| Project/Area Number |
23680044
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fusional basic brain science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KAZAMA Hokto 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (90546574)
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| Co-Investigator(Renkei-kenkyūsha) |
ENDO Keita 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (40425616)
SHIOZAKI Hiroshi 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (50630571)
BADEL Laurent 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (50599123)
TAKAGI Yoshiko 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (30415210)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Keywords | 記憶 / ショウジョウバエ / オペラント条件付け / イメージング / 電気生理学 / 匂い記憶 / シナプス伝達 / キノコ体 / パッチクランプ法 / 嗅覚情報処理 / カルシウムイメージング / 光遺伝学 / 古典的条件付け |
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| Research Abstract |
Memory that supports human activity is thought to be embedded in the brain as changes in cellular morphology and activity. However, the mechanisms underlying memory is not well understood. By focusing on olfactory memory in the adult Drosophila, this study aimed to understand the mechanisms of memory at cellular, synaptic, and circuit levels. We were able to develop a method to create memories in individual animals, to record the activity simultaneously from an ensemble of neurons involved in memory, and to analyze electrical properties of neurons and synapses in a brain region responsible for olfactory memory.
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