大平雅子, 高原円, 伊藤兼敏, 野村収作
    • Journal Title

      日本味と匂い学会誌

      Volume: 21(1) Pages: 69-76

    • NAID

      110009810341

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Effect of an Alerting Odorant on Human Cortisol Secretion during Sleep2013

    • Author(s)
      大平雅子, 伊藤兼敏, 野村収作
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 133 Issue: 6 Pages: 1277-1278

    • DOI

      10.1541/ieejeiss.133.1277

    • NAID

      10031175312

    • ISSN
      0385-4221, 1348-8155
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Pilot Study on the Effect of Music-heart Beat Feedback System on Human Heart Activity2013

    • Author(s)
      Shusaku Nomura, Keita Yoshimura, Yoshimasa Kurosawa
    • Journal Title

      Journal of Medical Informatics and Technologies

      Volume: 22 Pages: 251-256

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Pulse Wave Measurement toward Estimating Condition of Human Arteries2013

    • Author(s)
      Shusaku Nomura, Yasushi Hanasaka, and Hiroshi Ogawa
    • Journal Title

      IADIS International Journal on WWW/Internet

      Volume: 11(3) Pages: 116-125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 微細針穿孔法による起床時コルチゾール反応の経皮的な評価2012

    • Author(s)
      野村収作
    • Journal Title

      ライフサポート

      Volume: 24(2) Pages: 48-55

    • NAID

      10031003626

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skin Temperature as a Possible Indicator of Student’s Involvement in e-Learning Sessions2012

    • Author(s)
      Shusaku Nomura
    • Journal Title

      International Journal of Electronic Commerce Studies

      Volume: 3(1) Pages: 101-110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Pulse Wave Detection Using Multiple Silicon Microphones toward Human Somatic State Evaluation2012

    • Author(s)
      Shusaku Nomura
    • Journal Title

      Information Technology Journal

      Volume: 11(4) Issue: 4 Pages: 476-479

    • DOI

      10.3923/itj.2012.476.479

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体液中コルチゾールの経皮的な定量の試み2012

    • Author(s)
      鈴木健太
    • Journal Title

      電子情報通信学会和文誌D

      Volume: J-95D(1) Pages: 162-165

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 唾液中Cortisol, sIgA,α-amylase濃度の睡眠時変化特性2012

    • Author(s)
      大平雅子
    • Journal Title

      生体医工学

      Volume: 49(6) Pages: 798-804

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 香り刺激を用いた睡眠中の事象関連電位の予備的検討2014

    • Author(s)
      高原円, 佐藤誠也, 藤川豊成, 大平雅子, 伊藤兼敏,野村収作
    • Organizer
      第44回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 長期インターンシップ従事者の生理・心理ストレス評価―新卒者が経験する心身ストレスのモデル・スタディとして2014

    • Author(s)
      大平雅子,野村収作
    • Organizer
      第30回日本ストレス学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] A pilot study on the olfactory evoked potential during sleep with jasmine and lavender2014

    • Author(s)
      Shusaku Nomura, Masaya Sato, Toyonari Fujikawa, Madoka Takahara, Masako Hasegawa-Ohira, and Kanetoshi Ito
    • Organizer
      International Journal of Psychophysiology
    • Place of Presentation
      Hiroshima (Japan)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Enhancement of nightlong salivary melatonin secretion by a feeble light exposure during sleep2014

    • Author(s)
      Shusaku Nomura and Yoshimune Kato
    • Organizer
      the 22nd Congress of the European Sleep Research Society
    • Place of Presentation
      Tallinn (Estonia)
    • Year and Date
      2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] First-night effect on heart rate variability and salivary cortisol secretion2014

    • Author(s)
      Madoka Takahara, Masako Hasegawa-Ohira, Kanetoshi Ito, and Shusaku Nomura
    • Organizer
      the 22nd Congress of the European Sleep Research Society
    • Place of Presentation
      Tallinn (Estonia)
    • Year and Date
      2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 四ヶ月間のインターンシップにおける生理的ストレス評価研究-唾液ストレス・バイオマーカーによる短期前向き研究2014

    • Author(s)
      野村収作
    • Organizer
      第16回日本感性工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effect of inhalation of lavender and jasmine essential oils on salivary cortisol secretion during sleep and after awakening2014

    • Author(s)
      Masako Hasegawa-Ohira, Madoka Takahara, Masaya Sato, Toyonari Fujikawa, Kanetoshi Ito and Shusaku Nomura
    • Organizer
      44th annual international Society for Psychoneuroendocrinology conference
    • Place of Presentation
      Montreal (Canada)
    • Year and Date
      2014-08-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自律神経系および内分泌系における第一夜効果の評価2014

