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Design of minimum ECM using cell-selective peptides for medical implant coating

Research Project

Project/Area Number 23680055
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionNagoya University

Principal Investigator

KATO Ryuji  名古屋大学, 創薬科学研究科, 准教授 (50377884)

Co-Investigator(Renkei-kenkyūsha) NARITA Yuji  名古屋大学, 医学系研究科, 講師 (60378221)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords細胞選択性 / ECM / 人工血管 / ポリカプロラクトン / エレクトロスピニング / クリックケミストリー / ペプチドマイクロアレイ / 再生促進 / ペプチド / 内皮細胞 / 平滑筋細胞 / マテリアル / スクリーニング / ECM
Research Abstract

This research was conducted to develop novel bio-material for the coating organic molecules for next generation medical implants. Especially, we focused to find the Minimum short peptide sequences to construct artificial Extracellular Matrix (ECM) to function as cell-selective performance. We succeeded to exhaustively screen the 8000 short peptide libraries for their cellular selectivity, anti-thrombosis effect, and ECM adhesive effect and found the minimum sequences and their rankings to construct artificial ECM.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (40 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (36 results) (of which Invited: 5 results)

  • [Journal Article] Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells2012

    • Author(s)
      Kanie K, Narita Y, Zhao Y, Kuwabara F, Satake M, Honda S, Kaneko H, Yoshioka T, Okochi M, Honda H, Kato R
    • Journal Title

      Biotechnology Bioengineering

      Volume: 109(7) Pages: 1808-1816

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells.2012

    • Author(s)
      Kanie K, Narita Y, Zhao Y, Kuwabara F, Satake M, Honda S, Kaneko H, Yoshioka T, Okochi M, Honda H, Kato R.
    • Journal Title

      Biotechnology Bioengineering

      Volume: 109(7) Issue: 7 Pages: 1808-1816

    • DOI

      10.1002/bit.24459

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトCollagen における細胞選択的ペプチドの分布2012

    • Author(s)
      蟹江慧, 成田裕司, 桑原史明, 佐竹真, 本多勧, 兼子博章、本多裕之、加藤竜司
    • Journal Title

      高分子論文集

      Volume: 69(3) Pages: 129-134

    • NAID

      10030170696

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Small-Caliber Vascular Grafts With Trimeric Peptide for Acceleration of Endothelialization2011

    • Author(s)
      Fumiaki Kuwabara, Yuji Narita, Aika Yamawaki-Ogata, Kei Kanie, Ryuji Kato, Makoto Satake, Hiroaki Kaneko, Hideki Oshima, Akihiko Usui, Yuichi Ueda
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 93(1) Issue: 1 Pages: 156-163

    • DOI

      10.1016/j.athoracsur.2011.07.055

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 再生促進医療機器被覆のための細胞選択的ペプチドの探索2013

    • Author(s)
      蟹江 慧 、大脇潤己、 趙瑛梓、桑原史明、成田裕司、佐竹真、兼子博章、本多裕之、加藤 竜司
    • Organizer
      化学工学会第78年会
    • Place of Presentation
      大阪大学豊中キャンパス, 大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 再生促進型医療機器のための機能性分子デザイン2012

    • Author(s)
      加藤竜司
    • Organizer
      特別講演
    • Place of Presentation
      スパイバー株式会社、鶴岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Comprehensive screening of cell-selective adhesion peptides and characteristic analysis by using clustering method2012

    • Author(s)
      Kei Kanie, Junki Owaki, Yingzi Zhao, Fumiaki Kuwabara, Makoto Satake, Susumu Honda, Hiroaki Kaneko, Yuji Narita, Hiroyuki Honda and Ryuji Kato
    • Organizer
      International Society for Stem Cell Research(ISSCR) 10th Annual Meeting
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 再生促進型医療機器表面改質のための細胞選択的ペプチドの網羅的探索2012

    • Author(s)
      蟹江慧, 大脇潤己, 成田裕司, 趙瑛梓, 桑原史明, 佐竹真, 本多裕之, 加藤竜司
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞選択性ペプチド含有エレクトロスピニングファイバーシートの有効性2012

    • Author(s)
      蟹江慧, 近藤優人, 大脇潤己, 成田裕司, 佐竹真, 本多裕之, 加藤竜司
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ECM由来細胞選択性ペプチドマテリアルの可能性2011

    • Author(s)
      加藤竜司
    • Organizer
      Smart Biomaterials Group, Bio-functional materials Unit, National Institute for Materials Science (NIMS),講演会
    • Place of Presentation
      NIMIS、つくば(招待講演)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再生促進医療機器被覆のための細胞選択的接着ペプチドの効率的探索2011

