Developmental dynamics of mouse olfactory circuits
| Project/Area Number |
23680038
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IMAI TAKESHI 独立行政法人理化学研究所, 発生・再生科学総合研究センター, チームリーダー (70509851)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 樹状突起 / 刈り込み / 嗅球 / 僧帽細胞 / 嗅覚 / NMDA受容体 / GABA / 神経活動 / シナプス除去 / 嗅覚系 / 僧帽・房飾細胞 / in vivoイメージング / シナプス形成 / 神経再生 |
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| Research Abstract |
In the mouse olfactory bulb, inputs from olfactory sensory neurons are relayed to second-order neurons, mitral and tufted cells. A mitral/tufted cell extends a single primary dendrite toward a glomerulus, as well as several lateral dendrites. A mitral/tufted cell initially extends multiple dendrites to glomeruli, but they prune all but one dendrite and thereby establish a single primary dendrite during the first postnatal week. In this study, we established a method for quantitative analyses of mitral cell dendrites. We also found that neuronal activity plays an important role in the dendrite pruning process.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons2013
Author(s)
Nakashima A., Takeuchi H., Imai T., Saito H., Kiyonari H., Abe T., Chen A., Weinstein L.S., Yu C.R., Storm D.R., Nishizumi H., and Sakano H
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Journal Title
Cell
Volume: 154
Issue: 6
Pages: 1314-1325
DOI
Related Report
Peer Reviewed
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