    • Author(s)
      高原円, 大平雅子, 佐藤誠也, 藤川豊成, 佐久間裕貴, 伊藤兼敏, 野村収作
    • Organizer
      日本睡眠学会第39回定期学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 就寝中の香り呈示が唾液中コルチゾールに及ぼす影響2014

    • Author(s)
      大平雅子, 高原円, 佐藤誠也, 藤川豊成, 伊藤兼敏, 野村収作
    • Organizer
      日本睡眠学会第39回定期学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 就寝中のラベンダー呈示が内分泌系に及ぼす影響2014

    • Author(s)
      佐藤 誠也, 藤川 豊成, 伊藤 兼敏, 高原 円, 大平 雅子, 野村収作
    • Organizer
      第2回アンビエント・フィードバック・システム(AFS)研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 精神作業負荷時におけるラベンダーおよびジャスミの介入効果に関する基礎研究2014

    • Author(s)
      前山賢人, 伊藤 兼敏, 野村収作
    • Organizer
      第2回アンビエント・フィードバック・システム(AFS)研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Computational Approach toward the Estimation of the Mental Workload with Physiological Signals2013

    • Author(s)
      Shusaku Nomura and Handri Santoso
    • Organizer
      ADIS International conference, Intelligent Systems and Agents 2013
    • Place of Presentation
      Prague (Czech Republic)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effect of lavender inhalation on salivary IgA and cortisol secretion after awakening2013

    • Author(s)
      Masako Hasegawa-Ohira, Madoka Takahara, Kanetoshi Ito, and Shusaku Nomura
    • Organizer
      43rd Annual Meeting of the International Society of Psychoneuroendocrinology
    • Place of Presentation
      Leiden (The Netherlands)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Suppression of Salivary Cortisol Secretion by an Exposure of Alerting Odorant during Sleep2013

    • Author(s)
      Masako Hasegawa-Ohira, Kanetoshi Ito, and Shusaku Nomura
    • Organizer
      Society for Psychophysiological Research 53rd Annual Meeting
    • Place of Presentation
      Florence (Italy)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 睡眠中のラベンダーの香り呈示が起床時のコルチゾール分泌に及ぼす影響2013

    • Author(s)
      大平雅子, 高原円, 伊藤兼敏, 野村収作
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 呼吸-姿勢フィードバック・システムによる呼吸制御の試み2013

    • Author(s)
      中村悦久, 三井大和, 野村収作
    • Organizer
      第1回アンビエント・フィードバック・システム(AFS)研究会
    • Place of Presentation
      長岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多チャンネルMEMS-ECMによる脈波測定系の検討2013

    • Author(s)
      柳瀬玲於, 野村収作
    • Organizer
      第1回アンビエント・フィードバック・システム(AFS)研究会
    • Place of Presentation
      長岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 音楽-心拍フィードバックが自律神経系・内分泌系に及ぼす影響に関する検討2013

    • Author(s)
      芳村啓太, 野村収作
    • Organizer
      第1回アンビエント・フィードバック・システム(AFS)研究会
    • Place of Presentation
      長岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 就寝中のラベンダーおよびジャスミン呈示が内分泌系に及ぼす影響に関する基礎研究2013

    • Author(s)
      佐藤誠也, 藤川豊成, 野村収作
    • Organizer
      第1回アンビエント・フィードバック・システム(AFS)研究会
    • Place of Presentation
      長岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 睡眠時における唾液中生化学物質の変動と心理指標との関連2013

    • Author(s)
      大平雅子, 須栗一路, 野村収作
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2013
    • Place of Presentation
      甲府
    • Related Report
      2013 Annual Research Report
  • [Presentation] 色環境がホルモン分泌に及ぼす影響-HPA系とSAM系のストレス反応における対比-2013

    • Author(s)
      野村収作, 伊藤光一, 大平雅子
    • Organizer
      平成25年度照明学会第46回全国大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] LED照明介入下における就寝中のメラトニン分泌2013

    • Author(s)
      大平雅子, 加藤吉宗, 須栗一路, 野村収作
    • Organizer
      平成25年度照明学会第46回全国大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 呼吸と同期した姿勢制御系による呼吸調整の検証2013

    • Author(s)
      野村収作, 久須美 朗
    • Organizer
      第29回 日本ストレス学会学術総会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体の不随意機能制御技術としてのアンビエント・フィードバック・システム2013

    • Author(s)
      野村収作
    • Organizer
      高砂香料工業株式会社
    • Place of Presentation
      湘南
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 抗ストレス効果を科学する2013

    • Author(s)
      野村収作
    • Organizer
      日本心理学会第77回大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Variations in Salivary Secreted Hormones and Immune Substances of Male University Students during their Final Examinations2012

