| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
We evaluated regulatory mechanism of basal ganglia circuit in reward and aversive behavior and decision-making, using reversible neurotransmission blocking technique, in which transmission of the direct and indirect pathways was selectively and reversibly blocked. We have found that the activation of D1 dopamine receptors and the inactivation of D2 dopamine receptors postsynaptically control reward and aversive behavior in a direct pathway-specific and indirect pathway-specific manner, respectively. Furthermore, we have revealed that reward and aversive behavior is regulated by pathway-specific neural plasticity via selective transmitter receptors in the basal ganglia circuit.
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