Regulatory mechanism of basal ganglia circuit in reward and aversive behavior and decision-making
| Project/Area Number |
23680034
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University (2012-2014)
Osaka Bioscience Institute (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 大脳基底核 / 神経回路 / 報酬行動 / 忌避行動 / 可塑性 / 意思決定 / ドーパミン受容体 / 薬物依存症 / コカイン / 黒質網様部 / Eph受容体 |
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| Outline of Final Research Achievements |
We evaluated regulatory mechanism of basal ganglia circuit in reward and aversive behavior and decision-making, using reversible neurotransmission blocking technique, in which transmission of the direct and indirect pathways was selectively and reversibly blocked. We have found that the activation of D1 dopamine receptors and the inactivation of D2 dopamine receptors postsynaptically control reward and aversive behavior in a direct pathway-specific and indirect pathway-specific manner, respectively. Furthermore, we have revealed that reward and aversive behavior is regulated by pathway-specific neural plasticity via selective transmitter receptors in the basal ganglia circuit.
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Report
(5 results)
Research Products
(67 results)
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[Journal Article] Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors.2013
Author(s)
Hikida, T., Yawata, S., Yamaguchi, T., Danjo, T., Sasaoka, T., Wang, Y. & Nakanishi,S
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Journal Title
Proc.Natl.Acad.Sci.USA
Volume: 110
Issue: 1
Pages: 342-347
DOI
Related Report
Peer Reviewed
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[Journal Article] Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.2013
Author(s)
Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A
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Journal Title
Science
Volume: Vol. 339
Issue: 6117
Pages: 335-339
DOI
Related Report
Peer Reviewed
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