Neurorehabilitation via neural interface
| Project/Area Number |
23680061
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
NISHIMURA Yukio 生理学研究所, 発達生理学研究系, 准教授 (20390693)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 人工神経接続 / リハビリテーション / 脊髄損傷 / BCI / 脊髄 / 磁気刺激 / Brain computer interface / 随意歩行 / 手 / 随意運動 / Brain-computer interface / 脳梗塞 / 歩行再建 |
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| Outline of Final Research Achievements |
Functional loss of limb control in individuals with neural damage is attributed to interruption of descending pathways to spinal network. Although neural circuits locate below and above the lesion remain functional. We investigated that an artificial neuronal connection that bridges supra-spinal system and spinal network beyond the lesion site restores lost function. A promising application was to bridge impaired spinal cord lesion, as demonstrated that volitionally controlled walking in individuals with spinal cord lesion can be restored by muscle-controlled stimulation to lumbar spinal cord. Furthermore, we investigated the motor adaptation process to a novel artificial recurrent connection from a muscle to a peripheral nerve. We found that participants could control muscle activity to utilize a novel connection into the volitional control of upper limb. Thus these protocols developed as promising neuroprosthesis for individuals who have residual neural systems after neural damage.
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Report
(5 results)
Research Products
(64 results)
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[Journal Article] Differential Expression of Secreted Phosphoprotein l in the Motor Cortex among Primate Species and during Postnatal Development and Functional Recovery2013
Author(s)
T. Yamamoto, T. Oishi, N. Higo, S. Murayama, A. Sato, I. Takashima, Y. Sugiyama, Y. Nishimura, Y. Murata, K. Yoshino-Saito, T. Isa, T. Kojima
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Journal Title
PLOS ONE
Volume: 8(5)
Issue: 5
Pages: 1-13
DOI
Related Report
Peer Reviewed
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