| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Outline of Final Research Achievements |
Oligodendrocytes can respond to neuronal activity with prolonged depolarization of membrane potential. To understand the functional significance of oligodendrocytic depolarization, we used transgenic animals in which oligodendrocytes expressed channelrhodopsin-2 and examined the neuronal responses. We demonstrated that illumination-triggered depolarization of oligodendrocytes induced early- and late-onset facilitation of axonal conduction; the former lasted for approximately 10 min, whereas the latter continued for up to 3 h. These results suggested that oligodendrocyte depolarization induces short- and long-term functional plastic changes in the white matter and plays active roles in brain circuit functions.
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