| Project/Area Number |
23680038
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IMAI TAKESHI 独立行政法人理化学研究所, 発生・再生科学総合研究センター, チームリーダー (70509851)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 樹状突起 / 刈り込み / 嗅球 / 僧帽細胞 / 嗅覚 / NMDA受容体 / GABA / 神経活動 / シナプス除去 / 嗅覚系 / 僧帽・房飾細胞 / in vivoイメージング / シナプス形成 / 神経再生 |
|---|
| Research Abstract |
In the mouse olfactory bulb, inputs from olfactory sensory neurons are relayed to second-order neurons, mitral and tufted cells. A mitral/tufted cell extends a single primary dendrite toward a glomerulus, as well as several lateral dendrites. A mitral/tufted cell initially extends multiple dendrites to glomeruli, but they prune all but one dendrite and thereby establish a single primary dendrite during the first postnatal week. In this study, we established a method for quantitative analyses of mitral cell dendrites. We also found that neuronal activity plays an important role in the dendrite pruning process.
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