|Budget Amount *help
¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|Outline of Final Research Achievements
After brain injury, immature new neurons generated in the adult ventricular-subventricular zone (V-SVZ) migrate toward injured areas through the dense meshwork of activated astrocytes to regenerate neurons. However, their number and migration efficiency are insufficient to induce functional recovery. Using a mouse model of ischemic stroke, we found that V-SVZ-derived new neurons secrete the Slit1 protein, a ligand for Robo2 expressed in activated astrocytes. The Slit-Robo signaling causes cytoskeletal modification in the astrocytes in contact with new neurons, which increases the efficiency of neuronal migration. Moreover, overexpression of Slit1 in the new neurons promotes their migration toward the injured area. These findings may contribute to the development of new strategies for the treatment of neurological diseases using the endogenous neuro-regeneration system.