Epigenetic landscape defined by artificial genetic circuit
| Project/Area Number |
23680031
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KIGA Daisuke 東京工業大学, 総合理工学研究科(研究院), 准教授 (30376587)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2013: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2012: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 人工遺伝子回路 / 合成生物学 / エピジェネティック・ランドスケープ / 数理モデル / 分化 |
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| Outline of Final Research Achievements |
Cell diversification in multi-cellular organism can be described by a trajectory on a programed landscape which is defied by molecular networks inside and between cells. Especially in such networks between cells, allocations of cells are an important parameter of the program. Here, artificial genetic circuits constructed in this study are used for pursuing mechanisms in cell diversification process.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling2011
Author(s)
Sekine, R., Yamamura, M., Ayukawa, S., Ishimatsu, K., Akama, S., Takinoue, M., Hagiya, M., Kiga, D.
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Journal Title
Proc.Natl.Acad.Sci.U.S.A.
Volume: 108
Issue: 44
Pages: 17969-17973
DOI
Related Report
Peer Reviewed
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