Design of minimum ECM using cell-selective peptides for medical implant coating
| Project/Area Number |
23680055
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya University |
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Principal Investigator |
KATO Ryuji 名古屋大学, 創薬科学研究科, 准教授 (50377884)
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| Co-Investigator(Renkei-kenkyūsha) |
NARITA Yuji 名古屋大学, 医学系研究科, 講師 (60378221)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 細胞選択性 / ECM / 人工血管 / ポリカプロラクトン / エレクトロスピニング / クリックケミストリー / ペプチドマイクロアレイ / 再生促進 / ペプチド / 内皮細胞 / 平滑筋細胞 / マテリアル / スクリーニング / ＥＣＭ |
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| Research Abstract |
This research was conducted to develop novel bio-material for the coating organic molecules for next generation medical implants. Especially, we focused to find the Minimum short peptide sequences to construct artificial Extracellular Matrix (ECM) to function as cell-selective performance. We succeeded to exhaustively screen the 8000 short peptide libraries for their cellular selectivity, anti-thrombosis effect, and ECM adhesive effect and found the minimum sequences and their rankings to construct artificial ECM.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells2012
Author(s)
Kanie K, Narita Y, Zhao Y, Kuwabara F, Satake M, Honda S, Kaneko H, Yoshioka T, Okochi M, Honda H, Kato R
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Journal Title
Biotechnology Bioengineering
Volume: 109(7)
Pages: 1808-1816
Related Report
Peer Reviewed
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[Journal Article] Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells.2012
Author(s)
Kanie K, Narita Y, Zhao Y, Kuwabara F, Satake M, Honda S, Kaneko H, Yoshioka T, Okochi M, Honda H, Kato R.
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Journal Title
Biotechnology Bioengineering
Volume: 109(7)
Issue: 7
Pages: 1808-1816
DOI
Related Report
Peer Reviewed
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[Presentation] ECM由来細胞選択性ペプチドマテリアルの可能性2011
Author(s)
加藤竜司
Organizer
Smart Biomaterials Group, Bio-functional materials Unit, National Institute for Materials Science (NIMS),講演会
Place of Presentation
NIMIS、つくば(招待講演)
Year and Date
2011-11-29
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