    • Author(s)
      大脇潤己、蟹江慧、加藤竜司、趙瑛梓、桑原史明、佐竹真、本多進、兼子博章、成田裕司、本多裕之
    • Organizer
      第63回生物工学会大会
    • Place of Presentation
      東京農工大学、東京
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] コラーゲンType IV選択性ペプチドの探索2011

    • Author(s)
      近藤優人、大脇潤己、蟹江慧、加藤竜司、成田裕司、本多裕之
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] クラスタリングを用いた細胞選択性ペプチドの網羅的探索と特性分析2011

    • Author(s)
      大脇潤己、蟹江慧、加藤竜司、成田裕司、本多裕之
    • Organizer
      化学工学会第43回秋李大会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Design of medical device surface for vascular tissue regeneration, International Symposium on Smart Biomaterials

    • Author(s)
      Rio Kurimoto
    • Organizer
      NIMS
    • Place of Presentation
      筑波(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] 医療機器高機能化のための表面・生体分子・細胞接着の最適化界面ツール

    • Author(s)
      蟹江慧、栗本理央、荏原充宏、井戸田直和、成田裕司、本多裕之、加藤竜司
    • Organizer
      第13回日本再生医療学会
    • Place of Presentation
      京都国際会議場、京都(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 医療機器設計を目指したペプチド修飾材料表面の物性評価と細胞接着の関係

    • Author(s)
      栗本理央、蟹江慧、荏原充宏、井戸田直和、鈴木庸元、成田裕司、本多裕之、加藤竜司
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、東京(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 医療機器被覆のための細胞選択的接着ペプチドの探索

    • Author(s)
      蟹江慧、趙瑛梓、大脇潤己、桑原史明、佐竹真、兼子博章、成田裕司、本多裕之、加藤竜司
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、東京(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨再生促進のための骨芽細胞成熟化ペプチドのスクリーニング法の開発

    • Author(s)
      蟹江慧,鈴木庸元,成田裕司,本多裕之,加藤竜司
    • Organizer
      第65回日本生物工学会大会
    • Place of Presentation
      広島国際会議場、広島(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Screening of cell-maturation peptides for enhancing bone regeneration

    • Author(s)
      Tsuneharu Suzuki, Kei Kanie, Yyuji Narita, Hiroyuki Honda and Ryuji Kato
    • Organizer
      IGER International Symposium on Cell Surface Structures and Functions
    • Place of Presentation
      名古屋大学、愛知(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Design of medical device surface for vascular tissue regeneration

    • Author(s)
      Rio Kurimoto, Kei Kanie, Mitsuhiro Ebara, Naokazu Idota, Tsuneharu Suzuki, Yuji Narita, Hiroyuki Honda and Ryuji Kato
    • Organizer
      IGER International Symposium on Cell Surface Structures and Functions
    • Place of Presentation
      名古屋大学、愛知(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Screening of cell-specific adhesion peptides for medical device coating

    • Author(s)
      Kei Kanie, Junki Owaki, Yuji Narita, Yingzi Zhao, Fumiaki Kuwabara, Makoto Satake, Susumu Honda, Hiroaki Kaneko, Hiroyuki Honda and Ryuji Kato
    • Organizer
      IGER International Symposium on Cell Surface Structures and Functions
    • Place of Presentation
      名古屋大学、愛知(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Peptide-based Interpretation of Cell-type Specific Adhesion for Tissue Engineering

    • Author(s)
      Ryuji Kato, Hiroyuki Honda
    • Organizer
      IGER International Symposium on Cell Surface Structures and Functions
    • Place of Presentation
      名古屋大学、愛知(Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨芽細胞成熟化促進ペプチドの網羅的スクリーニング法の開発

    • Author(s)
      鈴木庸元,蟹江慧,成田裕司,本多裕之,加藤竜司
    • Organizer
      2012年度日本生物工学会若手研究者の集い
    • Place of Presentation
      フェニックスシーアガイアリゾー、宮崎(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] 情報処理解析を用いた胆汁酸結合短鎖ペプチドの効率的探索と解釈

    • Author(s)
      蟹江慧,加賀千晶,森川健正,山下祐加,長岡利,本多裕之,加藤竜司
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜、神奈川(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨芽細胞成熟化促進ペプチドの網羅的スクリーニング法の開発

    • Author(s)
      蟹江慧,鈴木庸元,成田裕司,本多裕之,加藤竜司
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜、神奈川(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生促進医療機器被覆のための細胞選択的ペプチドの探索