    • Author(s)
      Shusaku Nomura
    • Organizer
      70th Annual Scientific Meeting of American Psychosomatic Society
    • Place of Presentation
      Athens (Greece)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Variations in the secretion of salivary Cortisol, Immunoglobulin A, and DHEA while asleep and after awakening, and its association with psychological sleep condition2012

    • Author(s)
      Masako Hasegawa-Ohira
    • Organizer
      70th Annual Scientific Meeting of American Psychosomatic Society
    • Place of Presentation
      Athens (Greece)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 労働者のストレスとホルモン~"私は平気"は要注意2012

    • Author(s)
      野村収作
    • Organizer
      燕中央倫理法人会
    • Place of Presentation
      燕(招待講演)
    • Year and Date
      2012-02-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 唾液の経時的採集による睡眠時の唾液メラトニン分泌の検証2011

    • Author(s)
      加藤吉宗
    • Organizer
      平成23年度日本生理人類学会研究奨励発表会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 睡眠時における唾液中IgA濃度と睡眠感との関連2011

    • Author(s)
      大平雅子
    • Organizer
      第27回日本ストレス学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 睡眠時における唾液中DHEA-S濃度と主観的ストレス感との関連2011

    • Author(s)
      大平雅子
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 学習とストレス2011

    • Author(s)
      野村収作
    • Organizer
      eラーニング高等教育連携(eHELP)全体会議
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] ホルモンによる快・不快評価、感性評価2011

    • Author(s)
      野村収作
    • Organizer
      技術シーズプレゼンテーションin魚沼
    • Place of Presentation
      魚沼(招待講演)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 唾液ホルモンによる睡眠様態の理解2011

    • Author(s)
      大平雅子
    • Organizer
      日本生理人類学会第64回大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 経皮的に採取した組織液を用いたストレスホルモンの評価2011

    • Author(s)
      野村収作
    • Organizer
      日本生理人類学会第64回大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] eラーニングにおける学習者バイオ情報に関する研究2011

    • Author(s)
      野村収作
    • Organizer
      情報処理学会第4回教育学習支援情報システム研究会(CLE)
    • Place of Presentation
      長岡(招待講演)
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alleviation of the Stress-induced Hypothalamus-pituitary-adrenal (HPA) System Enhancement by Blue Color

    • Author(s)
      Shusaku Nomura
    • Organizer
      12th International Congress of Behavioral Medicine
    • Place of Presentation
      Budapest (Hungary)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Variations in the secretion of salivary dehydroepiandrosterone (DHEA) after awakening and its psychological association with sleep state

    • Author(s)
      Masako Hasegawa-Ohira
    • Organizer
      12th International Congress of Behavioral Medicine
    • Place of Presentation
      Budapest (Hungary)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Objective Evaluation of e-learning Contents Based on Biological Signals

    • Author(s)
      Kuniaki Yajima
    • Organizer
      The Second International Symposium on Technology for Sustainability
    • Place of Presentation
      Bangkok (Thailand)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 睡眠時における唾液中生化学物質濃度の変動と睡眠感との関連-IgA,DHEA-Sによる検討

    • Author(s)
      大平雅子
    • Organizer
      第82回日本衛生学会学術総会資料
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] e-learning受講中の生体情報を用いたコンテンツの質の評価に関する実験

    • Author(s)
      矢島邦昭
    • Organizer
      第7回教育学習支援情報システム研究発表会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 微細針技術による経皮的なストレスバイオマーカーの定量評価

    • Author(s)
      中村悦久
    • Organizer
      第16回精神神経内分泌免疫学研究集会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 毛髪・爪・組織液からのコルチゾールの定量手法の検討

    • Author(s)
      野村収作
    • Organizer
      生活生命支援医療福祉工学系学会連合大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 香り刺激が睡眠時のコルチゾール分泌に及ぼす影響の検証

    • Author(s)
      大平雅子
    • Organizer
      第28回日本ストレス学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 微細針技術によるストレス関連ホルモンの経皮的評価

    • Author(s)
      野村収作
    • Organizer
      第28回日本ストレス学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] An introduction for Ambient Biomedical Engineering

    • Author(s)
      Shusaku Nomura
    • Organizer
      Faculty of Computer Science, University of Indonesia
    • Place of Presentation
      Jakarta (Indonesia)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 無侵襲で測るストレス-熱画像・ホルモン分泌・血行力学

    • Author(s)
      野村収作
    • Organizer
      日本サーモロジー学会第29回大会
    • Place of Presentation
      長岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Biomarker2012

    • Author(s)
      Shusaku Nomura
    • Total Pages
      402
    • Publisher
      InTech
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.nagaokaut.ac.jp/j/annai/NUT-toprun/NUT-toprun.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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