    • Author(s)
      蟹江慧,大脇潤己,趙瑛梓,桑原史明,成田裕司,佐竹真,兼子博章,本多裕之,加藤竜司
    • Organizer
      化学工学会第78年会
    • Place of Presentation
      大阪大学豊中キャンパス、大阪(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhanced screening and understanding of hypolipidemic peptides assisted by informatics

    • Author(s)
      K. Kanie, S. Nagaoka, C. Kaga, H. Honda, R. Kato
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      TowerHall船堀,東京(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Comprehensive screening of cell-selective adhesion peptides and characteristic analysis by using clustering method

    • Author(s)
      Kei Kanie, Junki Owaki, Yingzi Zhao, Fumiaki Kuwabara, Makoto Satake, Susumu Honda, Hiroaki Kaneko, Yuji Narita, Hiroyuki Honda and Ryuji Kato
    • Organizer
      International Society for Stem Cell Research(ISSCR) 10th Annual Meeting
    • Place of Presentation
      Pacifico Yokohama, Yokohama(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生促進型医療機器表面改質のための細胞選択的ペプチドの網羅的探索

    • Author(s)
      蟹江慧,大脇潤己,成田裕司,趙瑛梓,桑原史明,佐竹真,本多裕之,加藤竜司
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜、横浜(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞選択性ペプチド含有エレクトロスピニングファイバーシートの有効性

    • Author(s)
      蟹江慧,近藤優人,大脇潤己,成田裕司,佐竹真,本多裕之,加藤竜司
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜、横浜(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Peptide coating for selective cell adhesion on the medical device

    • Author(s)
      Ryuji Kato
    • Organizer
      International Conference on Thin Films (ICTF-15)
    • Place of Presentation
      Kyoto Terresa, Kyoto(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生促進医療機器被覆のための細胞選択的接着ペプチドの効率的探索

    • Author(s)
      大脇潤己、蟹江慧、加藤竜司、趙瑛梓、桑原史明、佐竹真、本多進、兼子博章、成田裕司、本多裕之
    • Organizer
      第63回生物工学会大会
    • Place of Presentation
      東京農工大学、東京(Oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] クラスタリングを用いた細胞選択性ペプチドの網羅的探索と特性分析

    • Author(s)
      大脇潤己、蟹江慧、加藤竜司、成田裕司、本多裕之
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学、名古屋(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] コラーゲンType IV選択性ペプチドの探索

    • Author(s)
      近藤優人、大脇潤己、蟹江慧、加藤竜司、成田裕司、本多裕之
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学、名古屋(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生促進医療機器被覆のための細胞選択性ペプチド探索

    • Author(s)
      大脇潤己、蟹江慧、加藤竜司、成田裕司、大河内美奈、本多裕之
    • Organizer
      生物工学若手研究者の集い夏のセミナー2011
    • Place of Presentation
      春日井びゅーほてる、山梨(Poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] Design of medical device surface for vascular tissue regeneration

    • Author(s)
      栗本理央
    • Organizer
      International Symposium on Smart Biomaterials
    • Place of Presentation
      NIMS、筑波
    • Related Report
      2013 Annual Research Report
  • [Presentation] 医療機器設計を目指したペプチド修飾材料表面の物性評価と細胞接着の関係

    • Author(s)
      栗本理央、蟹江慧、荏原充宏、井戸田直和、鈴木庸元、成田裕司、本多裕之、加藤竜司
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 医療機器被覆のための細胞選択的接着ペプチドの探索

    • Author(s)
      蟹江慧、趙瑛梓、大脇潤己、桑原史明、佐竹真、兼子博章、成田裕司、本多裕之、加藤竜司
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Design of medical device surface for vascular tissue regeneration

    • Author(s)
      Rio Kurimoto, Kei Kanie, Mitsuhiro Ebara, Naokazu Idota, Tsuneharu Suzuki, Yuji Narita, Hiroyuki Honda and Ryuji Kato
    • Organizer
      IGER International Symposium on Cell Surface Structures and Functions
    • Place of Presentation
      名古屋大学、愛知
    • Related Report
      2013 Annual Research Report
  • [Presentation] Screening of cell-specific adhesion peptides for medical device coat

    • Author(s)
      Kei Kanie, Junki Owaki, Yuji Narita, Yingzi Zhao, Fumiaki Kuwabara, Makoto Satake, Susumu Honda, Hiroaki Kaneko, Hiroyuki Honda and Ryuji Kato
    • Organizer
      IGER International Symposium on Cell Surface Structures and Functions
    • Place of Presentation
      名古屋大学、愛知
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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